2001
Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches
Spahn T, Fontana A, Faria A, Slavin A, Eugster H, Zhang X, Koni P, Ruddle N, Flavell R, Rennert P, Weiner H. Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches. European Journal Of Immunology 2001, 31: 1278-1287. PMID: 11298355, DOI: 10.1002/1521-4141(200104)31:4<1278::aid-immu1278>3.0.co;2-a.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAnimalsAntibodiesDose-Response Relationship, ImmunologicEnzyme-Linked Immunosorbent AssayFecesGene DeletionHypersensitivity, DelayedImmune ToleranceImmunity, MucosalImmunoglobulin AInterferon-gammaInterleukin-2Lymph NodesLymphotoxin-alphaMiceMice, Inbred BALB CMice, Inbred C57BLMice, KnockoutOvalbuminPeyer's PatchesSignal TransductionTumor Necrosis Factor-alphaConceptsGut-associated lymphoid tissueMesenteric lymph nodesOral toleranceLow-dose oral toleranceDelayed-type hypersensitivity responseFecal IgA productionLTbeta-/- miceOral tolerance inductionLamina propria lymphocytesIntact immune systemCellular immune responsesPeripheral lymphoid organsIFN-gamma productionTumor necrosis factor familyProcessing of antigensNecrosis factor familySystemic hyporesponsivenessLymph nodesHypersensitivity responseTolerance inductionIgA productionIntraperitoneal administrationLymphoid organsLymphoid tissuePeyer's patches
1996
The Contribution of Insulitis to Diabetes Development in Tumor Necrosis Factor Transgenic Mice
Flavell RA, Kratz A, Ruddle NH. The Contribution of Insulitis to Diabetes Development in Tumor Necrosis Factor Transgenic Mice. Current Topics In Microbiology And Immunology 1996, 206: 33-50. PMID: 8608724, DOI: 10.1007/978-3-642-85208-4_3.Peer-Reviewed Original ResearchConceptsInsulin-dependent diabetes mellitusTumor necrosis factor-transgenic (TNF-Tg) miceDevelopment of diabetesHLA susceptibility allelesIslets of LangerhansHLA-DQβDiabetes mellitusFrank diabetesTransgenic miceStrong associationSusceptibility allelesDiabetesIdentical twinsDiseaseInsulinIsletsInsulitisSite of synthesisMellitusNumber of yearsPatientsMiceEnvironmental factors
1987
Suppressor cells induced by total lymphoid irradiation affect proliferation and lymphokine production of murine T helper cell clones
Mate T, Ruddle N. Suppressor cells induced by total lymphoid irradiation affect proliferation and lymphokine production of murine T helper cell clones. International Journal Of Radiation Oncology • Biology • Physics 1987, 13: 61-68. PMID: 2948938, DOI: 10.1016/0360-3016(87)90261-6.Peer-Reviewed Original ResearchConceptsTotal lymphoid irradiationT helper cell clonesSuppressor cellsInterleukin-2Lymphoid irradiationT-helper cell proliferative responsesCell clonesT cell capacityT cell growth factorHelper T cellsT cell populationsCell proliferative responsesMarked inhibitory effectGamma-IFN releaseLympho-reticular tissuesCell growth factorMurine T helper cell clonesNodal irradiationType hypersensitivityAntigen responseImmune suppressionImmunosuppressive effectsLymphokine responsesAntigen presentationT cells
1982
A critical analysis of the T cell hybrid technique
Beezley B, Ruddle N. A critical analysis of the T cell hybrid technique. Journal Of Immunological Methods 1982, 52: 269-281. PMID: 6752275, DOI: 10.1016/0022-1759(82)90001-1.Peer-Reviewed Original Research