2024
Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study
Gleason C, Dowling N, Kara F, James T, Salazar H, Simo C, Harman S, Manson J, Hammers D, Naftolin F, Pal L, Miller V, Cedars M, Lobo R, Malek-Ahmadi M, Kantarci K. Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study. PLOS Medicine 2024, 21: e1004435. PMID: 39570992, PMCID: PMC11581397, DOI: 10.1371/journal.pmed.1004435.Peer-Reviewed Original ResearchConceptsOral conjugated equine estrogenLatent growth modelingLong-term cognitive effectsCognitive factor scoresCognitive benefitsCognitive performanceFactor scoresBaseline cognitionFollow-upClinical trialsEarly postmenopauseIn-person research visitsYears of follow-upRandomized to placeboMenopausal hormone therapyGlobal cognitive scoreNeuroimaging effectsCognitive measuresCognitive harmLongitudinal cohort studyCognitive changesCognitive slopesCognitive dataTest batteryCognitive functionChronicling menstrual cycle patterns across the reproductive lifespan with real-world data
Cunningham A, Pal L, Wickham A, Prentice C, Goddard F, Klepchukova A, Zhaunova L. Chronicling menstrual cycle patterns across the reproductive lifespan with real-world data. Scientific Reports 2024, 14: 10172. PMID: 38702411, PMCID: PMC11068910, DOI: 10.1038/s41598-024-60373-3.Peer-Reviewed Original ResearchAging and Adiposity—Focus on Biological Females at Midlife and Beyond
Rehman A, Lathief S, Charoenngam N, Pal L. Aging and Adiposity—Focus on Biological Females at Midlife and Beyond. International Journal Of Molecular Sciences 2024, 25: 2972. PMID: 38474226, PMCID: PMC10931752, DOI: 10.3390/ijms25052972.Peer-Reviewed Original Research
2023
Cardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial
Kantarci K, Tosakulwong N, Lesnick T, Kara F, Kendall-Thomas J, Kapoor E, Fields J, James T, Lobo R, Manson J, Pal L, Hammers D, Malek-Ahmadi M, Cedars M, Naftolin F, Santoro N, Miller V, Harman S, Dowling N, Gleason C. Cardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial. Menopause The Journal Of The North American Menopause Society 2023, 31: 10-17. PMID: 37989141, PMCID: PMC10756493, DOI: 10.1097/gme.0000000000002278.Peer-Reviewed Original ResearchConceptsKronos Early Estrogen Prevention StudyOral conjugated equine estrogenConjugated equine estrogensBetter cardiovascular healthHormone therapyEquine estrogensInsulin resistanceMenopausal womenCardiovascular healthClinical trialsHormone therapy trialsPerson clinic visitsDiastolic blood pressureHomeostasis model assessmentSelf-reported diabetesYears of onsetMultisite clinical trialLevels of glucoseMicronized progesteroneDiabetes medicationsStudy of participantsCardiometabolic effectsCardiometabolic outcomesClinic visitsBlood pressureExamining the association between urinary triclosan levels and menopausal status: results from the National Health and Nutrition Examination Survey, 2003 to 2016
Beroukhim G, Kayani J, Taylor H, Pal L. Examining the association between urinary triclosan levels and menopausal status: results from the National Health and Nutrition Examination Survey, 2003 to 2016. Menopause The Journal Of The North American Menopause Society 2023, 30: 906-912. PMID: 37625087, DOI: 10.1097/gme.0000000000002233.Peer-Reviewed Original ResearchConceptsMenopausal statusBody mass indexSmoking exposureMass indexNational HealthLinear regression analysisTCS levelsTriclosan levelsRetrospective cross-sectional studyMultivariable linear regression analysisReproductive health questionnaireUrinary triclosan levelsDuration of menopauseMultivariate linear regression analysisNutrition Examination SurveyCross-sectional studyYears of ageRegression analysisFemale participantsPostmenopausal statusPostmenopausal womenPremenopausal womenSurgical menopausePremature menopauseUrinary levelsTestosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome
