Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation
Kara F, Tosakulwong N, Lesnick T, Fought A, Schwarz C, Senjem M, Fields J, Min P, Lowe V, Jack C, Bailey K, James T, Lobo R, Manson J, Pal L, Hammers D, Malek‐Ahmadi M, Cedars M, Naftolin F, Miller V, Harman S, Dowling M, Gleason C, Kantarci K. Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.073736.Peer-Reviewed Original ResearchGreater WMH volumeKronos Early Estrogen Prevention StudyHormone therapyPostmenopausal womenWMH volumeHigher SBPBlood pressureHT trialsMenopausal womenGreater white matter hyperintensity volumeWhite matter hyperintensity volumeGood CV healthHigher Blood PressureBlood pressure controlDiastolic blood pressureWhite matter injuryBetter cardiovascular healthAssociation of SBPAntihypertensive usersBaseline SBPPremenopausal womenCV healthHigher systolicCardiovascular healthPrevention StudyHigher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation
Kara F, Tosakulwong N, Lesnick T, Fought A, Schwarz C, Senjem M, Fields J, Min P, Lowe V, Jack C, Bailey K, James T, Lobo R, Manson J, Pal L, Hammers D, Malek‐Ahmadi M, Cedars M, Naftolin F, Miller V, Harman S, Dowling M, Gleason C, Kantarci K. Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with greater WMH more than a decade later in the KEEPS Continuation. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.081628.Peer-Reviewed Original ResearchGreater WMH volumeKronos Early Estrogen Prevention StudyHormone therapyPostmenopausal womenWMH volumeHigher SBPBlood pressureHT trialsMenopausal womenGreater white matter hyperintensity volumeWhite matter hyperintensity volumeGood CV healthHigher Blood PressureBlood pressure controlDiastolic blood pressureWhite matter injuryBetter cardiovascular healthAssociation of SBPAntihypertensive usersBaseline SBPPremenopausal womenCV healthHigher systolicCardiovascular healthPrevention StudyCardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial
Kantarci K, Tosakulwong N, Lesnick T, Kara F, Kendall-Thomas J, Kapoor E, Fields J, James T, Lobo R, Manson J, Pal L, Hammers D, Malek-Ahmadi M, Cedars M, Naftolin F, Santoro N, Miller V, Harman S, Dowling N, Gleason C. Cardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial. Menopause The Journal Of The North American Menopause Society 2023, 31: 10-17. PMID: 37989141, PMCID: PMC10756493, DOI: 10.1097/gme.0000000000002278.Peer-Reviewed Original ResearchConceptsKronos Early Estrogen Prevention StudyOral conjugated equine estrogenConjugated equine estrogensBetter cardiovascular healthHormone therapyEquine estrogensInsulin resistanceMenopausal womenCardiovascular healthClinical trialsHormone therapy trialsPerson clinic visitsDiastolic blood pressureHomeostasis model assessmentSelf-reported diabetesYears of onsetMultisite clinical trialLevels of glucoseMicronized progesteroneDiabetes medicationsStudy of participantsCardiometabolic effectsCardiometabolic outcomesClinic visitsBlood pressureHigher systolic and diastolic blood pressures in recently postmenopausal women are associated with higher white matter hyperintensity volume more than a decade later in the keeps continuation study
Kara F, Tosakulwong N, Lesnick T, Schwarz C, Senjem M, Fields J, Min P, Lowe V, Jack C, Bailey K, James T, Lobo R, Manson J, Pal L, Hammers D, Malek‐Ahmadi M, Cedars M, Naftolin F, Miller V, Harman S, Dowling N, Gleason C, Kantarci K. Higher systolic and diastolic blood pressures in recently postmenopausal women are associated with higher white matter hyperintensity volume more than a decade later in the keeps continuation study. Alzheimer's & Dementia 2023, 19 DOI: 10.1002/alz.064187.Peer-Reviewed Original ResearchKronos Early Estrogen Prevention StudyDiastolic blood pressureGreater WMH volumeWM injuryWMH volumeWM hyperintensitiesPostmenopausal womenBlood pressureMenopausal transitionRisk factorsHigher white matter hyperintensity volumeWaist/hip ratioWhite matter hyperintensity volumeHormone therapy trialsCVD risk factorsMenopausal hormone therapyWM integrityWhite matter injuryAssociation of BPBetter cardiovascular healthEarly postmenopausal stageLow-density lipoproteinContinuation studyTotal intracranial volumeBaseline SBPTestosterone effects on autonomic function in women with androgen excess polycystic ovary syndrome
Stone T, Cardozo L, Oluwatade T, Leone C, Okifo F, Reckelhoff J, Pal L, Stachenfeld N. Testosterone effects on autonomic function in women with androgen excess polycystic ovary syndrome. Physiology 2023, 38: 5729543. DOI: 10.1152/physiol.2023.38.s1.5729543.Peer-Reviewed Original ResearchLower body negative pressureBlood pressureHormone interventionSympathetic baroreflexAutonomic functionSimilar systolic blood pressureGonadotropin-releasing hormone antagonistInsulin-resistant womenDiastolic blood pressurePolycystic ovary syndromeSystolic blood pressureCardiovascular autonomic controlBody negative pressureMSNA activitySerum angiotensinOvarian syndromeOvary syndromeResistant womenBaroreflex sensitivityHormone suppressionSerum aldosteroneAutonomic perturbationsT elevationHormone antagonistElevated androgens