2016
T Cell Receptor Mediated Calcium Entry Requires Alternatively Spliced Cav1.1 Channels
Matza D, Badou A, Klemic KG, Stein J, Govindarajulu U, Nadler MJ, Kinet JP, Peled A, Shapira OM, Kaczmarek LK, Flavell RA. T Cell Receptor Mediated Calcium Entry Requires Alternatively Spliced Cav1.1 Channels. PLOS ONE 2016, 11: e0147379. PMID: 26815481, PMCID: PMC4729531, DOI: 10.1371/journal.pone.0147379.Peer-Reviewed Original Research
2015
Signaling in the Brain
Levitan I, Kaczmarek L. Signaling in the Brain. 2015, 3-22. DOI: 10.1093/med/9780199773893.003.0001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsHow Neurons Communicate: Gap Junctions and Neurosecretion
Levitan I, Kaczmarek L. How Neurons Communicate: Gap Junctions and Neurosecretion. 2015, 153-186. DOI: 10.1093/med/9780199773893.003.0008.ChaptersSynaptic vesiclesSNARE complex proteinsExistence of proteinsSecretion of neurotransmittersComplex proteinsPlasma membraneCytoplasmic vesiclesProteinVesiclesAdjacent cellsGap junctionsSmall moleculesCalcium entryExternal mediumElectrical couplingMembraneNeurosecretionCellsComplex processEndocytosisExocytosisFluorescent dyeMoleculesConnexinsCytoplasmNeurotransmitters and Neurohormones
Levitan I, Kaczmarek L. Neurotransmitters and Neurohormones. 2015, 213-238. DOI: 10.1093/med/9780199773893.003.0010.ChaptersNervous systemNearby glial cellsRole of neurotransmittersSpecific transporter proteinsExtracellular spaceGlial cellsNerve terminalsPresynaptic terminalsTransporter proteinsIntercellular communicationTarget cellsGreat diversityNeuropeptidesNeurotransmittersMultitude of chemicalsCellsAcetylcholineReuptakeCatecholaminesGABANeuronsNeurohormonesReceptors and Transduction Mechanisms I: Receptors Coupled Directly to Ion Channels
Levitan I, Kaczmarek L. Receptors and Transduction Mechanisms I: Receptors Coupled Directly to Ion Channels. 2015, 239-262. DOI: 10.1093/med/9780199773893.003.0011.ChaptersReceptors and Transduction Mechanisms II: Indirectly Coupled Receptor/Ion Channel Systems
Levitan I, Kaczmarek L. Receptors and Transduction Mechanisms II: Indirectly Coupled Receptor/Ion Channel Systems. 2015, 263-294. DOI: 10.1093/med/9780199773893.003.0012.ChaptersProtein phosphorylationSecond messenger-dependent protein kinasesReceptor-channel couplingIon channel proteinsAppropriate biological responseExtracellular signalsDirect phosphorylationSpecific membrane receptorsProtein kinaseRegulatory componentsChannel proteinsSecond messenger systemsMembrane receptorsTransduction mechanismsIon channelsPhosphorylationBiological responsesMessenger systemsIon channel systemsDiversityTarget cellsSignal recognitionNeuronal excitabilityCellsKinaseSensory Receptors
Levitan I, Kaczmarek L. Sensory Receptors. 2015, 295-326. DOI: 10.1093/med/9780199773893.003.0013.ChaptersNeuronal Growth and Trophic Factors
Levitan I, Kaczmarek L. Neuronal Growth and Trophic Factors. 2015, 353-386. DOI: 10.1093/med/9780199773893.003.0015.ChaptersMolecular genetic approachesMature nervous systemGrowth factorNeuronal determinationTranscription factorsGenetic approachesKey growth factorsNeural developmentStem cellsTypes of neuronsNearby cellsNeuronal growthMechanism of actionMedical therapySympathetic neuronsMotor neuronsTrophic factorsNervous systemSteroid hormonesNeuronsDrosophilaCellsDevelopmental factorsGeneticsDifferentiationThe Birth and Death of a Neuron
Levitan I, Kaczmarek L. The Birth and Death of a Neuron. 2015, 329-352. DOI: 10.1093/med/9780199773893.003.0014.ChaptersNervous systemComplement of genesOuter mitochondrial membraneBone morphogenetic proteinNew neuronsNeuronal determinationTranscription factorsMitochondrial membraneBrain regionsMorphogenetic proteinsNeural inducersSpecific neuronsNeuronsEarly stepsNormal formationAction of factorsHigh rateDeathBirthVariety of factorsCellsFactorsGenesForm and Function in Cells of the Brain
Levitan I, Kaczmarek L. Form and Function in Cells of the Brain. 2015, 23-38. DOI: 10.1093/med/9780199773893.003.0002.Chapters
2006
Mitochondrial factors with dual roles in death and survival
Cheng WC, Berman SB, Ivanovska I, Jonas EA, Lee SJ, Chen Y, Kaczmarek LK, Pineda F, Hardwick JM. Mitochondrial factors with dual roles in death and survival. Oncogene 2006, 25: 4697-4705. PMID: 16892083, DOI: 10.1038/sj.onc.1209596.Peer-Reviewed Original ResearchConceptsBcl-2 family proteinsCell deathCell death regulatorsPro-death Bcl-2 family proteinNormal cellular functionMitochondrial fission proteinDeath regulatorsDeath stimuliCellular functionsFamily proteinsMitochondrial factorsFission proteinsCell survivalBiochemical mechanismsCaspasesDual roleProteinHealthy cellsCellsMammalsMitochondriaRegulatorSurvivalDeathStretch