Stone T, Yanes Cardozo L, Oluwatade T, Leone C, Burgos M, Okifo F, Pal L, Reckelhoff J, Stachenfeld N. Testosterone-associated blood pressure dysregulation in women with androgen excess polycystic ovary syndrome. AJP Heart And Circulatory Physiology 2023, 325: h232-h243. PMID: 37327000, PMCID: PMC10393337, DOI: 10.1152/ajpheart.00164.2023.Peer-Reviewed Original ResearchConceptsSympathetic nervous system activityBlood pressure dysregulationPolycystic ovary syndromeBody mass indexBaroreflex gainOvary syndromeBlood pressureObese insulin-resistant womenPolycystic ovary syndrome phenotypesRenin-angiotensin system activationSerum angiotensin-converting enzymeGonadotropin-releasing hormone antagonistLower sympathetic nervous system activityLower body negative pressureHeightened cardiovascular riskInsulin-resistant womenSystolic blood pressureBody negative pressureNervous system activityAngiotensin-converting enzymeIR womenCardiovascular riskSerum aldosteroneBaroreflex controlDiastolic BPVitamin D and infertility
Simpson S, Pal L. Vitamin D and infertility. Current Opinion In Obstetrics & Gynecology 2023, 35: 300-305. PMID: 37266579, DOI: 10.1097/gco.0000000000000887.Peer-Reviewed Original ResearchConceptsPolycystic ovarian syndromeVitamin DGynaecological disordersVitamin D serum levelsOvarian reserve parametersD serum levelsVitamin D deficiencyVitamin D statusDiminished ovarian reserveCommon gynaecological disorderReproductive health burdenHigher pregnancy rateD deficiencyD statusOvarian reserveOvarian syndromeInfertile womenSerum levelsUterine myomaMenstrual regularityEndometriosis patientsInsulin levelsUterine fibroidsHealth burdenPregnancy rateGenital tuberculosis, infertility and assisted reproduction
Mir N, Pal L. Genital tuberculosis, infertility and assisted reproduction. Current Opinion In Obstetrics & Gynecology 2023, 35: 263-269. PMID: 36912346, DOI: 10.1097/gco.0000000000000866.Peer-Reviewed Original ResearchConceptsGenital tuberculosisClinical presentationLife-threatening risksGenital TBFetal morbidityInfertile womenCouple infertilityAppropriate screeningTimely treatmentRisk populationsUntreated casesInfertilityAssisted reproductionReproductive technologiesUnique risksTuberculosisRiskPresentationMorbidityIVFEpidemiologyDiagnosisRecent literatureWomenImproving preparedness of emergency medicine residents in the management of postpartum hemorrhage: A randomized controlled study of two pedagogical approaches
Casper S, Kayani T, Galerneau F, Evans L, Pal L. Improving preparedness of emergency medicine residents in the management of postpartum hemorrhage: A randomized controlled study of two pedagogical approaches. International Journal Of Gynecology & Obstetrics 2023, 161: 1033-1039. PMID: 36527258, DOI: 10.1002/ijgo.14631.Peer-Reviewed Original ResearchConceptsPostpartum hemorrhagePPH managementEmergency medicine residentsManagement of PPHMedicine residentsPost-intervention assessmentT-testStudent's t-testClinical skills scoresBaseline testingImprovement of knowledgeParticipants' knowledgeDidactic lecturesHemorrhageEM residentsSimulation-based trainingDidactic sessionsForm of interventionEffects of covariatesAddition of simulationStructured curriculumNovel curriculumParticipants
2022
Follicle-stimulating hormone (and luteinizing hormone) in ovarian stimulation: Does the dose matter for cycle success?
