2024
Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study
Gleason C, Dowling N, Kara F, James T, Salazar H, Simo C, Harman S, Manson J, Hammers D, Naftolin F, Pal L, Miller V, Cedars M, Lobo R, Malek-Ahmadi M, Kantarci K. Long-term cognitive effects of menopausal hormone therapy: Findings from the KEEPS Continuation Study. PLOS Medicine 2024, 21: e1004435. PMID: 39570992, PMCID: PMC11581397, DOI: 10.1371/journal.pmed.1004435.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAgedCognitionEstradiolEstrogen Replacement TherapyEstrogens, Conjugated (USP)FemaleHumansMenopauseMiddle AgedPostmenopauseProgesteroneConceptsOral conjugated equine estrogenLatent growth modelingLong-term cognitive effectsCognitive factor scoresCognitive benefitsCognitive performanceFactor scoresBaseline cognitionFollow-upClinical trialsEarly postmenopauseIn-person research visitsYears of follow-upRandomized to placeboMenopausal hormone therapyGlobal cognitive scoreNeuroimaging effectsCognitive measuresCognitive harmLongitudinal cohort studyCognitive changesCognitive slopesCognitive dataTest batteryCognitive function
2023
Cardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial
Kantarci K, Tosakulwong N, Lesnick T, Kara F, Kendall-Thomas J, Kapoor E, Fields J, James T, Lobo R, Manson J, Pal L, Hammers D, Malek-Ahmadi M, Cedars M, Naftolin F, Santoro N, Miller V, Harman S, Dowling N, Gleason C. Cardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial. Menopause The Journal Of The North American Menopause Society 2023, 31: 10-17. PMID: 37989141, PMCID: PMC10756493, DOI: 10.1097/gme.0000000000002278.Peer-Reviewed Original ResearchConceptsKronos Early Estrogen Prevention StudyOral conjugated equine estrogenConjugated equine estrogensBetter cardiovascular healthHormone therapyEquine estrogensInsulin resistanceMenopausal womenCardiovascular healthClinical trialsHormone therapy trialsPerson clinic visitsDiastolic blood pressureHomeostasis model assessmentSelf-reported diabetesYears of onsetMultisite clinical trialLevels of glucoseMicronized progesteroneDiabetes medicationsStudy of participantsCardiometabolic effectsCardiometabolic outcomesClinic visitsBlood pressure