2024
Opioid Dose Variation in Cardiac Surgery: A Multicenter Study of Practice.
Fisher C, Janda A, Zhao X, Deng Y, Bardia A, Yanez N, Burns M, Aziz M, Treggiari M, Mathis M, Lin H, Schonberger R. Opioid Dose Variation in Cardiac Surgery: A Multicenter Study of Practice. Anesthesia & Analgesia 2024 PMID: 39167548, DOI: 10.1213/ane.0000000000007128.Peer-Reviewed Original ResearchCardiac surgeryOpioid doseDose variationIntraoperative opioid administrationIntraoperative opioid doseHigh-dose opioidsAdult cardiac surgerySurgical differencesOpioid-freeOpioid administrationOpioid useMultimodal analgesiaAnalgesic techniquesCardiopulmonary bypassMulticenter studyFentanyl equivalentsSufentanil infusionSurgical patientsOpioidSurgeryAnesthetic techniqueCardiac casesAttending anesthesiologistPatientsDoseAssociation of early dexmedetomidine exposure with brain injury biomarker levels following moderate – Severe traumatic brain injury: A TRACK-TBI study
Wongsripuemtet P, Ohnuma T, Temkin N, Barber J, Komisarow J, Manley G, Hatfield J, Treggiari M, Colton K, Sasannejad C, Chaikittisilpa N, Ivins-O’Keefe K, Grandhi R, Laskowitz D, Mathew J, Hernandez A, James M, Raghunathan K, Miller J, Vavilala M, Krishnamoorthy V, investigators T. Association of early dexmedetomidine exposure with brain injury biomarker levels following moderate – Severe traumatic brain injury: A TRACK-TBI study. Journal Of Clinical Neuroscience 2024, 126: 338-347. PMID: 39029302, DOI: 10.1016/j.jocn.2024.07.003.Peer-Reviewed Original ResearchConceptsC-reactive proteinNeuron-specific enolaseGlial fibrillary acidic proteinBiomarker levelsUbiquitin C-terminal hydrolase-L1Traumatic brain injuryDexmedetomidine exposureInjury biomarkersSevere traumatic brain injuryTRACK-TBIS100 calcium-binding protein BInflammatory biomarkers C-reactive proteinCalcium-binding protein BHs-CRP levelsLevel 1 trauma centerRetrospective cohort studyCritically ill TBI patientsAlpha-2 agonistsBrain injuryBrain injury biomarkersBiomarkers C-reactive proteinModulate autonomic functionGlasgow Coma Scale score 3No significant associationSecondary brain injuryUse of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study
Royce-Nagel G, Jarzebowski M, Wongsripuemtet P, Krishnamoorthy V, Fuller M, Ohnuma T, Treggiari M, Yaport M, Cobert J, Garrigan E, Bartz R, Raghunathan K. Use of Early Ketamine Sedation and Association With Clinical and Cost Outcomes Among Mechanically Ventilated Patients With COVID-19: A Retrospective Cohort Study. Critical Care Explorations 2024, 6: e1105. PMID: 38904975, PMCID: PMC11196078, DOI: 10.1097/cce.0000000000001105.Peer-Reviewed Original ResearchConceptsRenal replacement therapyLength of stayHospital length of stayHigher hospital mortalityKetamine infusionTotal hospital costsHospital mortalityVasopressor daysKetamine useVentilator daysSample of U.S. hospitalsRenal replacement therapy useAssociated with higher hospital mortalityDays of mechanical ventilationAssociated with in-hospital mortalityHospital costsManagement of critically ill patientsExtracorporeal membrane oxygenationPropensity score matching analysisRetrospective cohort studyPremier Healthcare DatabaseDays of hospitalizationDays of intubationMechanically ventilated patientsCritically ill patientsDesign and implementation of community consultation for research conducted under exception from informed consent regulations for the PreVent and the PreVent 2 trials: Changes over time and during the COVID-19 pandemic
