2009
Depletion of CD4+CD25+ T cells exacerbates experimental autoimmune encephalomyelitis induced by mouse, but not rat, antigens
Akirav EM, Bergman CM, Hill M, Ruddle NH. Depletion of CD4+CD25+ T cells exacerbates experimental autoimmune encephalomyelitis induced by mouse, but not rat, antigens. Journal Of Neuroscience Research 2009, 87: 3511-3519. PMID: 19125411, PMCID: PMC4429897, DOI: 10.1002/jnr.21981.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigensAutoantigensAutoimmunityBiomarkersCD4 AntigensCD4-Positive T-LymphocytesCells, CulturedCentral Nervous SystemChemotaxis, LeukocyteDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalFemaleInterferon-gammaInterleukin-10Interleukin-17Interleukin-2 Receptor alpha SubunitLymphocyte ActivationMiceMice, Inbred C57BLMultiple SclerosisMyelin ProteinsMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinRatsT-Lymphocytes, RegulatoryConceptsExperimental autoimmune encephalomyelitisMyelin oligodendrocyte glycoproteinAutoimmune encephalomyelitisT cellsIL-10-producing cellsRegulatory T cellsTissue-restricted antigensCentral nervous systemField of autoimmunityT cell activationTreg depletionEAE severitySelf antigensOligodendrocyte glycoproteinForeign antigensExperimental diseaseNervous systemRelated antigensMiceSelf-antigen specificityAntigenTregsEncephalomyelitisAutoimmunityRats
1986
Isolation of antigen-binding membrane molecules from an antigen-specific T-cell hybrid
Cone R, Beaman K, Ruddle N. Isolation of antigen-binding membrane molecules from an antigen-specific T-cell hybrid. Cellular Immunology 1986, 99: 257-264. PMID: 3489563, DOI: 10.1016/0008-8749(86)90233-9.Peer-Reviewed Original Research
1981
T Cell Tumors, Clones, and Hybrids
Ruddle N. T Cell Tumors, Clones, and Hybrids. Chemical Immunology And Allergy 1981, 29: 222-268. PMID: 7036181, DOI: 10.1159/000400099.Peer-Reviewed Original Research
1980
Regulation of self-recognition by T-cell hybrids
Ruddle N, Beezley B, Eardley D. Regulation of self-recognition by T-cell hybrids. Cellular Immunology 1980, 55: 42-55. PMID: 6968629, DOI: 10.1016/0008-8749(80)90135-5.Peer-Reviewed Original Research
1971
Experimental autoallergic encephalomyelitis and cellular hypersensitivity in vitro.
Ellison G, Waksman B, Ruddle N. Experimental autoallergic encephalomyelitis and cellular hypersensitivity in vitro. Neurology 1971, 21: 778-82. PMID: 5106293, DOI: 10.1212/wnl.21.8.778.Peer-Reviewed Original Research
1968
CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY
Ruddle N, Waksman B. CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY. Journal Of Experimental Medicine 1968, 128: 1237-1254. PMID: 4176937, PMCID: PMC2138572, DOI: 10.1084/jem.128.6.1237.Peer-Reviewed Original ResearchConceptsLymph node cellsTarget cell ratiosDelayed hypersensitivityNode cellsSoluble antigenSpecific antigenBovine gammaglobulinProgressive destructionCell ratioAntigen concentrationTarget cellsLymphocytesAntigenHypersensitivityCell enumerationEgg albuminCellsHrRat embryo fibroblastsTissue cultureLymphGammaglobulinRatsEmbryo fibroblastsCYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY
Ruddle N, Waksman B. CYTOTOXICITY MEDIATED BY SOLUBLE ANTIGEN AND LYMPHOCYTES IN DELAYED HYPERSENSITIVITY. Journal Of Experimental Medicine 1968, 128: 1255-1265. PMID: 4235040, PMCID: PMC2138586, DOI: 10.1084/jem.128.6.1255.Peer-Reviewed Original ResearchConceptsLymph node cellsNode cellsSensitized lymph node cellsArthus reactivityLewis ratsBN ratsSkin reactivityAllogeneic fibroblastsDelayed hypersensitivitySoluble antigenSpecific antigenHomologous conjugateCytotoxic effectsRatsAntigenHypersensitivityProtein carrierHuman serum albuminCellsAnimalsRat embryo fibroblastsSpecific damageSerum albuminFibroblastsConjugates
1967
Cytotoxic Effect of Lymphocyte-Antigen Interaction in Delayed Hypersensitivity
Ruddle N, Waksman B. Cytotoxic Effect of Lymphocyte-Antigen Interaction in Delayed Hypersensitivity. Science 1967, 157: 1060-1062. PMID: 6036235, DOI: 10.1126/science.157.3792.1060.Peer-Reviewed Original Research