2002
HSV-1 Helper Virus 5dl1.2 Suppresses Sodium Currents in Amplicon-Transduced Neurons
White BH, Cummins TR, Wolf DH, Waxman SG, Russell DS, Kaczmarek LK. HSV-1 Helper Virus 5dl1.2 Suppresses Sodium Currents in Amplicon-Transduced Neurons. Journal Of Neurophysiology 2002, 87: 2149-2157. PMID: 11929932, DOI: 10.1152/jn.00498.2001.Peer-Reviewed Original ResearchConceptsSodium currentAnti-HSV antibodiesAverage spike frequencyWild-type HSV-1Helper virusViral-based strategiesDays of transductionCultured neuronsHSV-1Spike frequencyGene deliveryNeuronsMammalian neuronsAmplicon systemSimilar suppressionHSV-1 genesVirusTherapeutic purposesViral proteinsAmplicon preparationsCellsCoinfectionSuppressionPreparation resultsTiters
2001
Title Pages
B.Levitan I, Kaczmarek L. Title Pages. 2001, i-iv. DOI: 10.1093/oso/9780195145236.002.0001.Peer-Reviewed Original ResearchElectrical activityAppropriate synaptic connectionsAction of neurotransmittersBiochemical pathwaysMolecular mechanismsMolecular biologyUndifferentiated cellsIon channelsCellular propertiesSynaptic connectionsNerve cellsNeuronsSensory cellsSynaptic junctionsMolecular factorsSingle neuronsFirst courseCellsGenomeBiologyVaried patternsNeurotransmittersHormoneSecretionActivityPreface
B.Levitan I, Kaczmarek L. Preface. 2001, vii-viii. DOI: 10.1093/oso/9780195145236.002.0003.Peer-Reviewed Original ResearchElectrical activityBiochemical pathwaysMolecular mechanismsAppropriate synaptic connectionsMolecular biologyUndifferentiated cellsAction of neurotransmittersIon channelsCellular propertiesSensory cellsMolecular factorsSynaptic connectionsNerve cellsNeuronsSynaptic junctionsSingle neuronsCellsFirst courseGenomeBiologyPathwayActivityMechanismVaried patternsAccount of mechanismsPreface to the Second Edition
B.Levitan I, Kaczmarek L. Preface to the Second Edition. 2001, ix-x. DOI: 10.1093/oso/9780195145236.002.0004.Peer-Reviewed Original ResearchElectrical activityAppropriate synaptic connectionsBiochemical pathwaysAction of neurotransmittersMolecular mechanismsMolecular biologyUndifferentiated cellsIon channelsCellular propertiesSensory cellsMolecular factorsSynaptic connectionsNerve cellsNeuronsSynaptic junctionsSingle neuronsCellsFirst courseGenomeBiologyPathwayVaried patternsActivityMechanismNeurotransmittersPreface to the First Edition
B.Levitan I, Kaczmarek L. Preface to the First Edition. 2001, xi-xii. DOI: 10.1093/oso/9780195145236.002.0005.Peer-Reviewed Original ResearchElectrical activityBiochemical pathwaysMolecular mechanismsAppropriate synaptic connectionsAction of neurotransmittersMolecular biologyUndifferentiated cellsIon channelsCellular propertiesSensory cellsMolecular factorsSynaptic connectionsNerve cellsNeuronsSynaptic junctionsSingle neuronsCellsFirst courseGenomeBiologyPathwayActivityMechanismVaried patternsNeurotransmittersForm and Function in Cells of the Brain
B.Levitan I, Kaczmarek L. Form and Function in Cells of the Brain. 2001, 25-44. DOI: 10.1093/oso/9780195145236.003.0002.Peer-Reviewed Original ResearchElectrical Signaling in Neurons
B.Levitan I, Kaczmarek L. Electrical Signaling in Neurons. 2001, 47-66. DOI: 10.1093/oso/9780195145236.003.0003.Peer-Reviewed Original ResearchMembrane Ion Channels and Ion Currents
B.Levitan I, Kaczmarek L. Membrane Ion Channels and Ion Currents. 2001, 67-88. DOI: 10.1093/oso/9780195145236.003.0004.Peer-Reviewed Original ResearchPlasma membraneTransmembrane ion flowIon flowMembrane ion channelsMovement of chargeExcellent electrical insulatorTransmembrane ionIon currentIon channelsLipid bilayersMembrane potentialHydrophobic interiorEndogenous electrical activityIonsElectrical insulatorSmall inorganic ionsMembraneTemporal patternsBilayersCellsExternal stimuliInsulatorNerve cellsSpeciesEnergyIon Channels, Membrane Ion Currents, and the Action Potential
B.Levitan I, Kaczmarek L. Ion Channels, Membrane Ion Currents, and the Action Potential. 2001, 113-138. DOI: 10.1093/oso/9780195145236.003.0006.Peer-Reviewed Original ResearchIon channelsPotassium channel proteinIon currentDetailed mechanistic understandingMembrane proteinsMolecular detailsActive ion channelsChannel proteinsBiological membranesMechanistic understandingSingle-channel recordingsProteinMembrane ion currentsVoltage-clamp measurementsMembraneChannel recordingsCellsMacroscopic currentsClamp measurementsCurrentElectrical phenomenaVoltage clampCurrent chapterMacroscopic membranesPotassium current