2022
Pharmacokinetics and Tolerability of Intraperitoneal Chloroprocaine After Fetal Extraction in Women Undergoing Cesarean Delivery
Togioka BM, Zarnegarnia Y, Bleyle LA, Koop D, Brookfield K, Yanez ND, Treggiari MM. Pharmacokinetics and Tolerability of Intraperitoneal Chloroprocaine After Fetal Extraction in Women Undergoing Cesarean Delivery. Anesthesia & Analgesia 2022, 135: 777-786. PMID: 35544759, DOI: 10.1213/ane.0000000000006064.Peer-Reviewed Original ResearchConceptsLocal anesthetic systemic toxicityPeak plasma concentrationCesarean deliveryPlasma concentrationsSystemic toxicityIntraperitoneal administrationFetal extractionMultiple-dose escalation studyPatient drug exposureMaternal blood samplesMaximum plasma concentrationRoute of administrationYears of ageClinical tolerabilityEscalation studySpinal anesthesiaUterine closureNeuraxial anesthesiaClinical symptomsDrug exposureClinical signsWomen 18Prospective assessmentBlood samplesPharmacokinetic profile
2004
Transpulmonary lactate gradient after hypothermic cardiopulmonary bypass
Bendjelid K, Treggiari MM, Romand JA. Transpulmonary lactate gradient after hypothermic cardiopulmonary bypass. Intensive Care Medicine 2004, 30: 817-821. PMID: 14985958, DOI: 10.1007/s00134-004-2179-7.Peer-Reviewed Original ResearchConceptsCardiopulmonary bypass durationAcute lung injuryPulmonary lactate releaseCardiopulmonary bypassBypass durationLactate releaseAortic cross-clamping timeEffects of CPBPost-cardiac surgery patientsCross-clamping timePulmonary artery catheterVenous blood samplesHypothermic cardiopulmonary bypassConclusionThe present studyPulmonary releaseCardiac indexArtery catheterLung injurySurgery patientsSurgical ICUMechanical ventilationCardiac outputUniversity HospitalBlood samplesPatients