Kuokkanen S, Pal L. Follicle-stimulating hormone (and luteinizing hormone) in ovarian stimulation: Does the dose matter for cycle success? Fertility And Sterility 2022, 119: 166-169. PMID: 36529184, DOI: 10.1016/j.fertnstert.2022.12.019.Peer-Reviewed Original ResearchAssociations between pituitary-ovarian hormones and cognition in recently menopausal women independent of type of hormone therapy
Kling J, Dowling N, Bimonte-Nelson H, Gleason C, Kantarci K, Stonnington C, Harman S, Naftolin F, Pal L, Cedars M, Manson J, James T, Brinton E, Miller V. Associations between pituitary-ovarian hormones and cognition in recently menopausal women independent of type of hormone therapy. Maturitas 2022, 167: 113-122. PMID: 36395695, PMCID: PMC10077876, DOI: 10.1016/j.maturitas.2022.10.002.Peer-Reviewed Original ResearchConceptsComplex attention tasksLatent growth curve modelsPoor cognitive performancePoorer global cognitionGrowth curve modelsAuditory attentionAttention taskCognitive factorsMental flexibilityVisual attentionExecutive functionCognitive domainsCognitive performanceCognitive trajectoriesGlobal cognitionPituitary-ovarian hormonesHormone therapyBaseline cognitionCognitionHormone levelsNeuropsychological testingMonth 18Menopausal womenEstrone levelsMonth 48
2021
Chronic endometritis: A prevalent yet poorly understood entity
Margulies SL, Flores V, Parkash V, Pal L. Chronic endometritis: A prevalent yet poorly understood entity. International Journal Of Gynecology & Obstetrics 2021, 158: 194-200. PMID: 34605024, DOI: 10.1002/ijgo.13962.Peer-Reviewed Original ResearchConceptsChronic endometritisExact testCross-sectional observational studyEvidence-based consensusObstetrician/gynecologistsFisher's exact testSpectrum of deficienciesGood clinical practiceChi-square testAnonymous electronic surveyClinical presentationUnderappreciated burdenTreatment strategiesObservational studyPrevalent conditionDiagnostic criteriaEndometritisClinical practiceClinical implicationsSquare testEndometritis diagnosisConfidence intervalsHealthcare systemPrevalent inconsistenciesElectronic survey
2020
The Diagnostic Criteria for Chronic Endometritis: A Survey of Pathologists
Margulies SL, Dhingra I, Flores V, Hecht JL, Fadare O, Pal L, Parkash V. The Diagnostic Criteria for Chronic Endometritis: A Survey of Pathologists. International Journal Of Gynecological Pathology 2020, 40: 556-562. PMID: 33323860, DOI: 10.1097/pgp.0000000000000737.Peer-Reviewed Original ResearchConceptsChronic endometritisDiagnostic criteriaSurvey of pathologistsManagement of patientsSingle plasma cellsAnonymous electronic surveyActive inflammationHormonal stagesGynecologic pathologistsPathologic diagnosisAcute endometritisPlasma cellsGestational endometriumSpecial stainsEndometritisSubstantial variabilityDiagnosisPathologistsTreatment implicationsGreater likelihoodElectronic surveyEndometriumEtiological understandingInflammationPatients
2017
Ovarian Sertoli-Leydig cell tumors: a single institution experience and review of the literature.
Gressel G, Buza N, Pal L. Ovarian Sertoli-Leydig cell tumors: a single institution experience and review of the literature. European Journal Of Gynaecological Oncology 2017, 38: 214-220. PMID: 29953783.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsChemotherapy, AdjuvantDisease-Free SurvivalFemaleHumansHyperandrogenismHysterectomyMiddle AgedNeoadjuvant TherapyNeoplasm GradingOvarian NeoplasmsOvariectomyPostmenopauseRetrospective StudiesSalpingectomySertoli-Leydig Cell TumorConceptsSertoli-Leydig cell tumorOvarian Sertoli-Leydig cell tumorPresent patient populationDisease-free survivalSingle institution experienceTertiary care institutionTime of diagnosisOnset of menopauseRisk of recurrenceSeries of casesAdjuvant chemotherapyMedian followPostmenopausal bleedingPostmenopausal patientsMedian ageMedian intervalClinical presentationDefinitive managementPathological findingsRetrospective reviewInstitution experiencePatient populationTreatment modalitiesCell tumorsTumor grade
2015
Management options and fertility‐preserving therapy for premenopausal endometrial hyperplasia and early‐stage endometrial cancer
