A Bcl-xL–Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis
Li H, Alavian KN, Lazrove E, Mehta N, Jones A, Zhang P, Licznerski P, Graham M, Uo T, Guo J, Rahner C, Duman RS, Morrison RS, Jonas EA. A Bcl-xL–Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Nature Cell Biology 2013, 15: 773-785. PMID: 23792689, PMCID: PMC3725990, DOI: 10.1038/ncb2791.Peer-Reviewed Original ResearchConceptsBcl-xLVesicle retrievalProtein-protein interactionsClathrin-coated pitsProtein Bcl-xLCalmodulin-dependent mannerRecruitment of vesiclesNeurotransmitter releaseDepletion of Drp1GTPase Drp1Vesicle endocytosisEndocytic vesiclesMembrane dynamicsPlasma membraneClathrin complexMutagenesis studiesPresynaptic plasticityMitochondrial ATPATP availabilityReserve poolDrp1EndocytosisVesiclesHippocampal neuronsComplexesIncomplete and Inaccurate Vocal Imitation after Knockdown of FoxP2 in Songbird Basal Ganglia Nucleus Area X
Haesler S, Rochefort C, Georgi B, Licznerski P, Osten P, Scharff C. Incomplete and Inaccurate Vocal Imitation after Knockdown of FoxP2 in Songbird Basal Ganglia Nucleus Area X. PLOS Biology 2007, 5: e321. PMID: 18052609, PMCID: PMC2100148, DOI: 10.1371/journal.pbio.0050321.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBasal GangliaFinchesForkhead Transcription FactorsLentivirusMaleMolecular Sequence DataRNA InterferenceVocalization, AnimalConceptsDevelopmental verbal dyspraxiaVocal imitationKnockdown of FoxP2Comprehension of grammarVocal motor learningSong learningWord productionMutations of FOXP2Neural parallelsLanguage disordersHuman speechHuman languageMotor learningFluent productionVerbal dyspraxiaSong ontogenyTutor songSpeechImitationBasal ganglia structuresAcoustic structureLearningGanglia structuresBasal gangliaFoxP2 levels