2001
Title Pages
B.Levitan I, Kaczmarek L. Title Pages. 2001, i-iv. DOI: 10.1093/oso/9780195145236.002.0001.Peer-Reviewed Original ResearchElectrical activityAppropriate synaptic connectionsAction of neurotransmittersBiochemical pathwaysMolecular mechanismsMolecular biologyUndifferentiated cellsIon channelsCellular propertiesSynaptic connectionsNerve cellsNeuronsSensory cellsSynaptic junctionsMolecular factorsSingle neuronsFirst courseCellsGenomeBiologyVaried patternsNeurotransmittersHormoneSecretionActivityNeurotransmitters and Neurohormones
B.Levitan I, Kaczmarek L. Neurotransmitters and Neurohormones. 2001, 223-252. DOI: 10.1093/oso/9780195145236.003.0010.Peer-Reviewed Original Research
1998
Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits
Joiner W, Tang M, Wang L, Dworetzky S, Boissard C, Gan L, Gribkoff V, Kaczmarek L. Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits. Nature Neuroscience 1998, 1: 462-469. PMID: 10196543, DOI: 10.1038/2176.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsElectric ConductivityIntermediate-Conductance Calcium-Activated Potassium ChannelsIsomerismLarge-Conductance Calcium-Activated Potassium ChannelsMolecular Sequence DataNerve Tissue ProteinsPotassium ChannelsPotassium Channels, Calcium-ActivatedPotassium Channels, Sodium-ActivatedConceptsCalcium-activated potassium channelsIntracellular calciumNervous systemIntermediate-conductance calcium-activated potassium channelsPotassium channelsLarge-conductance calcium-activated potassium channelsControl of excitabilitySlo subunitIntermediate conductance channelPotassium channel genesPharmacological propertiesIntermediate conductanceCytoplasmic calciumChannel subunitsSlo channelsSlack channelsChannel genesSingle-channel conductanceUnitary conductanceCalciumExcitabilitySLOSecretion
1997
The Secretion of Classical and Peptide Cotransmitters from a Single Presynaptic Neuron Involves a Synaptobrevin-Like Molecule
Whim M, Niemann H, Kaczmarek L. The Secretion of Classical and Peptide Cotransmitters from a Single Presynaptic Neuron Involves a Synaptobrevin-Like Molecule. Journal Of Neuroscience 1997, 17: 2338-2347. PMID: 9065494, PMCID: PMC6573516, DOI: 10.1523/jneurosci.17-07-02338.1997.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAnimalsAplysiaCalciumCells, CulturedCoculture TechniquesElectric ConductivityGanglia, InvertebrateKineticsMagnesiumMembrane PotentialsMembrane ProteinsNerve Tissue ProteinsNeuronsNeurons, AfferentNeuropeptidesPatch-Clamp TechniquesPresynaptic TerminalsRecombinant ProteinsR-SNARE ProteinsSynapsesTetanus ToxinConceptsClassical transmittersSingle presynaptic neuronRelease of neuropeptidesSingle action potentialPresynaptic release sitesSecretion of peptidesNeuron B2Peptidergic synapsesSynaptic typesSensory neuronsPresynaptic neuronsTetanus toxinPeptide cotransmittersAction potentialsPresynaptic injectionSecretionNeuronsMolecular mechanismsSynapseTypes of transmittersB2CotransmitterNeuropeptidesPeptidesReleaseRegulation by insulin of a unique neuronal Ca2+ pool and of neuropeptide secretion
Jonas E, Knox R, Smith T, Wayne N, Connor J, Kaczmarek L. Regulation by insulin of a unique neuronal Ca2+ pool and of neuropeptide secretion. Nature 1997, 385: 343-346. PMID: 9002519, DOI: 10.1038/385343a0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBenzoquinonesCalciumCalcium ChannelsCells, CulturedCyclic AMPEndoplasmic ReticulumHeparinInositol 1,4,5-TrisphosphateInositol 1,4,5-Trisphosphate ReceptorsInsulinInvertebrate HormonesLactams, MacrocyclicNeuronsNeuropeptidesProtein-Tyrosine KinasesQuinonesReceptors, Cytoplasmic and NuclearRifabutinThapsigarginConceptsIntracellular Ca2Neuropeptide secretionSpontaneous action potentialsEffect of insulinSecretion of neuropeptidesTyrosine kinase receptorsAcute riseBag cell neuronsDistal tipNeuronal dischargeNeuronal Ca2Distinct intracellular poolsCell neuronsAction potentialsCyclic AMP analogueInsulinNeuropeptidesInsulin receptorKinase receptorsSecretionPresumed siteNeuronsIntracellular poolMitochondrial Ca2Receptors
