Bladder urothelial BK channel activity is a critical mediator for innate immune response in urinary tract infection pathogenesis
Yeh J, Lu M, Alvarez-Lugo L, Chai TC. Bladder urothelial BK channel activity is a critical mediator for innate immune response in urinary tract infection pathogenesis. American Journal Of Physiology. Renal Physiology 2019, 316: f617-f623. PMID: 30648906, DOI: 10.1152/ajprenal.00554.2018.Peer-Reviewed Original ResearchConceptsUrinary tract infectionInnate immune responseImmune responseBK channel activityUrinary tract infection pathogenesisChannel activityFemale C57BL/6 miceInflammatory protein-2Voltage-gated potassium channelsUropathogenic Escherichia coliInhibitor iberiotoxinUPEC exposureUTI pathogenesisInflammatory biomarkersTract infectionsC57BL/6 miceIL-6Urinary biomarkersUrinary changesBiomarker levelsInfection pathogenesisUrine specimensProtein 10LPS inoculationSame biomarkers