2008
A Novel Form of Human Mendelian Hypertension Featuring Nonglucocorticoid-Remediable Aldosteronism
Geller DS, Zhang J, Wisgerhof MV, Shackleton C, Kashgarian M, Lifton RP. A Novel Form of Human Mendelian Hypertension Featuring Nonglucocorticoid-Remediable Aldosteronism. The Journal Of Clinical Endocrinology & Metabolism 2008, 93: 3117-3123. PMID: 18505761, PMCID: PMC2515083, DOI: 10.1210/jc.2008-0594.Peer-Reviewed Original ResearchConceptsGlucocorticoid-remediable aldosteronismAdrenal fasciculataAdministration of dexamethasoneAdrenal steroid productionAdrenal steroid biosynthesisNew familial formAge 7 yrSecondary hypertensionBilateral adrenalectomyMost patientsPrimary aldosteronismAdrenal weightClinical syndromeAdrenal glandCortisol secretionLeading causeAldosteronismHypertensionMedical treatmentAldosterone synthaseSteroid productionAutosomal dominant formCellular hypertrophyCortical compartmentFamilial forms
1987
Response of collecting tubule cells to aldosterone and potassium loading
Kashgarian M, Ardito T, Hirsch D, Hayslett J. Response of collecting tubule cells to aldosterone and potassium loading. American Journal Of Physiology 1987, 253: f8-f14. PMID: 3605352, DOI: 10.1152/ajprenal.1987.253.1.f8.Peer-Reviewed Original ResearchMeSH KeywordsAldosteroneAnimalsHyperaldosteronismKidney TubulesKidney Tubules, CollectingMalePotassiumRatsRats, Inbred StrainsSurface PropertiesConceptsInitial collecting tubuleCortical collecting tubuleBasolateral membrane surfaceCollecting tubuleChronic potassium loadingElevated levelsDuct structuresPotassium loadingSite of actionPlasma levelsRat modelOuter stripeInner stripeTubule cellsNormal physiological levelsControl valuesAldoMorphometric studyAldosteronePhysiological levelsDuct systemTubulesConcomitant changesDuct
1970
A Study of the Renin-Angiotensin System in Patients with Severe Chronic Renal Insufficiency
Kotchen T, Knight E, Kashgarian M, Mulrow P. A Study of the Renin-Angiotensin System in Patients with Severe Chronic Renal Insufficiency. Nephron 1970, 7: 317-330. PMID: 4316656, DOI: 10.1159/000179832.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIBiopsyBody WeightHumansHyperaldosteronismHypertension, MalignantKidneyKidney Failure, ChronicRenal DialysisReninUremiaConceptsRenin activitySevere chronic renal insufficiencyChronic dialysis programRenin substrate levelsChronic renal insufficiencyPlasma renin activityMean arterial pressureRenin-angiotensin systemNormal plasma levelsMalignant hypertensionRenal insufficiencyRenin levelsOnly patientsArterial pressureBlood pressureUremic patientsDialysis programPlasma levelsUremic plasmaAutopsy specimensJG cellsBowie stainPatientsReninDialysis