2002
Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ
Constant SL, Brogdon JL, Piggott DA, Herrick CA, Visintin I, Ruddle NH, Bottomly K. Resident lung antigen-presenting cells have the capacity to promote Th2 T cell differentiation in situ. Journal Of Clinical Investigation 2002, 110: 1441-1448. PMID: 12438442, PMCID: PMC151814, DOI: 10.1172/jci16109.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntranasalAnimalsAntigen PresentationAntigen-Presenting CellsAntigens, ProtozoanCD4-Positive T-LymphocytesCell DifferentiationCell MovementCytokinesInterleukin-10Interleukin-6Leishmania majorLungLymph NodesLymphotoxin-alphaMiceMice, Inbred C57BLMice, KnockoutTh1 CellsTh2 CellsConceptsAntigen-presenting cellsTh2 T cell differentiationT cell primingT cell differentiationCell primingAntigen-loaded antigen-presenting cellsLung antigen-presenting cellsPulmonary antigen-presenting cellsResident antigen-presenting cellsPreferential primingAntigen-specific T cellsSecondary lymphoid organsTh2-dominated responsesTh1 responseAntigen exposureIL-10Th2 typeAntigen uptakeIL-6Lung microenvironmentLymphoid organsTh2 cellsIntranasal deliveryLung tissueAirway epithelium
2000
Lymphotoxin in inflammation and lymphoid organ development: Variations on a theme
Ruddle N. Lymphotoxin in inflammation and lymphoid organ development: Variations on a theme. Progress In Inflammation Research 2000, 83-88. DOI: 10.1007/978-3-0348-8468-6_8.Peer-Reviewed Original ResearchAutoimmune diseasesLymphoid organsLymphoid organ developmentT cellsTarget organsAntigen-specific T cellsAdditional T cellsLocal lymphoid organsTertiary lymphoid organsConsequence of inflammationLymphoid neogenesisClinical relapseAutoimmune inflammationLocal target organLymphoid tissueInflammatory reactionB cellsInflammationTransgenic miceTissue damageDiseaseTNF familyOrgansUnrelated moleculesOrgan development