2023
Association of Early Dexmedetomidine Utilization With Clinical and Functional Outcomes Following Moderate-Severe Traumatic Brain Injury: A Transforming Clinical Research and Knowledge in Traumatic Brain Injury Study*
Liu S, Kelly-Hedrick M, Temkin N, Barber J, Komisarow J, Hatfield J, Ohnuma T, Manley G, Treggiari M, Colton K, Vavilala M, Grandhi R, Laskowitz D, Mathew J, Hernandez A, James M, Raghunathan K, Goldstein B, Markowitz A, Krishnamoorthy V, Investigators T. Association of Early Dexmedetomidine Utilization With Clinical and Functional Outcomes Following Moderate-Severe Traumatic Brain Injury: A Transforming Clinical Research and Knowledge in Traumatic Brain Injury Study*. Critical Care Medicine 2023, 52: 607-617. PMID: 37966330, PMCID: PMC10939970, DOI: 10.1097/ccm.0000000000006106.Peer-Reviewed Original ResearchModerate-severe traumatic brain injuryDisability Rating ScaleDexmedetomidine exposureHours of admissionTraumatic brain injuryFunctional outcomeHospital stayMechanical ventilationBrain injuryICP monitoringGlasgow Outcome Scale-ExtendedLevel 1 trauma centerClinical researchSevere traumatic brain injuryTraumatic Brain Injury (CENTER-TBI) studyFollowing secondary outcomesRetrospective cohort studySecond-line agentsPropensity-weighted modelsBrain Injury StudyLower DRS scoresEarly dexmedetomidineHospital mortalitySedation choiceUnexposed patients
2012
Mortality and long-term functional outcome associated with intracranial pressure after traumatic brain injury
Badri S, Chen J, Barber J, Temkin NR, Dikmen SS, Chesnut RM, Deem S, Yanez ND, Treggiari MM. Mortality and long-term functional outcome associated with intracranial pressure after traumatic brain injury. Intensive Care Medicine 2012, 38: 1800-1809. PMID: 23011528, DOI: 10.1007/s00134-012-2655-4.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryAverage intracranial pressureIntracranial pressureFunctional statusTBI patientsBrain injuryNeuropsychological functioningAbbreviated Injury Scale headLong-term functional outcomeSevere traumatic brain injuryAdult TBI patientsInjury scale headGlasgow Coma ScoreSevere TBI patientsPrimary endpointComa ScoreComposite endpointIndependent predictorsFunctional outcomeOdds ratioMultivariable regressionNeuropsychological outcomesNeuropsychological testingPatientsNeuropsychological function