Gugel T, Adams K, Baranoski M, Yanez N, Kampp M, Johnson T, Aydin A, Fajardo E, Sharp E, Potnis A, Johnson C, Treggiari M. Design and implementation of community consultation for research conducted under exception from informed consent regulations for the PreVent and the PreVent 2 trials: Changes over time and during the COVID-19 pandemic. Clinical Trials 2024, 21: 671-680. PMID: 38676438, PMCID: PMC11512686, DOI: 10.1177/17407745241243045.Peer-Reviewed Original ResearchPublic disclosure activitiesCommunity consultationInstitutional review boardConsent regulationsIn-personEmergency researchRegulatory measuresCOVID-19 pandemicPublic disclosureSponsor-investigatorsPublic supportPrevention experimentsCommunity leadersIn-person eventsYear of implementationFood and Drug AdministrationHigher education levelCommunity concernsReview boardSelection biasProportion of respondentsMethod of contactClinical researchLocal communitiesCOVID-19Contemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist
Robba C, Busl K, Claassen J, Diringer M, Helbok R, Park S, Rabinstein A, Treggiari M, Vergouwen M, Citerio G. Contemporary management of aneurysmal subarachnoid haemorrhage. An update for the intensivist. Intensive Care Medicine 2024, 50: 646-664. PMID: 38598130, PMCID: PMC11078858, DOI: 10.1007/s00134-024-07387-7.Peer-Reviewed Original ResearchConceptsIntensive care unitAneurysmal subarachnoid haemorrhageRuptured aneurysmsLong-term prognostic factorsRisk of rebleedingIntensive care unit managementRobust clinical evidenceDelayed cerebral ischaemiaExpert clinical experienceSecondary brain damageDeterminants of functional outcomePrognostic factorsASAH patientsPrompt diagnosisHaemodynamic monitoringClinical evidenceMorbidity rateSpecialized centersTreatment strategiesClinical trialsContemporary guidelinesPatient populationFunctional outcomesCare unitCerebral ischaemiaThe role of Advance Directives and Living Wills in Anesthesia Practice
Devinney M, Treggiari M. The role of Advance Directives and Living Wills in Anesthesia Practice. Anesthesiology Clinics 2024, 42: 377-392. PMID: 39054014, DOI: 10.1016/j.anclin.2024.02.001.Peer-Reviewed Original ResearchEarly Beta-Blocker Utilization in Critically Ill Patients With Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study
Kelly-Hedrick M, Liu S, Komisarow J, Hatfield J, Ohnuma T, Treggiari M, Colton K, Arulraja E, Vavilala M, Laskowitz D, Mathew J, Hernandez A, James M, Raghunathan K, Krishnamoorthy V. Early Beta-Blocker Utilization in Critically Ill Patients With Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study. Journal Of Intensive Care Medicine 2024, 39: 875-882. PMID: 38449336, DOI: 10.1177/08850666241236724.Peer-Reviewed Original ResearchAssociated with hospital mortalityRetrospective cohort studyLength of stayModerate-severe TBITraumatic brain injuryCohort studyIntensive care unitBeta-blocker classHospital mortalityUtilization patternsClaims-based datasetHospital length of stayIll patientsCritically ill patientsIntensive care unit length of stayBrain injuryBeta-blockersHealthcare databasesInclusion criteriaSecondary outcomesPremier Healthcare DatabasePrimary outcomeVasopressor utilizationIntensive care unit stayHospitalSoft phenotyping for sepsis via EHR time-aware soft clustering
