2020
Pragmatic approach to neuraxial anesthesia in obstetric patients with disorders of the vertebral column, spinal cord and neuromuscular system
Walsh E, Zhang Y, Madden H, Lehrich J, Leffert L. Pragmatic approach to neuraxial anesthesia in obstetric patients with disorders of the vertebral column, spinal cord and neuromuscular system. Regional Anesthesia & Pain Medicine 2020, 46: 258-267. PMID: 33115718, DOI: 10.1136/rapm-2020-101792.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesia, ObstetricalAnesthesia, ObstetricalAnesthesia, SpinalCesarean SectionFemaleHumansPregnancyRetrospective StudiesSpinal CordSpineConceptsNeuraxial anesthesiaObstetric patientsSpinal cordCesarean delivery anesthesiaCesarean deliveryLabor analgesiaNeuraxial analgesiaVertebral columnCase seriesGeneral anesthesiaObstetrical patientsRetrospective studyDelivery anesthesiaPatient injuryAnesthesiaPatient harmPatientsNarrative reviewAvailable evidenceUnwarranted fearsNeuromuscular systemAdditional riskPresent unique challengesAnalgesiaCord
2019
Risk Factors, Etiologies, and Screening Tools for Sepsis in Pregnant Women
Bauer ME, Housey M, Bauer ST, Behrmann S, Chau A, Clancy C, Clark EAS, Einav S, Langen E, Leffert L, Lin S, Madapu M, Maile MD, McQuaid-Hanson E, Priessnitz K, Sela HY, Shah A, Sobolewski P, Toledo P, Tsen LC, Bateman BT. Risk Factors, Etiologies, and Screening Tools for Sepsis in Pregnant Women. Anesthesia & Analgesia 2019, Publish Ahead of Print: &na;. PMID: 31743182, PMCID: PMC7543988, DOI: 10.1213/ane.0000000000003709.Peer-Reviewed Original ResearchConceptsSystemic inflammatory response syndromeQuick Sequential Organ Failure AssessmentRisk factorsDelivery hospitalizationsMaternal sepsisSepsis casesCommon causeMortality rateMaternal Early Warning CriteriaSequential Organ Failure AssessmentScreening toolHours of diagnosisTiming of antibioticsOrgan Failure AssessmentCohort of patientsInflammatory response syndromePotential risk factorsHalf of casesAcademic medical centerDate of deliveryQSOFA criteriaControl patientsAntibiotic therapyResponse syndromeSignificant morbidityIs Insufficient Evidence Sufficient?
Leffert LR. Is Insufficient Evidence Sufficient? Anesthesia & Analgesia 2019, 129: 1202-1204. PMID: 31613810, DOI: 10.1213/ane.0000000000004437.Peer-Reviewed Original ResearchFemaleHumansObstetricsPost-Dural Puncture HeadachePregnancyPregnancy ComplicationsRetrospective Studies
2018
Timing and Risk Factors of Postpartum Stroke
Too G, Wen T, Boehme AK, Miller EC, Leffert LR, Attenello FJ, Mack WJ, D'Alton M, Friedman AM. Timing and Risk Factors of Postpartum Stroke. Obstetrics And Gynecology 2018, 131: 70-78. PMID: 29215510, PMCID: PMC6402829, DOI: 10.1097/aog.0000000000002372.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCohort StudiesConfidence IntervalsCost-Benefit AnalysisDatabases, FactualFemaleHumansHypertension, Pregnancy-InducedMaternal AgeOdds RatioPatient DischargePatient ReadmissionPostpartum PeriodPre-EclampsiaPregnancyPregnancy, High-RiskPrognosisRetrospective StudiesRisk AssessmentStrokeTime FactorsYoung AdultConceptsChronic hypertensionDays of dischargeNationwide Readmissions DatabaseHypertensive diseasePostpartum strokeStroke readmissionDelivery hospitalizationsIndex hospitalizationOdds ratioUtilization Project Nationwide Readmissions DatabaseOptimal blood pressure managementDelivery hospitalization dischargeRetrospective cohort studyBlood pressure managementRisk of readmissionCases of strokeMajority of readmissionsCases of readmissionCalendar year 2013Hospitalization dischargeCohort studyHospital dischargeMedian timeReadmission riskRisk factors
2015
Pregnancy complications in women with rare tumor suppressor syndromes affecting central and peripheral nervous system
Terry AR, Merker VL, Barker FG, Leffert L, Bateman BT, Souter I, Plotkin SR. Pregnancy complications in women with rare tumor suppressor syndromes affecting central and peripheral nervous system. American Journal Of Obstetrics And Gynecology 2015, 213: 108-109. PMID: 25687565, DOI: 10.1016/j.ajog.2015.02.013.Peer-Reviewed Original Research
2013
Neurofibromatosis type 1 and pregnancy complications: a population-based study
Terry AR, Barker FG, Leffert L, Bateman BT, Souter I, Plotkin SR. Neurofibromatosis type 1 and pregnancy complications: a population-based study. American Journal Of Obstetrics And Gynecology 2013, 209: 46.e1-46.e8. PMID: 23535241, DOI: 10.1016/j.ajog.2013.03.029.Peer-Reviewed Original ResearchMeSH KeywordsAdultCesarean SectionFemaleFetal Growth RetardationHumansHypertension, Pregnancy-InducedInfant, NewbornInternational Classification of DiseasesLogistic ModelsMaternal MortalityNeurofibromatosis 1Obstetric Labor, PrematurePre-EclampsiaPregnancyPregnancy ComplicationsRetrospective StudiesUnited StatesConceptsNeurofibromatosis type 1Diagnosis of NF1Deep venous thrombosis/pulmonary embolismPopulation-based retrospective cohort studyVenous thrombosis/pulmonary embolismType 1Pregnancy-related admissionsPregnancy-related hospitalizationsRetrospective cohort studyGeneral obstetric populationAcute cardiac eventsIntrauterine growth restrictionMultivariable logistic regressionPopulation-based studyGestational hypertensionMaternal morbidityObstetric populationPregnancy complicationsPreterm laborCardiac eventsCesarean deliveryCohort studyPeripartum complicationsPulmonary embolismCerebrovascular disease
2012
Outcomes of hospitalization in pregnant women with CNS neoplasms: a population-based study
Terry AR, Barker FG, Leffert L, Bateman BT, Souter I, Plotkin SR. Outcomes of hospitalization in pregnant women with CNS neoplasms: a population-based study. Neuro-Oncology 2012, 14: 768-776. PMID: 22513749, PMCID: PMC3367848, DOI: 10.1093/neuonc/nos078.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBostonBrain NeoplasmsCesarean SectionChildDelivery, ObstetricFemaleFetal Growth RetardationFollow-Up StudiesHospitalizationHumansMaternal MortalityObstetric Labor, PrematurePregnancyPregnancy Complications, NeoplasticPregnancy OutcomeRetrospective StudiesRisk FactorsSpinal NeoplasmsSurvival RateYoung AdultConceptsBenign brain tumorsIntrauterine growth restrictionMalignant brain tumorsNationwide Inpatient SamplePopulation-based studyCNS neoplasmsBrain tumorsCaesarean deliveryPreterm laborSpine tumorsPregnancy outcomesMaternal mortalityPregnancy-related admissionsAdverse pregnancy outcomesRetrospective cohort studyOutcomes of hospitalizationLogistic regression modelsPregnancy complicationsCohort studyHyperemesis gravidarumSurgical patientsObstetric riskPregnant womenInpatient SampleGrowth restriction