2016
Presynaptic GABA Receptors Mediate Temporal Contrast Enhancement in Drosophila Olfactory Sensory Neurons and Modulate Odor-Driven Behavioral Kinetics
Raccuglia D, McCurdy LY, Demir M, Gorur-Shandilya S, Kunst M, Emonet T, Nitabach MN. Presynaptic GABA Receptors Mediate Temporal Contrast Enhancement in Drosophila Olfactory Sensory Neurons and Modulate Odor-Driven Behavioral Kinetics. ENeuro 2016, 3: eneuro.0080-16.2016. PMID: 27588305, PMCID: PMC4994068, DOI: 10.1523/eneuro.0080-16.2016.Peer-Reviewed Original ResearchConceptsOlfactory sensory neuronsPeripheral responsesGABA receptorsSensory neuronsContrast enhancementOSN axon terminalsInhibitory GABA receptorsPresynaptic GABAAxon terminalsDrosophila olfactory sensory neuronsPresynaptic terminalsNervous systemAuditory stimuliTemporal edgeOlfactory systemTime courseNeuronsInnate behavioral responsesReceptorsOptical electrophysiologyTemporal contrast enhancementBehavioral responsesLateral inhibitionResponseGABA
2011
Synchronized Bilateral Synaptic Inputs to Drosophila melanogaster Neuropeptidergic Rest/Arousal Neurons
McCarthy EV, Wu Y, deCarvalho T, Brandt C, Cao G, Nitabach MN. Synchronized Bilateral Synaptic Inputs to Drosophila melanogaster Neuropeptidergic Rest/Arousal Neurons. Journal Of Neuroscience 2011, 31: 8181-8193. PMID: 21632940, PMCID: PMC3125135, DOI: 10.1523/jneurosci.2017-10.2011.Peer-Reviewed Original ResearchConceptsSynaptic inputsWhole-cell patch-clamp recordingsNicotinic acetylcholine receptor antagonistDual whole-cell patch-clamp recordingsAcetylcholine receptor antagonistNicotinic ACh receptorsSynchronous synaptic inputPatch-clamp recordingsWake-promoting neuronsLarge ventrolateral neuronsArousal neuronsSodium blockersGABAergic inputsCholinergic inputReceptor antagonistSynaptic circuitryACh receptorsNeurotransmitter receptorsBilateral inputSynaptic connectionsΑ-bungarotoxinVentrolateral neuronsContralateral pairsFiring patternsNeurons