2020
Exploring the impact of trauma type and extent of exposure on posttraumatic alterations in 5-HT1A expression
Lewis M, Jones R, Davis M. Exploring the impact of trauma type and extent of exposure on posttraumatic alterations in 5-HT1A expression. Translational Psychiatry 2020, 10: 237. PMID: 32678079, PMCID: PMC7366706, DOI: 10.1038/s41398-020-00915-1.Peer-Reviewed Original ResearchConceptsTrauma typesTrauma exposureImpact of trauma typeExposure to potentially traumatic eventsSerotonin 1 A receptorExpression of 5-HT1AImpact of trauma exposureTrauma-exposed individualsRegulating serotonin releasePotentially traumatic eventsG protein-coupled serotonin receptorsImpact of traumaNeurobiological impactNeurobiological effectsHTR1A genePsychiatric syndromesEmotional behaviorPsychiatric symptomsStress respondingSerotonin receptorsTraumatic eventsSerotonin releaseExtent of exposureHuman literatureTrauma-induced changesPTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies
Bhatt S, Hillmer AT, Girgenti MJ, Rusowicz A, Kapinos M, Nabulsi N, Huang Y, Matuskey D, Angarita GA, Esterlis I, Davis MT, Southwick SM, Friedman MJ, Duman R, Carson R, Krystal J, Pietrzak R, Cosgrove K. PTSD is associated with neuroimmune suppression: evidence from PET imaging and postmortem transcriptomic studies. Nature Communications 2020, 11: 2360. PMID: 32398677, PMCID: PMC7217830, DOI: 10.1038/s41467-020-15930-5.Peer-Reviewed Original ResearchMeSH KeywordsAcetamidesAdaptor Proteins, Signal TransducingAdultBrainCase-Control StudiesFemaleGene Expression ProfilingHealthy VolunteersHumansMaleMicrogliaMiddle AgedPositron-Emission TomographyPyridinesRadiopharmaceuticalsReceptors, GABAReceptors, Tumor Necrosis Factor, Member 14Sex FactorsStress Disorders, Post-TraumaticYoung AdultConceptsPosttraumatic stress disorderPeripheral immune activationImmune activationHigher C-reactive protein levelsC-reactive protein levelsTSPO availabilityTranslocator proteinBrain microglial activationTomography brain imagingStress-related pathophysiologyPositron emission tomography (PET) brain imagingNeuroimmune activationMicroglial activationPTSD symptom severityImmunologic regulationPostmortem studiesPTSD subgroupHealthy individualsSymptom severityTrauma exposurePTSD groupStress disorderLower relative expressionBrain imagingPET imaging
2017
A psychometric evaluation of the Posttraumatic Cognitions Inventory with Veterans seeking treatment following military trauma exposure
Sexton MB, Davis MT, Bennett DC, Morris DH, Rauch SAM. A psychometric evaluation of the Posttraumatic Cognitions Inventory with Veterans seeking treatment following military trauma exposure. Journal Of Affective Disorders 2017, 226: 232-238. PMID: 29017066, DOI: 10.1016/j.jad.2017.09.048.Peer-Reviewed Original ResearchConceptsPosttraumatic Cognitions InventoryMilitary sexual traumaPosttraumatic stress disorderTrauma-related beliefsMilitary trauma exposureTrauma-focused treatmentTrauma exposureFactor modelTrauma typesStress disorderSexual traumaCritical constructsSalient relationshipsMilitary traumaStress exposurePsychometric evaluationFactor scoresSubscale scoresReliability validityConfirmatory analysisStandard assessmentVeteransInventoryValidityTrauma