1984
Beneficial effect of thyroxin on recovery from toxic acute renal failure
Siegel N, Gaudio K, Katz L, Reilly H, Ardito T, Hendler F, Kashgarian M. Beneficial effect of thyroxin on recovery from toxic acute renal failure. Kidney International 1984, 25: 906-911. PMID: 6471672, DOI: 10.1038/ki.1984.108.Peer-Reviewed Original ResearchConceptsToxic acute renal failureAcute renal failureNormal salineRenal failureBeneficial effectsInjected ratsOnly normal salineT4-treated ratsEffect of thyroxinNonspecific systemic effectsT4-treated animalsRenal insultHemodynamic effectsRenal functionRenal injuryControl ratsGlomerular functionUrine flowSimilar doseSystemic effectsEnhanced recoveryPrompt recoveryKidney preparationRatsFENa
1980
ISCHEMIC ACUTE RENAL FAILURE: ENHANCED RECOVERY OF SUPERFICIAL NEPHRON FUNCTION BY ATP-MGCL2
Gaudio K, Sieqel N, Chaudry I, Kashgarian M. ISCHEMIC ACUTE RENAL FAILURE: ENHANCED RECOVERY OF SUPERFICIAL NEPHRON FUNCTION BY ATP-MGCL2. Pediatric Research 1980, 14: 1017-1017. DOI: 10.1203/00006450-198008000-00261.Peer-Reviewed Original ResearchSuperficial single nephron GFRWhole kidney GFRIntratubular obstructionATP-MgCl2Superficial nephronsHemodynamic factorsBilateral renal artery occlusionCortical blood flow distributionTotal renal blood flowControl valuesIschemic renal insultRenal artery occlusionRenal blood flowSingle nephron GFRBlood flow distributionProximal tubular pressureRenal insultArtery occlusionNephron GFREnhancement of recoveryKidney GFRBlood flowEnhanced recoveryNormal valuesGFREnhanced recovery from acute renal failure by the postischemic infusion of adenine nucleotides and magnesium chloride in rats
Siegel N, Glazier W, Chaudry I, Gaudio K, Lytton B, Baue A, Kashgarian M. Enhanced recovery from acute renal failure by the postischemic infusion of adenine nucleotides and magnesium chloride in rats. Kidney International 1980, 17: 338-349. PMID: 7401453, DOI: 10.1038/ki.1980.39.Peer-Reviewed Original ResearchConceptsAcute renal failureRenal injuryRenal failureAcute renal injuryIschemic renal injuryAdenine nucleotidesFocal cellular necrosisElevated FENaRenal insultIschemic kidneyIschemic periodTubular functionAcute insultNonischemic kidneysPostischemic infusionFunctional impairmentTubular cellsDegree of improvementCellular necrosisRatsInfusionCINUltrastructural changesUltrastructural studyFENa