Jiang S, Gai X, Treggiari M, Stead W, Zhao Y, Page C, Zhang A. Soft phenotyping for sepsis via EHR time-aware soft clustering. Journal Of Biomedical Informatics 2024, 152: 104615. PMID: 38423266, PMCID: PMC11073833, DOI: 10.1016/j.jbi.2024.104615.Peer-Reviewed Original ResearchElectronic health recordsRecovery trajectoriesSub-phenotypesHealth recordsClustering algorithmTiming of interventionLogistic regressionCondition associated with high mortalitySoft clustering algorithmDisease sub-phenotypesSepsis prediction modelSoft clusteringClinical variablesOptimal timing of interventionTemporal informationMedical plausibilityHigher mortalityClustering procedureAccurate informationOrgan dysfunctionAlgorithmDysregulated immune response to infectionInterventionHospitalSepsis-related organ dysfunctionAssociation of Early Dexmedetomidine Utilization With Clinical Outcomes After Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study
Liu S, Kelly-Hedrick M, Komisarow J, Hatfield J, Ohnuma T, Treggiari M, Colton K, Arulraja E, Vavilala M, Laskowitz D, Mathew J, Hernandez A, James M, Raghunathan K, Krishnamoorthy V. Association of Early Dexmedetomidine Utilization With Clinical Outcomes After Moderate-Severe Traumatic Brain Injury: A Retrospective Cohort Study. Anesthesia & Analgesia 2024, 139: 366-374. PMID: 38335145, PMCID: PMC11250935, DOI: 10.1213/ane.0000000000006869.Peer-Reviewed Original ResearchLength of stayTraumatic brain injuryImprove patient outcomesModerate-severe TBIRetrospective cohort studyMechanical ventilationMechanically ventilated patientsDexmedetomidine exposureDay of admissionCohort studyHospital mortalityOdds of hospital mortalityPatient outcomesAssociated with reduced oddsCohort of critically ill adult patientsPrimary outcome of hospital mortalityReduce length of stayHospital costsAssociated with oddsOutcome of hospital mortalityCritically ill adult patientsDay of ICU admissionHospital length of stayIll adult patientsPublic health problem
2023
Association of Early Dexmedetomidine Utilization With Clinical and Functional Outcomes Following Moderate-Severe Traumatic Brain Injury: A Transforming Clinical Research and Knowledge in Traumatic Brain Injury Study*
Liu S, Kelly-Hedrick M, Temkin N, Barber J, Komisarow J, Hatfield J, Ohnuma T, Manley G, Treggiari M, Colton K, Vavilala M, Grandhi R, Laskowitz D, Mathew J, Hernandez A, James M, Raghunathan K, Goldstein B, Markowitz A, Krishnamoorthy V, Investigators T. Association of Early Dexmedetomidine Utilization With Clinical and Functional Outcomes Following Moderate-Severe Traumatic Brain Injury: A Transforming Clinical Research and Knowledge in Traumatic Brain Injury Study*. Critical Care Medicine 2023, 52: 607-617. PMID: 37966330, PMCID: PMC10939970, DOI: 10.1097/ccm.0000000000006106.Peer-Reviewed Original ResearchModerate-severe traumatic brain injuryDisability Rating ScaleDexmedetomidine exposureHours of admissionTraumatic brain injuryFunctional outcomeHospital stayMechanical ventilationBrain injuryICP monitoringGlasgow Outcome Scale-ExtendedLevel 1 trauma centerClinical researchSevere traumatic brain injuryTraumatic Brain Injury (CENTER-TBI) studyFollowing secondary outcomesRetrospective cohort studySecond-line agentsPropensity-weighted modelsBrain Injury StudyLower DRS scoresEarly dexmedetomidineHospital mortalitySedation choiceUnexposed patients
2022
Pain, Analgesic Use, and Patient Satisfaction With Spinal Versus General Anesthesia for Hip Fracture Surgery : A Randomized Clinical Trial.
