2024
Disease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neurons
Wu J, Quraishi I, Zhang Y, Bromwich M, Kaczmarek L. Disease-causing Slack potassium channel mutations produce opposite effects on excitability of excitatory and inhibitory neurons. Cell Reports 2024, 43: 113904. PMID: 38457342, PMCID: PMC11013952, DOI: 10.1016/j.celrep.2024.113904.Peer-Reviewed Original ResearchInhibitory neuronsRegulation of neuronal excitabilityPotassium channel mutationsVoltage-dependent sodiumInhibitory cortical neuronsGain-of-function mutationsAxon initial segmentKCNT1 geneNeuronal excitabilityChannel subunitsChannel mutationsNetwork hyperexcitabilityMouse modelNeuron typesCortical neuronsTreat epilepsyNeuronsExcitable neuronsNeurological disordersSevere intellectual disabilityMutationsInitial segmentKCNT1ExpressionHyperexcitability
2015
Diversity in the Structure and Function of Ion Channels
Levitan I, Kaczmarek L. Diversity in the Structure and Function of Ion Channels. 2015, 127-150. DOI: 10.1093/med/9780199773893.003.0007.ChaptersIon channelsPotassium channelsFormation of heterotetramersAlternative splicingIndividual genesMultiple genesAuxiliary subunitsTwo-poreDiverse familyHuman diseasesMolecular biologyMessenger RNASubunitsDiversityGenesRectifier channelsVoltage-dependent sodiumChannel propertiesPatch-clamp techniqueSplicingDifferent mechanismsHeterotetramerClamp techniqueElectrophysiological measurementsRNA
1990
Transfection of activated ras into an excitable cell line (AtT-20) alters tetrodotoxin sensitivity of voltage-dependent sodium current
Flamm R, Birnberg N, Kaczmarek L. Transfection of activated ras into an excitable cell line (AtT-20) alters tetrodotoxin sensitivity of voltage-dependent sodium current. Pflügers Archiv - European Journal Of Physiology 1990, 416: 120-125. PMID: 2191273, DOI: 10.1007/bf00370232.Peer-Reviewed Original ResearchConceptsTTX-sensitive currentsResistant currentSodium currentTTX-resistant sodium currentsVoltage-dependent sodium currentsSodium channel blocker tetrodotoxinTTX-resistant currentChannel blocker tetrodotoxinAnterior pituitary tumorsVoltage-dependent sodiumCell linesC-Ha-ras geneTTX-sensitiveBlocker tetrodotoxinPituitary tumorsExcitable cell lineC-Ha-ras oncogeneTetrodotoxin sensitivityTetrodotoxinAtT-20 cellsControl cellsCellsRate of inactivationTransfectionTumors