2014
Primary Care–Based Buprenorphine Taper vs Maintenance Therapy for Prescription Opioid Dependence: A Randomized Clinical Trial
Fiellin DA, Schottenfeld RS, Cutter CJ, Moore BA, Barry DT, O’Connor P. Primary Care–Based Buprenorphine Taper vs Maintenance Therapy for Prescription Opioid Dependence: A Randomized Clinical Trial. JAMA Internal Medicine 2014, 174: 1947-1954. PMID: 25330017, PMCID: PMC6167926, DOI: 10.1001/jamainternmed.2014.5302.Peer-Reviewed Original ResearchConceptsPrescription opioid dependenceOngoing maintenance therapyIllicit opioid useMaintenance therapyOpioid dependenceBuprenorphine taperBuprenorphine therapyTaper groupMaintenance groupOpioid usePrimary careClinical trialsPrimary care-based treatmentSignificant public health burdenBuprenorphine maintenance therapyOngoing maintenance treatmentPrimary care physiciansEvidence-based guidelinesPrimary care sitesPublic health burdenWeeks of stabilizationHydrochloride therapyOpioid withdrawalBuprenorphine treatmentNaltrexone treatment
2006
Counseling plus Buprenorphine–Naloxone Maintenance Therapy for Opioid Dependence
Fiellin DA, Pantalon MV, Chawarski MC, Moore BA, Sullivan LE, O'Connor PG, Schottenfeld RS. Counseling plus Buprenorphine–Naloxone Maintenance Therapy for Opioid Dependence. New England Journal Of Medicine 2006, 355: 365-374. PMID: 16870915, DOI: 10.1056/nejmoa055255.Peer-Reviewed Original ResearchConceptsStandard medical managementBuprenorphine-naloxone treatmentIllicit opioid useMedical managementOpioid dependenceWeekly medicationOpioid useIllicit opioidsWeekly counselingPrimary careUrine specimensConsecutive weeksProportion of patientsImproved treatment outcomesMaintenance therapyPrimary outcomeClinical trialsMedication distributionSimilar efficacyTreatment outcomesMedicationsSelf-reported frequencyPatientsFrequency of attendanceMean percentage
2002
A Staging System to Predict Prognosis among Methadone Maintenance Patients, Based on Admission Characteristics
Favrat B, Rao S, O'Connor PG, Schottenfeld R. A Staging System to Predict Prognosis among Methadone Maintenance Patients, Based on Admission Characteristics. Substance Use & Addiction Journal 2002, 23: 233-244. PMID: 12438836, DOI: 10.1080/08897070209511496.Peer-Reviewed Original ResearchConceptsStaging systemAdverse dischargeOpioid maintenance therapyU.S. general internistsMethadone maintenance patientsMethadone maintenance treatmentMain outcome measuresMethadone maintenance programProportional hazards modelIllicit drug useHistory of diseaseOutset of treatmentPrevious prison termsMaintenance therapyConsecutive patientsEntire cohortMaintenance patientsMaintenance treatmentAdmission characteristicsOutcome measuresGeneral internistsPrognostic studiesStage IIIPatientsStage IA Staging System to Predict Prognosis Among Methadone Maintenance Patients, Based on Admission Characteristics
Favrat B, Rao S, O'Connor P, Schottenfeld R. A Staging System to Predict Prognosis Among Methadone Maintenance Patients, Based on Admission Characteristics. Substance Use & Addiction Journal 2002, 23: 233-244. DOI: 10.1023/a:1021150217215.Peer-Reviewed Original ResearchStaging systemAdverse dischargeOpioid maintenance therapyU.S. general internistsMethadone maintenance patientsMethadone maintenance treatmentMain outcome measuresMethadone maintenance programProportional hazards modelIllicit drug useHistory of diseaseOutset of treatmentPrevious prison termsMaintenance therapyConsecutive patientsEntire cohortMaintenance patientsMaintenance treatmentAdmission characteristicsOutcome measuresGeneral internistsPrognostic studiesStage IIIPatientsStage I
2001
Methadone Maintenance in Primary Care: A Randomized Controlled Trial
Fiellin DA, O'Connor PG, Chawarski M, Pakes JP, Pantalon MV, Schottenfeld RS. Methadone Maintenance in Primary Care: A Randomized Controlled Trial. JAMA 2001, 286: 1724-1731. PMID: 11594897, DOI: 10.1001/jama.286.14.1724.Peer-Reviewed Original ResearchConceptsOpioid-dependent patientsNarcotic treatment programsOffice-based careStable opioid-dependent patientsIllicit drug usePrimary care physiciansMethadone maintenanceUse of healthDrug useNTP patientsCare physiciansClinical instabilityFunctional statusPrimary care physician's officeMethadone maintenance therapyPrimary care internistsMethadone maintenance patientsOpen clinical trialIllicit opiate useToxicology test resultsQuality of careMaintenance therapyUsual careControlled TrialsOpioid dependence