Gressel GM, Parkash V, Pal L. Management options and fertility‐preserving therapy for premenopausal endometrial hyperplasia and early‐stage endometrial cancer. International Journal Of Gynecology & Obstetrics 2015, 131: 234-239. PMID: 26384790, DOI: 10.1016/j.ijgo.2015.06.031.Peer-Reviewed Original ResearchConceptsEarly-stage endometrial cancerEndometrial cancerEndometrial hyperplasiaFertility preservationFuture fertilityRisk factorsComplex atypical endometrial hyperplasiaEndometrial hyperplasia/cancerType 2 diabetes mellitusFertility-preserving therapyAtypical endometrial hyperplasiaPolycystic ovarian syndromeChronic anovulationLifestyle modificationPremenopausal womenConservative managementOvarian syndromeDefinitive managementDiabetes mellitusEndometrial pathologyGlycemic controlMetabolic syndromeDATA COLLECTIONCochrane DatabaseInsulin resistance
2008
Characterizing the reproductive hormone milieu in infertile women with diminished ovarian reserve
Pal L, Zhang K, Zeitlian G, Santoro N. Characterizing the reproductive hormone milieu in infertile women with diminished ovarian reserve. Fertility And Sterility 2008, 93: 1074-1079. PMID: 19100532, DOI: 10.1016/j.fertnstert.2008.10.069.Peer-Reviewed Original ResearchConceptsDiminished ovarian reserveReproductive hormone profilesOvarian reserveInfertile womenUrinary excretionMenstrual cycleHealthy controlsHormone profilesAge-comparable healthy controlsUrinary FSH levelsProspective observational studyEarly follicular phaseEntire menstrual cycleAge-comparable controlsMetabolites of estrogenFSH levelsHormone milieuInfertility practiceMenopause transitionUrine voidsFollicular phaseEstrone conjugatesFSH surgeObservational studyMAIN OUTCOMEDiminished ovarian reserve in a woman with a balanced 13;21 translocation
Kummer N, Martin JR, Pal L. Diminished ovarian reserve in a woman with a balanced 13;21 translocation. Fertility And Sterility 2008, 91: 931.e3-931.e5. PMID: 18829026, DOI: 10.1016/j.fertnstert.2008.07.1726.Peer-Reviewed Original ResearchConceptsOvarian reservePrimary infertilityDecreased ovarian reserveUniversity Teaching HospitalLaboratory evaluationBalanced autosomal translocationEndocrinologic evaluationConcomitant findingsEarly menopauseInfertility practiceUnknown etiologyCase reportCaucasian womenTeaching hospitalMAIN OUTCOMEFamilial historyReproductive endocrinologySemen analysisBalanced translocationInfertilityPossible roleDiagnosisWomenAutosomal translocationsKaryotype analysisGender “tailored” conceptions: should the option of embryo gender selection be available to infertile couples undergoing assisted reproductive technology?
Merhi Z, Pal L. Gender “tailored” conceptions: should the option of embryo gender selection be available to infertile couples undergoing assisted reproductive technology? Journal Of Medical Ethics 2008, 34: 590. PMID: 18667646, DOI: 10.1136/jme.2007.022079.Commentaries, Editorials and LettersLess is more: increased gonadotropin use for ovarian stimulation adversely influences clinical pregnancy and live birth after in vitro fertilization
Pal L, Jindal S, Witt BR, Santoro N. Less is more: increased gonadotropin use for ovarian stimulation adversely influences clinical pregnancy and live birth after in vitro fertilization. Fertility And Sterility 2008, 89: 1694-1701. PMID: 18440515, PMCID: PMC2601677, DOI: 10.1016/j.fertnstert.2007.05.055.Peer-Reviewed Original ResearchConceptsNondonor IVF cyclesClinical pregnancyCycle cancellationLive birthsGonadotropin useIVF cyclesSpontaneous miscarriageOvarian reserve statusOvarian hyperstimulation resultsHigh gonadotropinsOvarian stimulationFertilization cyclesIVF outcomesOocyte yieldWorse prognosisRetrospective studyIVF centerImproved outcomesAggressive approachMAIN OUTCOMEPregnancyIVFHigher likelihoodBirthOutcomes
2004
Postthaw blastomere survival is predictive of the success of frozen–Thawed embryo transfer cycles
Pal L, Kovacs P, Witt B, Jindal S, Santoro N, Barad D. Postthaw blastomere survival is predictive of the success of frozen–Thawed embryo transfer cycles. Fertility And Sterility 2004, 82: 821-826. PMID: 15482754, DOI: 10.1016/j.fertnstert.2004.02.136.Peer-Reviewed Original ResearchConceptsEmbryo transfer cyclesFET cyclesBlastomere survivalImplantation rateTransfer cyclesFrozen-thawed embryo transfer cyclesClinical pregnancy rateTertiary care facilitySerum P levelsClinical pregnancyHCG administrationInfertile womenRetrospective studyInverse associationIVF unitPregnancy rateMAIN OUTCOMECare facilitiesPregnancySurvivalOutcomesEmbryo survivalLower survivalHigher survivalAdministration