Uncommon Protein-Coding Variants Associated With Suicide Attempt in a Diverse Sample of U.S. Army Soldiers
Wilkerson M, Hupalo D, Gray J, Zhang X, Wang J, Girgenti M, Alba C, Sukumar G, Lott N, Naifeh J, Aliaga P, Kessler R, Turner C, Pollard H, Dalgard C, Ursano R, Stein M. Uncommon Protein-Coding Variants Associated With Suicide Attempt in a Diverse Sample of U.S. Army Soldiers. Biological Psychiatry 2023, 96: 15-25. PMID: 38141912, DOI: 10.1016/j.biopsych.2023.12.008.Peer-Reviewed Original ResearchSingle variant analysisProtein-coding variantsVariant analysisCommon genetic variantsWhole-genome sequencingMost genesWhole genomeGenome sequencingSignificant genesMolecular characterizationGenesGenetic variantsAncestry groupsGenetic risk factorsExomeYWHAERecent studiesVariantsATAD3ARC3H2EP400GenomeRcn2SGMS1STARD9STRESS IN A DISH: MODELING THE IMPACT OF COMMON GENETIC VARIATION ON STRESS RESPONSE IN HIPSC-DERIVED NEURONS IN PTSD
Seah C, Signer R, Young H, Kozik E, Rusielewicz T, Bader H, Xu C, de Pins A, Breen M, Paull D, Yehuda R, Girgenti M, Brennand K, Huckins L. STRESS IN A DISH: MODELING THE IMPACT OF COMMON GENETIC VARIATION ON STRESS RESPONSE IN HIPSC-DERIVED NEURONS IN PTSD. European Neuropsychopharmacology 2023, 75: s40. DOI: 10.1016/j.euroneuro.2023.08.081.Peer-Reviewed Original ResearchCommon genetic variationGenetic variationStress responseCell typesEQTL associationsTranscriptional stress responseGenomic risk lociTissue-specific mannerChIP-seq datasetsCell type deconvolutionCommon genetic variantsPost-mortem brainsGene expression signaturesHiPSC-derived neuronsTranscription factorsSuch lociCatalog genesRisk lociGenetic studiesExpression signaturesGenetic variantsRegulatory activityGenesEQTLsMechanistic understanding