Neuman MD, Feng R, Ellenberg SS, Sieber F, Sessler DI, Magaziner J, Elkassabany N, Schwenk ES, Dillane D, Marcantonio ER, Menio D, Ayad S, Hassan M, Stone T, Papp S, Donegan D, Marshall M, Jaffe JD, Luke C, Sharma B, Azim S, Hymes R, Chin KJ, Sheppard R, Perlman B, Sappenfield J, Hauck E, Hoeft MA, Tierney A, Gaskins LJ, Horan AD, Brown T, Dattilo J, Carson JL, Looke T, Bent S, Franco-Mora A, Hedrick P, Newbern M, Tadros R, Pealer K, Vlassakov K, Buckley C, Gavin L, Gorbatov S, Gosnell J, Steen T, Vafai A, Zeballos J, Hruslinski J, Cardenas L, Berry A, Getchell J, Quercetti N, Bajracharya G, Billow D, Bloomfield M, Cuko E, Elyaderani MK, Hampton R, Honar H, Khoshknabi D, Kim D, Krahe D, Lew MM, Maheshwer CB, Niazi A, Saha P, Salih A, de Swart RJ, Volio A, Bolkus K, DeAngelis M, Dodson G, Gerritsen J, McEniry B, Mitrev L, Kwofie MK, Belliveau A, Bonazza F, Lloyd V, Panek I, Dabiri J, Chavez C, Craig J, Davidson T, Dietrichs C, Fleetwood C, Foley M, Getto C, Hailes S, Hermes S, Hooper A, Koener G, Kohls K, Law L, Lipp A, Losey A, Nelson W, Nieto M, Rogers P, Rutman S, Scales G, Sebastian B, Stanciu T, Lobel G, Giampiccolo M, Herman D, Kaufman M, Murphy B, Pau C, Puzio T, Veselsky M, Apostle K, Boyer D, Fan BC, Lee S, Lemke M, Merchant R, Moola F, Payne K, Perey B, Viskontas D, Poler M, D'Antonio P, O'Neill G, Abdullah A, Fish-Fuhrmann J, Giska M, Fidkowski C, Guthrie ST, Hakeos W, Hayes L, Hoegler J, Nowak K, Beck J, Cuff J, Gaski G, Haaser S, Holzman M, Malekzadeh AS, Ramsey L, Schulman J, Schwartzbach C, Azefor T, Davani A, Jaberi M, Masear C, Haider SB, Chungu C, Ebrahimi A, Fikry K, Marcantonio A, Shelvan A, Sanders D, Clarke C, Lawendy A, Schwartz G, Garg M, Kim J, Caruci J, Commeh E, Cuevas R, Cuff G, Franco L, Furgiuele D, Giuca M, Allman M, Barzideh O, Cossaro J, D'Arduini A, Farhi A, Gould J, Kafel J, Patel A, Peller A, Reshef H, Safur M, Toscano F, Tedore T, Akerman M, Brumberger E, Clark S, Friedlander R, Jegarl A, Lane J, Lyden JP, Mehta N, Murrell MT, Painter N, Ricci W, Sbrollini K, Sharma R, Steel PAD, Steinkamp M, Weinberg R, Wellman DS, Nader A, Fitzgerald P, Ritz M, Bryson G, Craig A, Farhat C, Gammon B, Gofton W, Harris N, Lalonde K, Liew A, Meulenkamp B, Sonnenburg K, Wai E, Wilkin G, Troxell K, Alderfer ME, Brannen J, Cupitt C, Gerhart S, McLin R, Sheidy J, Yurick K, Chen F, Dragert K, Kiss G, Malveaux H, McCloskey D, Mellender S, Mungekar SS, Noveck H, Sagebien C, Biby L, McKelvy G, Richards A, Abola R, Ayala B, Halper D, Mavarez A, Rizwan S, Choi S, Awad I, Flynn B, Henry P, Jenkinson R, Kaustov L, Lappin E, McHardy P, Singh A, Donnelly J, Gonzalez M, Haydel C, Livelsberger J, Pazionis T, Slattery B, Vazquez-Trejo M, Baratta J, Cirullo M, Deiling B, Deschamps L, Glick M, Katz D, Krieg J, Lessin J, Mojica J, Torjman M, Jin R, Salpeter MJ, Powell M, Simmons J, Lawson P, Kukreja P, Graves S, Sturdivant A, Bryant A, Crump SJ, Verrier M, Green J, Menon M, Applegate R, Arias A, Pineiro N, Uppington J, Wolinsky P, Gunnett A, Hagen J, Harris S, Hollen K, Holloway B, Horodyski MB, Pogue T, Ramani R, Smith C, Woods A, Warrick M, Flynn K, Mongan P, Ranganath Y, Fernholz S, Ingersoll-Weng E, Marian A, Seering M, Sibenaller Z, Stout L, Wagner A, Walter A, Wong C, Orwig D, Goud