2018
Lipopolysaccharide stimulates BK channel activity in bladder umbrella cells
Lu M, Li JR, Alvarez-Lugo L, Li Y, Yu S, Li X, Shi B, Chai TC. Lipopolysaccharide stimulates BK channel activity in bladder umbrella cells. American Journal Of Physiology - Cell Physiology 2018, 314: c643-c653. PMID: 29466671, DOI: 10.1152/ajpcell.00339.2017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCyclic AMP-Dependent Protein KinasesFemaleLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsLipopolysaccharide ReceptorsLipopolysaccharidesLymphocyte Antigen 96Membrane PotentialsMice, Inbred C57BLPatch-Clamp TechniquesPotassiumSignal TransductionToll-Like Receptor 4Urinary BladderUrinary Tract InfectionsUrotheliumConceptsBK channel activityBK channelsChannel activityUmbrella cellsUrinary tract infectionFemale C57BL6 micePotassium channel inhibitorsUropathogenic Escherichia coliProtein kinase ATract infectionsLPS effectsC57BL6 miceBladder urotheliumLamina propriaMin of exposureChannel inhibitorsBacterial infectionsLPS receptorUrothelial tissuesUrothelial cellsUrotheliumLipopolysaccharidePotassium channelsRT-PCRPKA blocker
2015
Mucosal signaling in the bladder
Chai TC, Russo A, Yu S, Lu M. Mucosal signaling in the bladder. Autonomic Neuroscience 2015, 200: 49-56. PMID: 26422993, DOI: 10.1016/j.autneu.2015.08.009.Peer-Reviewed Original ResearchConceptsElectrical field stimulationLamina propriaNerve fibersMuscularis mucosaeNeural activitySpontaneous electrical activityNon-neuronal cellsSmooth muscle fibersMucosal contractionEfferent nervesBladder disordersAutonomic nervesAfferent activityBladder mucosaField stimulationHigh prevalenceMucosaStretch stimulusUrothelial cellsNerveElectrical activityMuscle fibersLuminal sideUrotheliumMultilayered urothelium