2015
Periosteal PTHrP Regulates Cortical Bone Remodeling During Fracture Healing
Wang M, Nasiri AR, Broadus AE, Tommasini SM. Periosteal PTHrP Regulates Cortical Bone Remodeling During Fracture Healing. Bone 2015, 81: 104-111. PMID: 26164475, PMCID: PMC4641003, DOI: 10.1016/j.bone.2015.07.008.Peer-Reviewed Original ResearchConceptsFracture healingPTHrP expressionCKO miceCortical bone surfaceFracture repairTibial fracture surgeryRole of PTHrPHormone-related proteinTibial fracture modelCartilaginous callus formationConditional knockout miceBone surfaceCortical bone remodelingType I receptorCD1 controlsFracture surgeryCD1 miceKnockout miceInitial genetic evidencePTHrPOsteoblastic activityBone remodelingMiceBone mineralizationI receptor
2013
MMP13 is a critical target gene during the progression of osteoarthritis
Wang M, Sampson ER, Jin H, Li J, Ke QH, Im HJ, Chen D. MMP13 is a critical target gene during the progression of osteoarthritis. Arthritis Research & Therapy 2013, 15: r5. PMID: 23298463, PMCID: PMC3672752, DOI: 10.1186/ar4133.Peer-Reviewed Original ResearchConceptsMeniscal-ligamentous injuryOA progressionControl miceMMP13 activityType II collagenTUNEL stainingCre-negative control miceChondrocyte apoptosisEffective disease-modifying treatmentTerminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) stainingTransferase dUTP nick end labeling stainingDUTP nick end labeling stainingRole of MMP13Nick end labeling stainingArticular cartilage lossCartilage gradingDisease-modifying treatmentsProgression of osteoarthritisWild-type miceDegenerative joint diseaseDevelopment of OAResults of immunohistochemistryEnd labeling stainingCre-negative miceArticular cartilage degeneration