2006
Alterations in Expression and Chromatin Configuration of the Alpha Hemoglobin-Stabilizing Protein Gene in Erythroid Krüppel-Like Factor-Deficient Mice
Pilon AM, Nilson DG, Zhou D, Sangerman J, Townes TM, Bodine DM, Gallagher PG. Alterations in Expression and Chromatin Configuration of the Alpha Hemoglobin-Stabilizing Protein Gene in Erythroid Krüppel-Like Factor-Deficient Mice. Molecular And Cellular Biology 2006, 26: 4368-4377. PMID: 16705186, PMCID: PMC1489081, DOI: 10.1128/mcb.02216-05.Peer-Reviewed Original ResearchConceptsErythroid Krüppel-like factorAlpha-hemoglobin-stabilizing proteinWild-type chromatinAHSP promoterCACCC siteBeta-globin gene transcriptionDNase I hypersensitive sitesLocal chromatin structureZinc finger proteinBeta-globin promoterKrüppel-like factorMobility shift assaysBeta-globin geneErythroid genesCACCC sequenceChromatin modulatorsFinger proteinChromatin structureSubtractive hybridizationChromatin statusCACCC boxTranscription factorsProtein geneChromatin configurationHypersensitive sites
2005
The Human Alpha Hemoglobin Stabilizing Protein (AHSP) Gene Locus in EKLF-Deficient Erythroid Cells.
Pilon A, Zhou D, Weiss M, Townes T, Bodine D, Gallagher P. The Human Alpha Hemoglobin Stabilizing Protein (AHSP) Gene Locus in EKLF-Deficient Erythroid Cells. Blood 2005, 106: 1740. DOI: 10.1182/blood.v106.11.1740.1740.Peer-Reviewed Original ResearchCACCC siteErythroid cellsWild typeModifier genesDNase I hypersensitive site mappingLocal chromatin structureΒ-globin transcriptionErythroid-specific proteinΒ-globin gene promoterDNA-protein complexesFetal liver cellsTranscription factor EKLFChromatin immunoprecipitation analysisΒ-globin sequencesHypersensitive site mappingFetal liverMobility shift assaysPromoter-luciferase reporter plasmidProximal CACCC boxFetal liver DNACore promoter regionAHSP promoterDeficient fetal liver cellsEKLF geneChromatin modulators