2016
Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition
Starc M, Murray JD, Santamauro N, Savic A, Diehl C, Cho YT, Srihari V, Morgan PT, Krystal JH, Wang XJ, Repovs G, Anticevic A. Schizophrenia is associated with a pattern of spatial working memory deficits consistent with cortical disinhibition. Schizophrenia Research 2016, 181: 107-116. PMID: 27745755, PMCID: PMC5901719, DOI: 10.1016/j.schres.2016.10.011.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsSpatial WM taskSchizophrenia patientsSevere cognitive deficitsSpecific spatial locationsComputational modelContinuous response measuresWM precisionWM representationsSpatial WMWM taskDistractor distanceWM impairmentWM tracesNeural mechanismsCognitive deficitsMemory deficitsBehavioral consequencesDelay periodDelay durationCortical disinhibitionSpatial locationComparison subjectsMicrocircuit modelDistractibility
2013
Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals
Matuskey D, Luo X, Zhang S, Morgan PT, Abdelghany O, Malison RT, Li CS. Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals. Psychiatry Research 2013, 214: 116-121. PMID: 23973363, PMCID: PMC3811038, DOI: 10.1016/j.pscychresns.2013.06.009.Peer-Reviewed Original ResearchMeSH KeywordsAdultCentral Nervous System StimulantsCerebral CortexCocaine-Related DisordersCognition DisordersFemaleHumansImage Processing, Computer-AssistedInhibition, PsychologicalMagnetic Resonance ImagingMaleMethylphenidateMiddle AgedModels, NeurologicalNeural PathwaysNeuropsychological TestsOxygenPhotic StimulationReaction TimeConceptsFunctional magnetic resonance imagingStop-signal taskCD individualsCerebral activationPrecuneus/posterior cingulate cortexSystolic blood pressureInfluence of methylphenidateEffects of methylphenidateMagnetic resonance imagingPosterior cingulate cortexBrain imaging studiesCocaine-addicted individualsDefault mode networkAgonist therapyBlood pressureIntravenous methylphenidateCortico-striatoHealthy controlsCocaine-dependent individualsThalamic activationCingulate cortexResonance imagingBrain regionsMethylphenidateCocaine dependenceThe Impact of NMDA Receptor Blockade on Human Working Memory-Related Prefrontal Function and Connectivity
Driesen NR, McCarthy G, Bhagwagar Z, Bloch MH, Calhoun VD, D'Souza DC, Gueorguieva R, He G, Leung HC, Ramani R, Anticevic A, Suckow RF, Morgan PT, Krystal JH. The Impact of NMDA Receptor Blockade on Human Working Memory-Related Prefrontal Function and Connectivity. Neuropsychopharmacology 2013, 38: 2613-2622. PMID: 23856634, PMCID: PMC3828532, DOI: 10.1038/npp.2013.170.Peer-Reviewed Original ResearchConceptsNMDA-Rs
2010
Lucid dreaming and ventromedial versus dorsolateral prefrontal task performance
Neider M, Pace-Schott EF, Forselius E, Pittman B, Morgan PT. Lucid dreaming and ventromedial versus dorsolateral prefrontal task performance. Consciousness And Cognition 2010, 20: 234-244. PMID: 20829072, PMCID: PMC3026881, DOI: 10.1016/j.concog.2010.08.001.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAwarenessDreamsFemaleGamblingHumansMaleNeuropsychological TestsPrefrontal CortexSleepTask Performance and Analysis
2008
Cocaine Users Differ from Normals on Cognitive Tasks Which Show Poorer Performance During Drug Abstinence
Pace-Schott EF, Morgan PT, Malison RT, Hart CL, Edgar C, Walker M, Stickgold R. Cocaine Users Differ from Normals on Cognitive Tasks Which Show Poorer Performance During Drug Abstinence. The American Journal Of Drug And Alcohol Abuse 2008, 34: 109-121. PMID: 18161649, DOI: 10.1080/00952990701764821.Peer-Reviewed Original ResearchConceptsVerbal recognition memoryCocaine usersCocaine-dependent individualsCocaine-induced impairmentRecognition memoryCognitive tasksCognitive batteryCognitive changesDrug-free baselineDrug abstinenceAbstinencePoor performanceMemoryCocaine useDrug useDay cocaineNormative valuesAttentionCocaineTaskImpairmentIndividualsBatteriesInpatient study