2003
Effects of nicotine deprivation on urges to drink and smoke in alcoholic smokers
Cooney JL, Cooney NL, Pilkey DT, Kranzler HR, Oncken CA. Effects of nicotine deprivation on urges to drink and smoke in alcoholic smokers. Addiction 2003, 98: 913-921. PMID: 12814497, DOI: 10.1046/j.1360-0443.2003.00337.x.Peer-Reviewed Original ResearchConceptsNicotine deprivationSmoking urgesSelf-reported urgeAcute nicotine deprivationNon-deprived stateDay treatment programAlcohol-dependent smokersNeutral cuesMood inductionCue presentationCue exposureSubjects designTreatment programLaboratory sessionsUrgeRisk of relapseSessionsAlcoholic smokersSmoking cessationHeavy smokersAlcoholic patientsAcute effectsEarly recoverySmokersCues
2001
Effect of Tryptophan Depletion on Alcohol Cue‐Induced Craving in Abstinent Alcoholic Patients
Petrakis I, Trevisan L, Boutros N, Limoncelli D, Cooney N, Krystal J. Effect of Tryptophan Depletion on Alcohol Cue‐Induced Craving in Abstinent Alcoholic Patients. Alcohol Clinical And Experimental Research 2001, 25: 1151-1155. PMID: 11505046, DOI: 10.1111/j.1530-0277.2001.tb02329.x.Peer-Reviewed Original ResearchConceptsCue-induced cravingAlcohol-dependent patientsTryptophan depletionAlcohol cue-induced cravingDouble-blind fashionPlasma free tryptophanAbstinent alcoholic patientsAmino acid drinkActive tryptophan depletionAlcoholic patientsSerotonin synthesisAcid drinkSober alcoholicsAlcoholic individualsPrecursor tryptophanCue exposurePatientsAlcohol useAbstinent alcoholic individualsCravingFree tryptophanAlcohol cuesTest dayGreater increaseSimilar drinks
1997
Evidence of acoustic startle hyperreflexia in recently detoxified early onset male alcoholics: modulation by yohimbine and m-Chlorophenylpiperazine (mCPP)
Krystal J, Webb E, Grillon C, Cooney N, Casal L, Morgan III. C, Southwick S, Davis M, Charney D. Evidence of acoustic startle hyperreflexia in recently detoxified early onset male alcoholics: modulation by yohimbine and m-Chlorophenylpiperazine (mCPP). Psychopharmacology 1997, 131: 207-215. PMID: 9203230, DOI: 10.1007/s002130050285.Peer-Reviewed Original ResearchConceptsHealthy subjectsAcoustic startle responseEthanol withdrawalStartle responseStartle magnitudeStartle amplitudeRandomized orderAcoustic startle magnitudeChronic alcoholic patientsSerotonin partial agonistDouble-blind conditionsAcoustic startle amplitudeNumber of episodesMale healthy subjectsΑ2-adrenergic antagonistTest dayMale patientsPlacebo dayAlcoholic patientsIntravenous infusionNoradrenergic functionYohimbine effectAlcohol detoxificationDrug infusionPreclinical studies
1996
Serotonergic and noradrenergic dysregulation in alcoholism: m- chlorophenylpiperazine and yohimbine effects in recently detoxified alcoholics and healthy comparison subjects
Krystal JH, Webb E, Cooney NL, Kranzler HR, Southwick SW, Heninger GR, Charney DS. Serotonergic and noradrenergic dysregulation in alcoholism: m- chlorophenylpiperazine and yohimbine effects in recently detoxified alcoholics and healthy comparison subjects. American Journal Of Psychiatry 1996, 153: 83-92. PMID: 8540598, DOI: 10.1176/ajp.153.1.83.Peer-Reviewed Original ResearchConceptsHealthy comparison subjectsAlcoholic patientsComparison subjectsCortisol responseYohimbine infusionPostsynaptic noradrenergic receptorsBlood pressure responseDouble-blind conditionsNoradrenergic reactivitySaline placeboNoradrenergic receptorsMHPG levelsIntravenous infusionYohimbine effectMHPG responsePlasma levelsNoradrenergic systemPersistent alterationsNoradrenergic dysregulationMale inpatientsDrug effectsNeuroendocrine responsivityPatientsPhysiologic responsesPlasma cortisol
1990
Reactivity to alcohol cues and induced moods in alcoholics
Litt M, Cooney N, Kadden R, Gaupp L. Reactivity to alcohol cues and induced moods in alcoholics. Addictive Behaviors 1990, 15: 137-146. PMID: 2343787, DOI: 10.1016/0306-4603(90)90017-r.Peer-Reviewed Original ResearchConceptsNegative mood statesMood statesAlcohol cuesAlcohol-related stimuliNeutral mood stateNeutral moodNeutral stimuliNegative moodExteroceptive cuesInteroceptive cuesSubjects designCuesSubjects' reportsMoodConditioning processStimuliAlcoholism treatmentAlcoholic patientsAlcoholic subjectsSeparate daysDesireAlcoholic drinksAlcoholic beveragesSubjectsSmell
1986
A Validation Study of Four Scales Measuring Severity of Alcohol Dependence
COONEY N, MEYER R, KAPLAN R, BAKER L. A Validation Study of Four Scales Measuring Severity of Alcohol Dependence. Addiction 1986, 81: 223-229. PMID: 3458490, DOI: 10.1111/j.1360-0443.1986.tb00320.x.Peer-Reviewed Original ResearchConceptsDependence ScaleAlcohol consumptionDependence QuestionnaireDependence scoresInpatient alcohol rehabilitation programAlcohol rehabilitation programAlcohol Dependence QuestionnairePost-treatment abstinenceDetoxification medicationAlcoholic patientsWithdrawal ScaleRehabilitation programAlcohol dependenceSignificant positive correlationHigh convergent validityHeavy drinkingConstruct of dependenceImpaired controlDependence severityLast monthSeverityPatientsConvergent validityPsychological problemsScores