Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1
Wei D, Tao R, Zhang Y, White M, Dong X. Feedback regulation of hepatic gluconeogenesis through modulation of SHP/Nr0b2 gene expression by Sirt1 and FoxO1. AJP Endocrinology And Metabolism 2010, 300: e312-e320. PMID: 21081708, PMCID: PMC3043623, DOI: 10.1152/ajpendo.00524.2010.Peer-Reviewed Original ResearchConceptsGene expressionForkhead transcription factor FOXO1PDK4 gene expressionWild-type backgroundChromatin immunoprecipitation analysisProtein deacetylase SIRT1Transcription factor FOXO1Orphan nuclear receptorHepatic gluconeogenesisCatalytic domainDNA sequencesSmall heterodimer partnerImmunoprecipitation analysisInactivation of SIRT1Physiological processesDeacetylase SIRT1Luciferase reporterInsulin receptorFeedback regulationNuclear receptorsFOXO1Heterodimer partnerGenesHepatic insulin receptorSystemic glucose tolerance