2015
Propagation of Homeostatic Sleep Signals by Segregated Synaptic Microcircuits of the Drosophila Mushroom Body
Sitaraman D, Aso Y, Jin X, Chen N, Felix M, Rubin GM, Nitabach MN. Propagation of Homeostatic Sleep Signals by Segregated Synaptic Microcircuits of the Drosophila Mushroom Body. Current Biology 2015, 25: 2915-2927. PMID: 26455303, PMCID: PMC4654684, DOI: 10.1016/j.cub.2015.09.017.Peer-Reviewed Original ResearchConceptsSynaptic microcircuitsDrosophila mushroom bodyKenyon cellsMushroom bodiesMB neuronsControl of sleepHomeostatic rebound sleepHomeostatic sleep regulationIncreases sleepRebound sleepSleep regulationMBONsSleep deprivationNeuron classesSleepSleep informationMemory centerSpecific functional connectionsFunctional connectionsNeuronsPhysiological approachDifferent populationsMicrocircuits
2013
O-GlcNAc Signaling Entrains the Circadian Clock by Inhibiting BMAL1/CLOCK Ubiquitination
Li MD, Ruan HB, Hughes ME, Lee JS, Singh JP, Jones SP, Nitabach MN, Yang X. O-GlcNAc Signaling Entrains the Circadian Clock by Inhibiting BMAL1/CLOCK Ubiquitination. Cell Metabolism 2013, 17: 303-310. PMID: 23395176, PMCID: PMC3647362, DOI: 10.1016/j.cmet.2012.12.015.Peer-Reviewed Original ResearchConceptsCircadian clockProtein modificationNutrient-sensing pathwaysO-GlcNAc signalingHexosamine biosynthesis pathwayCovalent protein modificationBiosynthesis pathwayGlcNAc transferaseNutritional signalsClock oscillationsO-GlcNAcylationAberrant circadian rhythmsClock targetsOGT expressionCircadian oscillationsUbiquitinationN-acetylglucosamineNutrient fluxesMetabolic oscillationsBMAL1GenesPathwayCircadian rhythmKey mechanismClock