2010
Focal experimental autoimmune encephalomyelitis in the lewis rat induced by immunization with myelin oligodendrocyte glycoprotein and intraspinal injection of vascular endothelial growth factor
Sasaki M, Lankford KL, Brown RJ, Ruddle NH, Kocsis JD. Focal experimental autoimmune encephalomyelitis in the lewis rat induced by immunization with myelin oligodendrocyte glycoprotein and intraspinal injection of vascular endothelial growth factor. Glia 2010, 58: 1523-1531. PMID: 20645414, DOI: 10.1002/glia.21026.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAntibodiesBlood-Brain BarrierCD3 ComplexDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalEnzyme-Linked Immunosorbent AssayFemaleFreund's AdjuvantInjections, SpinalLipidsMicroscopy, Electron, TransmissionMyelin ProteinsMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinRatsRats, Inbred LewSpinal CordTime FactorsVascular Endothelial Growth Factor AConceptsMyelin oligodendrocyte glycoproteinVascular endothelial growth factorExperimental autoimmune encephalomyelitisIncomplete Freund's adjuvantBlood-brain barrierInflammatory demyelinating lesionsLewis ratsEndothelial growth factorDemyelinating lesionsEAE modelAutoimmune encephalomyelitisFreund's adjuvantIntraspinal injectionOligodendrocyte glycoproteinRecombinant rat myelin oligodendrocyte glycoproteinCentral nervous system locationsGrowth factorSensitized T cellsFocal experimental autoimmune encephalomyelitisRat myelin oligodendrocyte glycoproteinSite of injectionMyelin-forming cellsMOG immunizationExtensive demyelinationLymphocyte infiltration
2003
Rat and Human Myelin Oligodendrocyte Glycoproteins Induce Experimental Autoimmune Encephalomyelitis by Different Mechanisms in C57BL/6 Mice
Oliver AR, Lyon GM, Ruddle NH. Rat and Human Myelin Oligodendrocyte Glycoproteins Induce Experimental Autoimmune Encephalomyelitis by Different Mechanisms in C57BL/6 Mice. The Journal Of Immunology 2003, 171: 462-468. PMID: 12817031, DOI: 10.4049/jimmunol.171.1.462.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigen PresentationAutoantibodiesB-LymphocytesCell MovementDose-Response Relationship, ImmunologicEncephalomyelitis, Autoimmune, ExperimentalFemaleGlycoproteinsHumansImmunoglobulin GInjections, IntramuscularInterferon-gammaInterleukin-13MiceMice, Inbred C57BLMice, Mutant StrainsMolecular Sequence DataMyelin-Oligodendrocyte GlycoproteinPeptide FragmentsRatsSpecies SpecificitySpinal CordConceptsExperimental autoimmune encephalomyelitisMyelin oligodendrocyte glycoproteinRat myelin oligodendrocyte glycoproteinHuman myelin oligodendrocyte glycoproteinMOG 35C57BL/6 miceMOG proteinAutoimmune encephalomyelitisOligodendrocyte glycoproteinB cellsCell responsesEncephalitogenic T cell responsesB cell-deficient miceB cell dependenceCell-deficient miceT cell responsesB cell responsesDifferent pathogenic mechanismsCNS infiltratesIL-13T cellsSpleen cellsIFN-gammaIgG subclassesAg presentation
2001
Resident and Infiltrating Central Nervous System APCs Regulate the Emergence and Resolution of Experimental Autoimmune Encephalomyelitis
Juedes A, Ruddle N. Resident and Infiltrating Central Nervous System APCs Regulate the Emergence and Resolution of Experimental Autoimmune Encephalomyelitis. The Journal Of Immunology 2001, 166: 5168-5175. PMID: 11290800, DOI: 10.4049/jimmunol.166.8.5168.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntigen PresentationAntigen-Presenting CellsB7-1 AntigenBrainCell LineCell MovementDown-RegulationEncephalomyelitis, Autoimmune, ExperimentalFemaleGrowth InhibitorsHistocompatibility Antigens Class IHistocompatibility Antigens Class IILymphocyte ActivationMacromolecular SubstancesMacrophagesMiceMice, Inbred C57BLMice, KnockoutMicrogliaMolecular Sequence DataMyelin ProteinsMyelin-Associated GlycoproteinMyelin-Oligodendrocyte GlycoproteinNitric OxideSpinal CordT-LymphocytesConceptsExperimental autoimmune encephalomyelitisT cell proliferationT cellsT cell linesCNS APCCNS APCsAutoimmune encephalomyelitisMHC-IITarget organsInducible NO synthase-deficient miceT cell cytokine productionTh1 T cellsAutoreactive T cellsCell cytokine productionIFN-gamma productionB7-1 expressionSynthase-deficient miceCell proliferationMac-1 cellsCell linesInitiation of diseaseProduction of NOResident microgliaMyelin oligodendrocyteCytokine production
1997
A Critical Role for Lymphotoxin in Experimental Allergic Encephalomyelitis
Suen W, Bergman C, Hjelmström P, Ruddle N. A Critical Role for Lymphotoxin in Experimental Allergic Encephalomyelitis. Journal Of Experimental Medicine 1997, 186: 1233-1240. PMID: 9334362, PMCID: PMC2199100, DOI: 10.1084/jem.186.8.1233.Peer-Reviewed Original ResearchConceptsExperimental allergic encephalomyelitisMaximum clinical scoreMyelin oligodendrocyte glycoproteinClinical scoresLT-alphaAllergic encephalomyelitisMultiple sclerosisCentral nervous system inflammationNervous system inflammationT cell productionDisease multiple sclerosisRat myelin oligodendrocyte glycoproteinAverage clinical scoreDisease indexWild-type littermatesWT T cellsNecrosis factor familyMOG 35CNS inflammationMOG antibodiesSystem inflammationWT miceC57BL/6 miceOligodendrocyte glycoproteinTNF-alpha
1971
Experimental autoallergic encephalomyelitis and cellular hypersensitivity in vitro.
Ellison G, Waksman B, Ruddle N. Experimental autoallergic encephalomyelitis and cellular hypersensitivity in vitro. Neurology 1971, 21: 778-82. PMID: 5106293, DOI: 10.1212/wnl.21.8.778.Peer-Reviewed Original Research