Comparison of the Mitophagy and Apoptosis Related Gene Expressions in Waste Embryo Culture Medium of Female Infertility Types
Kütük D, Öner Ç, Başar M, Akcay B, Olcay İ, Çolak E, Selam B, Cincik M. Comparison of the Mitophagy and Apoptosis Related Gene Expressions in Waste Embryo Culture Medium of Female Infertility Types. Life 2024, 14: 1507. PMID: 39598305, PMCID: PMC11595419, DOI: 10.3390/life14111507.Peer-Reviewed Original ResearchPolycystic ovary syndromePoor ovarian reservePINK1 gene expressionGene expressionOocyte-to-embryo transitionEmbryo culture fluidApoptosis related gene expressionNormorespondersIVF centerInfertility typeCellular parametersMitochondrial DNAP53 gene expressionOvarian reserveFemale infertilityRelated gene expressionPINK1HumaninMitochondrial dysfunctionReal time PCRMfn2Embryonic development periodInfertile patientsMfn1Culture fluidMitochondrial Unfolded Protein Response Gene Clpp Is Required for Oocyte Function and Female Fertility
Ergun Y, Imamoglu A, Cozzolino M, Demirkiran C, Basar M, Garg A, Yildirim R, Seli E. Mitochondrial Unfolded Protein Response Gene Clpp Is Required for Oocyte Function and Female Fertility. International Journal Of Molecular Sciences 2024, 25: 1866. PMID: 38339144, PMCID: PMC10855406, DOI: 10.3390/ijms25031866.Peer-Reviewed Original ResearchConceptsCaseinolytic peptidase PMouse modelProtein homeostasisStress responseUnfolded protein stress responseProtein stress responseCumulus/granulosa cellsOocyte competenceOocyte functionGlobal deletionFunctional abnormalitiesGenes clpPMetabolic stress responseFemale subfertilityFemale infertilityOocyte-specificOocytesReproductive functionMtUPRMiceProtein degradationReproductive competenceFemale fertilityDeletionHomeostasis