M, Helker C, Mezenghie L, Montgomery B, Preston P, Schwartz JS, Weber R, Fleisher LA, Mehta S, Stephens-Shields AJ, Dinh C, Chelly JE, Goel S, Goncz W, Kawabe T, Khetarpal S, Monroe A, Shick V, Breidenstein M, Dominick T, Friend A, Mathews D, Lennertz R, Sanders R, Akere H, Balweg T, Bo A, Doro C, Goodspeed D, Lang G, Parker M, Rettammel A, Roth M, White M, Whiting P, Allen BFS, Baker T, Craven D, McEvoy M, Turnbo T, Kates S, Morgan M, Willoughby T, Weigel W, Auyong D, Fox E, Welsh T, Cusson B, Dobson S, Edwards C, Harris L, Henshaw D, Johnson K, McKinney G, Miller S, Reynolds J, Segal BS, Turner J, VanEenenaam D, Weller R, Lei J, Treggiari M, Akhtar S, Blessing M, Johnson C, Kampp M, Kunze K, O'Connor M, Looke T, Tadros R, Vlassakov K, Cardenas L, Bolkus K, Mitrev L, Kwofie MK, Dabiri J, Lobel G, Poler M, Giska M, Sanders D, Schwartz G, Giuca M, Tedore T, Nader A, Bryson G, Troxell K, Kiss G, Choi S, Powell M, Applegate R, Warrick M, Ranganath Y, Chelly JE, Lennertz R, Sanders R, Allen BFS, Kates S, Weigel W, Li J, Wijeysundera DN, Kheterpal S, Moore RH, Smith AK, Tosi LL, Looke T, Mehta S, Fleisher L, Hruslinski J, Ramsey L, Langlois C, Mezenghie L, Montgomery B, Oduwole S, Rose T. Pain, Analgesic Use, and Patient Satisfaction With Spinal Versus General Anesthesia for Hip Fracture Surgery : A Randomized Clinical Trial. Annals Of Internal Medicine 2022, 175: 952-960. PMID: 35696684, DOI: 10.7326/M22-0320.Peer-Reviewed Original ResearchPharmacokinetics and Tolerability of Intraperitoneal Chloroprocaine After Fetal Extraction in Women Undergoing Cesarean Delivery
Togioka BM, Zarnegarnia Y, Bleyle LA, Koop D, Brookfield K, Yanez ND, Treggiari MM. Pharmacokinetics and Tolerability of Intraperitoneal Chloroprocaine After Fetal Extraction in Women Undergoing Cesarean Delivery. Anesthesia & Analgesia 2022, 135: 777-786. PMID: 35544759, DOI: 10.1213/ane.0000000000006064.Peer-Reviewed Original ResearchConceptsLocal anesthetic systemic toxicityPeak plasma concentrationCesarean deliveryPlasma concentrationsSystemic toxicityIntraperitoneal administrationFetal extractionMultiple-dose escalation studyPatient drug exposureMaternal blood samplesMaximum plasma concentrationRoute of administrationYears of ageClinical tolerabilityEscalation studySpinal anesthesiaUterine closureNeuraxial anesthesiaClinical symptomsDrug exposureClinical signsWomen 18Prospective assessmentBlood samplesPharmacokinetic profile
2021
A Double-Blind, Randomized, Placebo-Controlled Trial of Soluble Epoxide Hydrolase Inhibition in Patients with Aneurysmal Subarachnoid Hemorrhage
Martini RP, Siler D, Cetas J, Alkayed NJ, Allen E, Treggiari MM. A Double-Blind, Randomized, Placebo-Controlled Trial of Soluble Epoxide Hydrolase Inhibition in Patients with Aneurysmal Subarachnoid Hemorrhage. Neurocritical Care 2021, 36: 905-915. PMID: 34873674, DOI: 10.1007/s12028-021-01398-8.Peer-Reviewed Original ResearchConceptsSoluble epoxide hydrolaseAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageDHET ratiosEnd pointDay 7Day 10Primary study end pointSoluble epoxide hydrolase inhibitionCSF inflammatory cytokinesEET/DHET ratiosIncidence of DCIPrevention of DCITertiary end pointSecondary end pointsStudy end pointCerebral blood flowLength of stayEndothelial injury biomarkersEpoxide hydrolase inhibitionNeurovascular inflammationResultsTen patientsStudy drugAdverse eventsCytokine levelsAdherence to Guidelines for the Administration of Intraoperative Antibiotics in a Nationwide US Sample
