1997
Phospholipase A2 is involved in mediating the effect of extracellular Ca2+ on apical K+ channels in rat TAL
Wang W, Lu M, Balazy M, Hebert S. Phospholipase A2 is involved in mediating the effect of extracellular Ca2+ on apical K+ channels in rat TAL. American Journal Of Physiology 1997, 273: f421-f429. PMID: 9321915, DOI: 10.1152/ajprenal.1997.273.3.f421.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumEstrenesFluorescent DyesFura-2GadoliniumHydroxyeicosatetraenoic AcidsKidney CortexKidney MedullaKineticsLoop of HenleMembrane PotentialsPatch-Clamp TechniquesPhosphodiesterase InhibitorsPhospholipases APhospholipases A2Potassium ChannelsPyrrolidinonesRatsRats, Sprague-DawleyTime FactorsConceptsThick ascending limbMicroM Gd3Phospholipase A2Extracellular Ca2Rat thick ascending limbAddition of thapsigarginEffects of stimulationInflux of Ca2Channel activityPatch-clamp techniquePhospholipase CCell-attached patchesMicroM gadoliniumFura-2Ascending limbFluorescent sodium indicatorIntracellular Ca2Rat kidneyInhibitory effectAcetoxymethyl esterInhibitionStimulationCa2Signaling mechanismSodium indicator
1996
Effect of angiotensin II on the apical K+ channel in the thick ascending limb of the rat kidney.
Lu M, Zhu Y, Balazy M, Reddy K, Falck J, Wang W. Effect of angiotensin II on the apical K+ channel in the thick ascending limb of the rat kidney. The Journal Of General Physiology 1996, 108: 537-547. PMID: 8972391, PMCID: PMC2229337, DOI: 10.1085/jgp.108.6.537.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAnimalsCell MembraneCytochrome P-450 Enzyme InhibitorsDose-Response Relationship, DrugEnzyme InhibitorsFatty Acids, UnsaturatedHydroxyeicosatetraenoic AcidsIn Vitro TechniquesLoop of HenleNaphthalenesNG-Nitroarginine Methyl EsterPatch-Clamp TechniquesPenicillaminePotassium Channel BlockersPotassium ChannelsRatsRats, Sprague-DawleyS-Nitroso-N-AcetylpenicillamineSodiumConceptsEffect of AIIThick ascending limbAngiotensin IIControl valuesInhibitory effectChannel activityAscending limbRat kidneyL-arginine methyl esterArachidonic acidStimulatory effectExogenous nitric oxide donorNM angiotensin IIMicroM NG-nitroNitric oxide synthaseMajor AA metaboliteNitric oxide donorMicroM calphostin CPatch-clamp techniqueP450-dependent pathwayL-NAMENG-nitroCell-attached patchesOxide synthaseP450 metabolites
1995
Effect of arachidonic acid on activity of the apical K+ channel in the thick ascending limb of the rat kidney.
Wang W, Lu M. Effect of arachidonic acid on activity of the apical K+ channel in the thick ascending limb of the rat kidney. The Journal Of General Physiology 1995, 106: 727-743. PMID: 8576704, PMCID: PMC2229275, DOI: 10.1085/jgp.106.4.727.Peer-Reviewed Original ResearchConceptsThick ascending limbEffect of AAMicroM arachidonic acidArachidonic acidInhibitory effectAscending limbChannel activityAction of AARat kidneyMedullary thick ascending limbCytochrome P450 metabolic pathwayCytochrome P450 metabolitesPatch-clamp techniqueCell-attached patchesMicroM indomethacinP450 metabolitesMicroM linoleic acidStimulatory effectMetabolic pathwaysMain metaboliteKidneySpecific inhibitorLinoleic acidPredominant typeLimb