2010
Kv1.3 is the exclusive voltage‐gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count
McCloskey C, Jones S, Amisten S, Snowden RT, Kaczmarek LK, Erlinge D, Goodall AH, Forsythe ID, Mahaut‐Smith M. Kv1.3 is the exclusive voltage‐gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count. The Journal Of Physiology 2010, 588: 1399-1406. PMID: 20308249, PMCID: PMC2876798, DOI: 10.1113/jphysiol.2010.188136.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood PlateletsCalcium SignalingCell SizeDNA, ComplementaryHumansIn Vitro TechniquesKv1.3 Potassium ChannelMegakaryocytesMembrane PotentialsMiceMice, Inbred C57BLPatch-Clamp TechniquesPlatelet CountReverse Transcriptase Polymerase Chain ReactionScorpion VenomsSecond Messenger SystemsConceptsLarge ionic conductanceMembrane potentialHuman plateletsKv alphaMegakaryocyte developmentAncillary subunitsQuantitative RT-PCRMolecular levelKv channelsRole of Kv1.3MegakaryocytesKv1.3RT-PCRWild-type miceKv currentsSubunitsSignalingMiceApoptosisMargatoxinPlatelet activationRoleIonic conductancesPlateletsActivation
1997
Localization of a high threshold potassium channel in the rat cochlear nucleus
Perney T, Kaczmarek L. Localization of a high threshold potassium channel in the rat cochlear nucleus. The Journal Of Comparative Neurology 1997, 386: 178-202. PMID: 9295146, DOI: 10.1002/(sici)1096-9861(19970922)386:2<178::aid-cne2>3.0.co;2-z.Peer-Reviewed Original ResearchConceptsCochlear nucleusBushy cellsKv3.1 mRNAKv3.1 channelsPotassium channelsDorsal cochlear nucleusRat cochlear nucleusVentral cochlear nucleusLarge synaptic potentialsTypes of neuronsProximal dendritesSynaptic potentialsAxon terminalsStained neuronsUnmyelinated axonsAuditory neuronsNeuronal firingOctopus cellsMultipolar cellsGiant cellsKv3.1 proteinNeuronsKv3.1Situ hybridizationImmunolabeling