2024
Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study
Gleason C, Dowling N, Kara F, James T, Salazar H, Simo C, Harman S, Manson J, Hammers D, Naftolin F, Pal L, Miller V, Cedars M, Lobo R, Malek-Ahmadi M, Kantarci K. Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study. PLOS Medicine 2024, 21: e1004435. PMID: 39570992, PMCID: PMC11581397, DOI: 10.1371/journal.pmed.1004435.Peer-Reviewed Original ResearchConceptsOral conjugated equine estrogenLatent growth modelingLong-term cognitive effectsCognitive factor scoresCognitive benefitsCognitive performanceFactor scoresBaseline cognitionFollow-upClinical trialsEarly postmenopauseIn-person research visitsYears of follow-upRandomized to placeboMenopausal hormone therapyGlobal cognitive scoreNeuroimaging effectsCognitive measuresCognitive harmLongitudinal cohort studyCognitive changesCognitive slopesCognitive dataTest batteryCognitive function
2023
Cardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial
Kantarci K, Tosakulwong N, Lesnick T, Kara F, Kendall-Thomas J, Kapoor E, Fields J, James T, Lobo R, Manson J, Pal L, Hammers D, Malek-Ahmadi M, Cedars M, Naftolin F, Santoro N, Miller V, Harman S, Dowling N, Gleason C. Cardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial. Menopause The Journal Of The North American Menopause Society 2023, 31: 10-17. PMID: 37989141, PMCID: PMC10756493, DOI: 10.1097/gme.0000000000002278.Peer-Reviewed Original ResearchConceptsKronos Early Estrogen Prevention StudyOral conjugated equine estrogenConjugated equine estrogensBetter cardiovascular healthHormone therapyEquine estrogensInsulin resistanceMenopausal womenCardiovascular healthClinical trialsHormone therapy trialsPerson clinic visitsDiastolic blood pressureHomeostasis model assessmentSelf-reported diabetesYears of onsetMultisite clinical trialLevels of glucoseMicronized progesteroneDiabetes medicationsStudy of participantsCardiometabolic effectsCardiometabolic outcomesClinic visitsBlood pressure
2017
Ovarian Sertoli-Leydig cell tumors: a single institution experience and review of the literature.
Gressel G, Buza N, Pal L. Ovarian Sertoli-Leydig cell tumors: a single institution experience and review of the literature. European Journal Of Gynaecological Oncology 2017, 38: 214-220. PMID: 29953783.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsChemotherapy, AdjuvantDisease-Free SurvivalFemaleHumansHyperandrogenismHysterectomyMiddle AgedNeoadjuvant TherapyNeoplasm GradingOvarian NeoplasmsOvariectomyPostmenopauseRetrospective StudiesSalpingectomySertoli-Leydig Cell TumorConceptsSertoli-Leydig cell tumorOvarian Sertoli-Leydig cell tumorPresent patient populationDisease-free survivalSingle institution experienceTertiary care institutionTime of diagnosisOnset of menopauseRisk of recurrenceSeries of casesAdjuvant chemotherapyMedian followPostmenopausal bleedingPostmenopausal patientsMedian ageMedian intervalClinical presentationDefinitive managementPathological findingsRetrospective reviewInstitution experiencePatient populationTreatment modalitiesCell tumorsTumor grade
2003
Eosinophilia and uterine leiomyosarcoma.
Pal L, Parkash V, Chambers JT. Eosinophilia and uterine leiomyosarcoma. Obstetrics And Gynecology 2003, 101: 1130-2. PMID: 12738126, DOI: 10.1016/s0029-7844(02)02338-4.Peer-Reviewed Original ResearchConceptsUterine leiomyosarcomaTissue eosinophiliaOffice-based endometrial biopsyPelvic lymph node dissectionTumor-associated tissue eosinophiliaLow-grade uterine leiomyosarcomaEvidence of leukocytosisMarked eosinophilic infiltratePreoperative laboratory assessmentLymph node dissectionTotal abdominal hysterectomyGynecologic oncology serviceTertiary care hospitalImmediate postoperative periodSpectrum of neoplasmsNormalization of valuesAbsolute eosinophiliaSystemic eosinophiliaSystemic leukocytosisAbdominal hysterectomyBlood eosinophiliaExploratory laparotomyNode dissectionPostmenopausal bleedingPostmenopausal women
1997
Comparison of office hysteroscopy, transvaginal ultrasonography and endometrial biopsy in evaluation of abnormal uterine bleeding.
Pal L, Lapensee L, Toth T, Isaacson K. Comparison of office hysteroscopy, transvaginal ultrasonography and endometrial biopsy in evaluation of abnormal uterine bleeding. JSLS Journal Of The Society Of Laparoscopic & Robotic Surgeons 1997, 1: 125-30. PMID: 9876659, PMCID: PMC3021277.Peer-Reviewed Original ResearchConceptsAbnormal uterine bleedingEndometrial biopsyIntrauterine lesionsUterine bleedingFocal intrauterine lesionsAbnormal bleedingOffice hysteroscopyTransvaginal ultrasonographyTransvaginal ultrasoundNormal endometrial biopsyTransvaginal ultrasound scanHormone replacement therapyProspective observational studyIncidence of lesionsNegative predictive valueEnlarged uterusEvaluatory approachRegular bleedingBleeding patternsPostmenopausal groupOutpatient settingReplacement therapyUltrasound scanObservational studyBleeding