2005
Aminoglycosides block the Kv3.1 potassium channel and reduce the ability of inferior colliculus neurons to fire at high frequencies
Liu S, Kaczmarek LK. Aminoglycosides block the Kv3.1 potassium channel and reduce the ability of inferior colliculus neurons to fire at high frequencies. Developmental Neurobiology 2005, 62: 439-452. PMID: 15547932, DOI: 10.1002/neu.20112.Peer-Reviewed Original ResearchConceptsInferior colliculus neuronsKv3.1 potassium channelColliculus neuronsKv3.1 currentsHearing lossAuditory neuronsPotassium channelsInhibition of Kv3.1Progressive hearing lossRate of repolarizationAuditory nucleiPotassium currentFiring propertiesPipette solutionAction potentialsNeuronsHigh frequencyEffect of streptomycinExtracellular TEAKv3.1 geneKv3.1 channelsAminoglycoside antibioticsStreptomycinKv3.1Presence of streptomycin
2001
Localization of two high‐threshold potassium channel subunits in the rat central auditory system
Li W, Kaczmarek L, Perney T. Localization of two high‐threshold potassium channel subunits in the rat central auditory system. The Journal Of Comparative Neurology 2001, 437: 196-218. PMID: 11494252, DOI: 10.1002/cne.1279.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAuditory PathwaysCochlear NucleusFemaleGene ExpressionGeniculate BodiesImmunohistochemistryIn Situ HybridizationInferior ColliculiNeuronsNeuropeptidesOligonucleotide ProbesOlivary NucleusPotassium ChannelsPotassium Channels, Voltage-GatedRatsRats, Sprague-DawleyRNA, MessengerShaw Potassium ChannelsConceptsAuditory neuronsKv3.1 mRNAPotassium channelsMost auditory neuronsBrainstem auditory neuronsRat central auditory systemAction potential thresholdSubpopulation of neuronsCentral auditory systemLateral superior oliveRat auditory systemAuditory systemVoltage-sensitive potassium channelsRapid deactivation kineticsPotassium channel subunitsTrapezoid bodyRat brainstemMedial nucleusVentral nucleusLateral lemniscusTerminal arborizationsSynaptic inputsAuditory nucleiSuperior oliveChannel expression
1999
Shaw‐like potassium currents in the auditory rhombencephalon throughout embryogenesis
Hendriks R, Morest D, Kaczmarek L. Shaw‐like potassium currents in the auditory rhombencephalon throughout embryogenesis. Journal Of Neuroscience Research 1999, 58: 791-804. PMID: 10583910, DOI: 10.1002/(sici)1097-4547(19991215)58:6<791::aid-jnr6>3.0.co;2-3.Peer-Reviewed Original ResearchConceptsPotassium currentNucleus magnocellularisOutward currentsWhole-cell patch recordingsInitial transient componentTransient outward currentsEarly neuronal developmentEarly neuronal differentiationHigh activation thresholdFirst synapsesAuditory nucleiPatch recordingsPotassium channel genesSynaptic functionCharacteristic response propertiesSynapses formNeuronal developmentNeuronal differentiationActivation thresholdDevelopmental appearanceTetraethylammoniumMagnocellularisEarly ageChannel genesNeuroblasts