2019
Development of an Antibiotic Guideline for Children With Suspected Ventilator-Associated Infections.
Shein SL, Karam O, Beardsley A, Karsies T, Prentice E, Tarquinio KM, Willson DF. Development of an Antibiotic Guideline for Children With Suspected Ventilator-Associated Infections. Pediatric Critical Care Medicine 2019, 20: 697-706. PMID: 30985606, DOI: 10.1097/pcc.0000000000001942.Peer-Reviewed Original ResearchConceptsVentilator-associated infectionPhase 1 dataAntibiotic guidelinesGuideline scoreAntibiotic usePediatric Logistic Organ Dysfunction-2 scoreDuration of antibioticsPICU-free daysVentilator-Associated InfectionsVentilator-free daysInitiation of antibioticsProspective data collectionPhase 3Median ageMechanical ventilationVentilated childrenScore 3Consensus conferenceClinical testingScoring systemInfectionLiterature searchExpert panelAntibioticsScores
2017
Rapid detection and ruling out of neonatal sepsis by PCR coupled with Electrospray Ionization Mass Spectrometry (PCR/ESI-MS)
Delcò C, Karam O, Pfister R, Gervaix A, Renzi G, Emonet S, Schrenzel J, Posfay-Barbe KM. Rapid detection and ruling out of neonatal sepsis by PCR coupled with Electrospray Ionization Mass Spectrometry (PCR/ESI-MS). Early Human Development 2017, 108: 17-22. PMID: 28343091, DOI: 10.1016/j.earlhumdev.2017.03.004.Peer-Reviewed Original ResearchConceptsNegative predictive valuePCR/ESI-MSBlood culturesPredictive valueNeonatal sepsisGood negative predictive valueProspective observational studyBlood culture resultsInitiation of antibioticsPositive blood culturesConventional blood culturePositive predictive valueEmpiric antibioticsConsecutive neonatesAdverse eventsClinical suspicionMedian ageNeonatal populationObservational studySepsisBlood samplesEarly reassessmentImportant causeCulture resultsBacterial infections