Bardia A, Treggiari MM, Michel G, Dai F, Tickoo M, Wai M, Schuster K, Mathis M, Shah N, Kheterpal S, Schonberger RB. Adherence to Guidelines for the Administration of Intraoperative Antibiotics in a Nationwide US Sample. JAMA Network Open 2021, 4: e2137296. PMID: 34905007, PMCID: PMC8672234, DOI: 10.1001/jamanetworkopen.2021.37296.Peer-Reviewed Original ResearchConceptsSurgical site infectionAntibiotic prophylaxis guidelinesWeight-adjusted dosingInfectious Diseases SocietyAntibiotic choiceProphylaxis guidelinesCohort studyDiseases SocietyOverall adherenceFuture quality improvement effortsStudy periodAntibiotic administration guidelinesPrimary end pointTiming of administrationGynecological surgical proceduresQuality improvement effortsIntraoperative antibioticsOverall nonadherenceNoncardiac surgeryAdult patientsEmergency surgeryFirst doseGuideline adherenceSurgical encountersAmerica guidelinesTreatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study
Zhao X, Gao C, Dai F, Treggiari MM, Deshpande R, Meng L. Treatments Associated with Lower Mortality among Critically Ill COVID-19 Patients: A Retrospective Cohort Study. Anesthesiology 2021, 135: 1076-1090. PMID: 34597362, DOI: 10.1097/aln.0000000000003999.Peer-Reviewed Original ResearchConceptsIll COVID-19 patientsCOVID-19 patientsPropensity score-matched analysisRetrospective cohort studyLower mortalityHospital mortalityCohort studyMultivariable analysisYale New Haven Health SystemIntensive care unit admissionOrgan support treatmentUse of apixabanCare unit admissionSevere COVID-19Intensive care unitCOVID-19 mortalityLower COVID-19 mortalityApixaban treatmentUnit admissionAspirin treatmentCare unitTreatment AssociatedCandidate treatmentSupport treatmentPatientsEarly but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19
Briggs N, Gormally MV, Li F, Browning SL, Treggiari MM, Morrison A, Laurent-Rolle M, Deng Y, Hendrickson JE, Tormey CA, Desruisseaux MS. Early but not late convalescent plasma is associated with better survival in moderate-to-severe COVID-19. PLOS ONE 2021, 16: e0254453. PMID: 34320004, PMCID: PMC8318280, DOI: 10.1371/journal.pone.0254453.Peer-Reviewed Original ResearchConceptsCOVID-19 convalescent plasmaSevere COVID-19Convalescent plasmaPlasma recipientsHospital mortalityUnexposed cohortCCP administrationSevere COVID-19 infectionPropensity score-matched analysisCOVID-19Limited therapeutic optionsCOVID-19 infectionCoronavirus disease 2019CCP recipientsHospital stayPrimary endpointSecondary endpointsHospital daysHospital dischargeEarly administrationComplete followMechanical ventilationTherapeutic optionsClinical differencesSevere diseaseFactor VIII inhibitor bypass activity (FEIBA) for the reduction of transfusion in cardiac surgery: a randomized, double-blind, placebo-controlled, pilot trial
