2003
ROMK is required for expression of the 70-pS K channel in the thick ascending limb
Lu M, Wang T, Yan Q, Wang W, Giebisch G, Hebert SC. ROMK is required for expression of the 70-pS K channel in the thick ascending limb. American Journal Of Physiology. Renal Physiology 2003, 286: f490-f495. PMID: 14600033, DOI: 10.1152/ajprenal.00305.2003.Peer-Reviewed Original ResearchConceptsThick ascending limbBartter's syndromeK dietK channelsAscending limbChannel activityApical K channelsFunctional expressionHypokalemic alkalosisTAL cellsNull miceSK activityHeterozygous miceHeterogeneous disorderMicePotassium recyclingROMKFunction mutationsSyndromeCritical subunitApical conductanceSalt absorptionLimbDietExpression
1995
Effect of arachidonic acid on activity of the apical K+ channel in the thick ascending limb of the rat kidney.
Wang W, Lu M. Effect of arachidonic acid on activity of the apical K+ channel in the thick ascending limb of the rat kidney. The Journal Of General Physiology 1995, 106: 727-743. PMID: 8576704, PMCID: PMC2229275, DOI: 10.1085/jgp.106.4.727.Peer-Reviewed Original ResearchConceptsThick ascending limbEffect of AAMicroM arachidonic acidArachidonic acidInhibitory effectAscending limbChannel activityAction of AARat kidneyMedullary thick ascending limbCytochrome P450 metabolic pathwayCytochrome P450 metabolitesPatch-clamp techniqueCell-attached patchesMicroM indomethacinP450 metabolitesMicroM linoleic acidStimulatory effectMetabolic pathwaysMain metaboliteKidneySpecific inhibitorLinoleic acidPredominant typeLimb