2008
Differential Expression of the Human CD8β Splice Variants and Regulation of the M-2 Isoform by Ubiquitination
Thakral D, Dobbins J, Devine L, Kavathas PB. Differential Expression of the Human CD8β Splice Variants and Regulation of the M-2 Isoform by Ubiquitination. The Journal Of Immunology 2008, 180: 7431-7442. PMID: 18490743, DOI: 10.4049/jimmunol.180.11.7431.Peer-Reviewed Original ResearchConceptsCytoplasmic tailSplice variantsExpression patternsCell surfaceDifferent cytoplasmic tailsGene splice variantsMRNA expression patternsMRNA levelsFluorescent chimerasHuman genesHuman lineageDifferential mRNA expression patternsHeterodimer functionsExtracellular domainLysine residuesQuantitative RT-PCRDifferential expressionLysosomal compartmentTCR complexFunctional significanceIsoformsCD8B geneUbiquitinationCell linesPrimary human
2002
A Non-class I MHC Intestinal Epithelial Surface Glycoprotein, gp180, Binds to CD8
Campbell N, Park M, Toy L, Yio X, Devine L, Kavathas P, Mayer L. A Non-class I MHC Intestinal Epithelial Surface Glycoprotein, gp180, Binds to CD8. Clinical Immunology 2002, 102: 267-274. PMID: 11890713, DOI: 10.1006/clim.2001.5170.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptionAdaptor Proteins, Signal TransducingAnti-Bacterial AgentsAntibodies, MonoclonalBlotting, WesternCarcinoma, HepatocellularCarrier ProteinsCD40 AntigensCD8-Positive T-LymphocytesEnterocytesEnzyme-Linked Immunosorbent AssayEpitopesExtracellular Matrix ProteinsHumansImmediate-Early ProteinsLiver NeoplasmsMembrane GlycoproteinsPhosphorylationProteinsRecombinant Fusion ProteinsSequestosome-1 ProteinTransfectionTumor Cells, CulturedTunicamycinConceptsActivation of CD8T cellsIntestinal epithelial cellsCD8 moleculesEpithelial cellsMucosal immune responsesClass I MHCNormal intestinal epithelial cellsT cell activationMurine T cellsCD8 alphaImmune responseCytolytic activityI MHCCell activationMixed cell culture systemCD8Human CD8 alphaMonoclonal antibodiesCell culture systemActivationSurface glycoproteinTyrosine kinaseCellsGp180