2010
Preeclampsia-related increase of interleukin-11 expression in human decidual cells
Basar M, Yen CF, Buchwalder LF, Murk W, Huang SJ, Godlewski K, Kocamaz E, Arda O, Schatz F, Lockwood CJ, Kayisli UA. Preeclampsia-related increase of interleukin-11 expression in human decidual cells. Reproduction 2010, 140: 605-612. PMID: 20668109, PMCID: PMC3795512, DOI: 10.1530/rep-10-0263.Peer-Reviewed Original ResearchMeSH KeywordsAdultDeciduaEstradiolFemaleHumansImidazolesImmunohistochemistryInterleukin-11Interleukin-1betaNaphthalenesNF-kappa BP38 Mitogen-Activated Protein KinasesPre-EclampsiaPregnancyProtein Kinase CPyridinesReverse Transcriptase Polymerase Chain ReactionRNA, MessengerStatistics, NonparametricTumor Necrosis Factor-alphaConceptsFirst trimester decidual cellsDecidual cellsPlacental sectionsLeukocyte-free first trimester decidual cellsGestational age-matched controlsProtein kinase CMaternal-placental interfaceUteroplacental blood flowPathogenesis of preeclampsiaAnti-inflammatory processesCultured decidual cellsTumor necrosis factorAge-matched controlsHuman decidual cellsQuantitative RT-PCRSystemic inflammationNecrosis factorPreeclampsiaBlood flowP38 MAP kinaseIL11 expressionNuclear factorStimulatory effectIL11RT-PCR
2008
Preeclampsia-Related Inflammatory Cytokines Regulate Interleukin-6 Expression in Human Decidual Cells
Lockwood CJ, Yen CF, Basar M, Kayisli UA, Martel M, Buhimschi I, Buhimschi C, Huang SJ, Krikun G, Schatz F. Preeclampsia-Related Inflammatory Cytokines Regulate Interleukin-6 Expression in Human Decidual Cells. American Journal Of Pathology 2008, 172: 1571-1579. PMID: 18467705, PMCID: PMC2408417, DOI: 10.2353/ajpath.2008.070629.Peer-Reviewed Original ResearchConceptsIL-6 levelsIL-6Decidual cellsGestational age-matched control placentasElevated IL-6 levelsIL-6 mRNA levelsCommon pregnancy disorderGenesis of preeclampsiaUteroplacental blood flowFetal-placental unitInterleukin-6 levelsPathogenesis of preeclampsiaPro-inflammatory cytokinesEndothelial cell dysfunctionInterleukin-6 expressionHuman decidual cellsReal-time quantitative RT-PCRTime quantitative RT-PCRQuantitative RT-PCRFetal morbidityDecidual macrophagesPreeclamptic womenSystemic inflammationPregnancy disordersControl placentas