1997
Nitric oxide-induced hyperpolarization stimulates low-conductance Na+ channel of rat CCD
Lu M, Giebisch G, Wang W. Nitric oxide-induced hyperpolarization stimulates low-conductance Na+ channel of rat CCD. American Journal Of Physiology 1997, 272: f498-f504. PMID: 9140051, DOI: 10.1152/ajprenal.1997.272.4.f498.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCyclic GMPElectric ConductivityKidney CortexKidney Tubules, CollectingKineticsMembrane PotentialsModels, BiologicalNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide SynthasePatch-Clamp TechniquesPenicillamineRatsRats, Sprague-DawleyS-Nitroso-N-AcetylpenicillamineSodium ChannelsTime FactorsConceptsL-NAMESodium nitroprussideNitric oxideNitro-L-arginine methyl esterL-NAME-induced decreaseAction of NOL-NAME resultsS-nitroso-N-acetyl penicillamineEffect of NOEffect of SNAPWhole-cell recordingsMicroM sodium nitroprussidePatch-clamp techniqueExogenous NO donorD-NAMENO synthaseMicroM amilorideRat CCDCell recordingsNO donorControl valuesStimulatory effectIndirect actionDependent pathwayHyperpolarization
1996
Nitric oxide regulates the low-conductance K+ channel in basolateral membrane of cortical collecting duct
Lu M, Wang W. Nitric oxide regulates the low-conductance K+ channel in basolateral membrane of cortical collecting duct. American Journal Of Physiology 1996, 270: c1336-c1342. PMID: 8967433, DOI: 10.1152/ajpcell.1996.270.5.c1336.Peer-Reviewed Original ResearchConceptsNitric oxide synthaseCGMP-dependent pathwayL-NAMEL-NIOChannel activityL-arginine methyl esterExogenous nitric oxide donorOutward slope conductanceSlope conductanceNitric oxide donorPatch-clamp techniqueCell-attached patchesInward slope conductanceOxide synthaseBasolateral membraneSodium nitroprussideOxide donorRat kidneyNitric oxideIntermediate conductanceInhibitory effectEffect of NOTetraethylammonium chlorideMicroM NCyclic monophosphate