1994
A shab potassium channel contributes to action potential broadening in peptidergic neurons
Quattrocki E, Marshall J, Kaczmarek L. A shab potassium channel contributes to action potential broadening in peptidergic neurons. Neuron 1994, 12: 73-86. PMID: 8292361, DOI: 10.1016/0896-6273(94)90153-8.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAmino Acid SequenceAnimalsAplysiaBase SequenceCloning, MolecularDNA, ComplementaryFemaleInvertebrate HormonesKineticsMathematicsModels, TheoreticalMolecular Sequence DataNeuronsOocytesPolymerase Chain ReactionPotassiumPotassium ChannelsShab Potassium ChannelsTetraethylammoniumTetraethylammonium CompoundsTranscription, GeneticXenopus laevis
1991
Dexamethasone increases potassium channel messenger RNA and activity in clonal pituitary cells.
Levitan E, Hemmick L, Birnberg N, Kaczmarek L. Dexamethasone increases potassium channel messenger RNA and activity in clonal pituitary cells. Endocrinology 1991, 5: 1903-8. PMID: 1791837, DOI: 10.1210/mend-5-12-1903.Peer-Reviewed Original ResearchConceptsPituitary cellsChannel expressionClonal rat pituitary cellsChannel messenger RNAIon channel expressionRat pituitary cellsDose-dependent mannerClonal pituitary cellsAnterior pituitaryLong-term effectsRat hypothalamusSimilar pharmacologyGlucocorticoid agonistGlucocorticoid hormonesChannel mRNAGH3 cellsElectrical activitySecretionSteady-state concentrationsTerm effectsPituitaryExcitable cellsHormoneIon channelsMessenger RNANeuropeptide inhibition of voltage-gated calcium channels mediated by mobilization of intracellular calcium
Kramer R, Kaczmarek L, Levitan E. Neuropeptide inhibition of voltage-gated calcium channels mediated by mobilization of intracellular calcium. Neuron 1991, 6: 557-563. PMID: 1849723, DOI: 10.1016/0896-6273(91)90058-8.Peer-Reviewed Original ResearchConceptsThyrotropin-releasing hormoneVoltage-gated calcium channelsVoltage-gated Ca2Protein kinase CInactivation of Ca2Pituitary tumor cellsVariety of agentsHormone secretionNeurotransmitter inhibitionIntracellular calciumResult of Ca2Calcium channelsIntracellular Ca2Inhibits Ca2Kinase CEndocrine cellsRoutine useTumor cellsPatch-clamp electrodesPlasma membrane channelsDependent inactivationInhibitionHormoneSecretionCa2
1985
Inhibitors of calcium-dependent enzymes prevent the onset of afterdischarge in the peptidergic bag cell neurons of Aplysia
DeRiemer S, Schweitzer B, Kaczmarek L. Inhibitors of calcium-dependent enzymes prevent the onset of afterdischarge in the peptidergic bag cell neurons of Aplysia. Brain Research 1985, 340: 175-180. PMID: 4027644, DOI: 10.1016/0006-8993(85)90790-5.Peer-Reviewed Original ResearchConceptsBag cell neuronsCalcium-dependent enzymesCell neuronsNeuroactive peptidesAttenuation of secretionOnset of afterdischargeBrief electrical stimulationPeptidergic bag cell neuronsAbility of stimulationEffect of TFPEffects of agentsNeuronal excitabilitySynaptic transmissionAfterdischargesNeurosecretory neuronsElectrical stimulationEndogenous burstingNeuronsSecretionCalmodulin-dependent enzymesProtein kinaseAplysiaStimulationOnsetAgents