1998
Reaction of nitric oxide with superoxide inhibits basolateral K+ channels in the rat CCD
Lu M, Wang W. Reaction of nitric oxide with superoxide inhibits basolateral K+ channels in the rat CCD. American Journal Of Physiology 1998, 275: c309-c316. PMID: 9688863, DOI: 10.1152/ajpcell.1998.275.1.c309.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MembraneCyclic GMPDitiocarbIn Vitro TechniquesKidney CortexKidney Tubules, CollectingMembrane PotentialsNitratesNitric OxideNitroprussidePatch-Clamp TechniquesPenicillaminePotassium ChannelsPotassium Channels, Calcium-ActivatedPyrogallolRatsRats, Sprague-DawleySmall-Conductance Calcium-Activated Potassium ChannelsS-Nitroso-N-AcetylpenicillamineSuperoxidesConceptsNitric oxideInhibitory effectChannel activityPatch-clamp techniqueCGMP-dependent pathwayMicroM SNAPRat CCDCGMP productionNO donorRat kidneyControl valuesMM TironIntracellular scavengerExogenous cGMPSuperoxide dismutaseOpen probabilityControl conditionHigh concentrationsDiethyldithiocarbamic acidDonorsKidney
1996
Nitric oxide regulates the low-conductance K+ channel in basolateral membrane of cortical collecting duct
Lu M, Wang W. Nitric oxide regulates the low-conductance K+ channel in basolateral membrane of cortical collecting duct. American Journal Of Physiology 1996, 270: c1336-c1342. PMID: 8967433, DOI: 10.1152/ajpcell.1996.270.5.c1336.Peer-Reviewed Original ResearchConceptsNitric oxide synthaseCGMP-dependent pathwayL-NAMEL-NIOChannel activityL-arginine methyl esterExogenous nitric oxide donorOutward slope conductanceSlope conductanceNitric oxide donorPatch-clamp techniqueCell-attached patchesInward slope conductanceOxide synthaseBasolateral membraneSodium nitroprussideOxide donorRat kidneyNitric oxideIntermediate conductanceInhibitory effectEffect of NOTetraethylammonium chlorideMicroM NCyclic monophosphate