2014
Assessment of Circulating Blood Volume with Fluid Administration Targeting Euvolemia or Hypervolemia
Joffe AM, Khandelwal N, Hallman MR, Treggiari MM. Assessment of Circulating Blood Volume with Fluid Administration Targeting Euvolemia or Hypervolemia. Neurocritical Care 2014, 22: 82-88. PMID: 25142828, DOI: 10.1007/s12028-014-9993-8.Peer-Reviewed Original ResearchConceptsSubgroup of patientsBlood volumeHV groupDay 5Fluid administrationFluid balanceDelayed ischemic neurologic deficitsCrystalloid fluid administrationIschemic neurologic deficitCumulative fluid balanceML/Higher fluid balanceT-testStudent's t-testProphylactic hypervolemiaICU admissionICU stayResultsTwenty patientsNeurologic deficitsCerebral vasospasmClinical trialsHypervolemiaNormovolemiaBVA-100Concurrent groupImproved Analgesia, Sedation, and Delirium Protocol Associated with Decreased Duration of Delirium and Mechanical Ventilation
Dale CR, Kannas DA, Fan VS, Daniel SL, Deem S, Yanez ND, Hough CL, Dellit TH, Treggiari MM. Improved Analgesia, Sedation, and Delirium Protocol Associated with Decreased Duration of Delirium and Mechanical Ventilation. Annals Of The American Thoracic Society 2014, 11: 367-374. PMID: 24597599, PMCID: PMC4028734, DOI: 10.1513/annalsats.201306-210oc.Peer-Reviewed Original ResearchConceptsCAM-ICU assessmentsIntensive care unitMechanical ventilationMedian durationICU stayBenzodiazepine doseSedation protocolPatient assessmentBaseline cohortTrauma-surgical intensive care unitConfusion Assessment Method-ICURichmond Agitation-Sedation Scale scorePrespecified secondary endpointSedation Scale scoreDays of deliriumImproved patient outcomesMultivariable linear regressionBenzodiazepine dosingBenzodiazepine exposureDelirium protocolHospital mortalityPneumonia ratesProtocol cohortRASS assessmentsImproved analgesia
2007
Is it now time to promote mixed enteral and parenteral nutrition for the critically ill patient?
Heidegger CP, Romand JA, Treggiari MM, Pichard C. Is it now time to promote mixed enteral and parenteral nutrition for the critically ill patient? Intensive Care Medicine 2007, 33: 963. PMID: 17468845, DOI: 10.1007/s00134-007-0654-7.Peer-Reviewed Original ResearchConceptsEnteral nutritionParenteral nutritionNutrition supportIll patientsNutritional supportCare outcomesSupplemental parenteral nutritionTimely nutrition supportLonger ICU stayIntensive care outcomesTight glycaemic controlStandard of careICU stayEnteral feedingGlycaemic controlICU patientsImproved survivalEnteral supportExcess mortalityGastrointestinal tractCurrent recommendationsNutrition deficitsProtein intakeOverall outcomeRecent FindingsAn