A Bcl-xL–Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis
Li H, Alavian KN, Lazrove E, Mehta N, Jones A, Zhang P, Licznerski P, Graham M, Uo T, Guo J, Rahner C, Duman RS, Morrison RS, Jonas EA. A Bcl-xL–Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Nature Cell Biology 2013, 15: 773-785. PMID: 23792689, PMCID: PMC3725990, DOI: 10.1038/ncb2791.Peer-Reviewed Original ResearchConceptsBcl-xLVesicle retrievalProtein-protein interactionsClathrin-coated pitsProtein Bcl-xLCalmodulin-dependent mannerRecruitment of vesiclesNeurotransmitter releaseDepletion of Drp1GTPase Drp1Vesicle endocytosisEndocytic vesiclesMembrane dynamicsPlasma membraneClathrin complexMutagenesis studiesPresynaptic plasticityMitochondrial ATPATP availabilityReserve poolDrp1EndocytosisVesiclesHippocampal neuronsComplexesDecreased expression of synapse-related genes and loss of synapses in major depressive disorder
Kang HJ, Voleti B, Hajszan T, Rajkowska G, Stockmeier CA, Licznerski P, Lepack A, Majik MS, Jeong LS, Banasr M, Son H, Duman RS. Decreased expression of synapse-related genes and loss of synapses in major depressive disorder. Nature Medicine 2012, 18: 1413-1417. PMID: 22885997, PMCID: PMC3491115, DOI: 10.1038/nm.2886.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsCalmodulinCell LineDepressive Disorder, MajorGATA1 Transcription FactorGene Expression ProfilingGene Expression RegulationHumansMicroarray AnalysisMicroscopy, ElectronPrefrontal CortexRab3A GTP-Binding ProteinRab4 GTP-Binding ProteinsRatsReverse Transcriptase Polymerase Chain ReactionSynapsesSynapsinsTubulin