1999
The effects of naltrexone maintenance on the response to yohimbine in healthy volunteers
Rosen M, Kosten T, Kreek M. The effects of naltrexone maintenance on the response to yohimbine in healthy volunteers. Biological Psychiatry 1999, 45: 1636-1645. PMID: 10376126, DOI: 10.1016/s0006-3223(98)00259-5.Peer-Reviewed Original ResearchConceptsWeeks of treatmentDrug effectsStrongest drug effectsOpioid antagonist naltrexoneActive naltrexoneNaltrexone treatmentNaltrexone maintenanceAntagonist naltrexoneHealthy subjectsHealthy volunteersWeek 1Week 2Cortisol levelsYohimbineWeek 5PlaceboPreclinical researchNaltrexoneAlters sensitivityEffect of pretreatmentWeeksAntagonistTreatmentStress responsivenessSubjects
1998
The effect of lamotrigine on naloxone-precipitated opiate withdrawal
Rosen M, Pearsall H, Kosten T. The effect of lamotrigine on naloxone-precipitated opiate withdrawal. Drug And Alcohol Dependence 1998, 52: 173-176. PMID: 9800147, DOI: 10.1016/s0376-8716(98)00057-x.Peer-Reviewed Original Research
1997
Effects of gamma-hydroxybutyric acid (GHB) in opioid-dependent patients
Rosen M, Pearsall H, Woods S, Kosten T. Effects of gamma-hydroxybutyric acid (GHB) in opioid-dependent patients. Journal Of Substance Use And Addiction Treatment 1997, 14: 149-154. PMID: 9258859, DOI: 10.1016/s0740-5472(96)00157-2.Peer-Reviewed Original ResearchDose Dependent Effects of Yohimbine on Methadone Maintained Patients
Hameedi F, Woods S, Rosen M, Pearsall H, Kosten T. Dose Dependent Effects of Yohimbine on Methadone Maintained Patients. The American Journal Of Drug And Alcohol Abuse 1997, 23: 327-333. PMID: 9143642, DOI: 10.3109/00952999709040950.Peer-Reviewed Original Research
1995
The Severity of Naloxone-Precipitated Opiate Withdrawal Is Attenuated by Felbamate, a Possible Glycine Antagonist
Kosten T, DeCaprio J, Rosen M. The Severity of Naloxone-Precipitated Opiate Withdrawal Is Attenuated by Felbamate, a Possible Glycine Antagonist. Neuropsychopharmacology 1995, 13: 323-333. PMID: 8747757, DOI: 10.1016/0893-133x(95)00065-l.Peer-Reviewed Original ResearchConceptsNaloxone-precipitated opiate withdrawalDose-related mannerOpiate withdrawalWithdrawal severityN-methyl-D-aspartate (NMDA) receptor systemPartial agonistOverall withdrawal severityGlycinergic agentsPenile groomingWithdrawal signsOpiate detoxificationHA-966NMDA antagonistsRostral medullaGlycine antagonistLow dosePotential treatmentPutative antagonistNMDA channelsClinical useReceptor systemAntagonistTeeth chatterD-cycloserineSeverityReliability of Sequential Naloxone Challenge Tests
Rosen M, McMahon T, Margolin A, Gill T, Woods S, Pearsall H, Kreek M, Kosten T. Reliability of Sequential Naloxone Challenge Tests. The American Journal Of Drug And Alcohol Abuse 1995, 21: 453-467. PMID: 8561097, DOI: 10.3109/00952999509002710.Peer-Reviewed Original Research