Sera VA, Stevens AE, Song HK, Rodriguez VM, Tibayan FA, Treggiari MM. Factor VIII inhibitor bypass activity (FEIBA) for the reduction of transfusion in cardiac surgery: a randomized, double-blind, placebo-controlled, pilot trial. Pilot And Feasibility Studies 2021, 7: 137. PMID: 34215339, PMCID: PMC8252226, DOI: 10.1186/s40814-021-00873-5.Peer-Reviewed Original ResearchFactor Eight Inhibitor Bypassing ActivityCardiac surgeryPilot trialTransfusion requirementsRescue therapyLarge trialsProtocol adherenceBlood productsHigh-risk cardiac surgeryProthrombin complex concentrate administrationPlacebo-controlled pilot trialFactor VIII inhibitor bypass activityLarge pivotal trialsReduction of transfusionBlood product transfusionEnd of CPBTertiary referral hospitalHypothermic circulatory arrestTermination of CPBPost-cardiopulmonary bypassProthrombin complex concentrateBlinded administrationProduct transfusionResultsTwenty patientsStudy drugThe Role of Anesthesiologists in Perioperative Limitation of Potentially Life-Sustaining Medical Treatments: A Narrative Review and Perspective
Cushman T, Waisel DB, Treggiari MM. The Role of Anesthesiologists in Perioperative Limitation of Potentially Life-Sustaining Medical Treatments: A Narrative Review and Perspective. Anesthesia & Analgesia 2021, 133: 663-675. PMID: 34014183, DOI: 10.1213/ane.0000000000005559.Peer-Reviewed Original ResearchConceptsLife-sustaining medical treatmentPerioperative careMedical treatmentPerioperative Registered NursesImmediate perioperative periodGoals of careGoal-concordant careDaily clinical practiceRole of anesthesiologistsPrimary care colleaguesPerioperative periodElective surgeryGeneral anesthesiaCare discussionsResuscitate ordersPatient's wishesAmerican CollegeClinical practiceRegistered NursesNarrative reviewPhysiologic homeostasisAnesthesiologistsCareAmerican SocietyPatient autonomyAssisted Fluid Management Software Guidance for Intraoperative Fluid Administration
Maheshwari K, Malhotra G, Bao X, Lahsaei P, Hand WR, Fleming NW, Ramsingh D, Treggiari MM, Sessler DI, Miller TE. Assisted Fluid Management Software Guidance for Intraoperative Fluid Administration. Anesthesiology 2021, 135: 273-283. PMID: 33901281, DOI: 10.1097/aln.0000000000003790.Peer-Reviewed Original ResearchConceptsFluid administrationFluid bolusStroke volumeNoncardiac surgeryHigh-risk noncardiac surgeryGoal-directed managementInadequate fluid administrationIntraoperative fluid administrationArterial catheter insertionIntravenous fluid administrationIntraoperative fluid managementCatheter insertionCohort evaluationMechanical ventilationFluid responsivenessFluid managementSD increaseFluid strategySurgeryBolusCliniciansAdministrationSV increaseExploratory basisMulticenterAnesthesia for Acute Spinal Cord Injury
Rao S, Treggiari MM. Anesthesia for Acute Spinal Cord Injury. Anesthesiology Clinics 2021, 39: 127-138. PMID: 33563376, DOI: 10.1016/j.anclin.2020.11.011.Peer-Reviewed Original ResearchConceptsAcute spinal cord injurySpinal cord injuryCord injurySpinal cordSpinal cord perfusion pressureImportant anesthetic implicationsAcute hemodynamic changesLong-term morbidityLoss of bowelLevel of injuryFirst lumbar vertebraVentilator dependenceAirway stabilizationCord compressionSurgical emergencyBladder functionRespiratory musclesAnesthetic implicationsHemodynamic changesPerfusion pressureCauda equinaFluid managementInjuryLumbar vertebraeMorbidity