2003
Modulation of Synaptic Transmission by the BCL-2 Family Protein BCL-xL
Jonas EA, Hoit D, Hickman JA, Brandt TA, Polster BM, Fannjiang Y, McCarthy E, Montanez MK, Hardwick JM, Kaczmarek LK. Modulation of Synaptic Transmission by the BCL-2 Family Protein BCL-xL. Journal Of Neuroscience 2003, 23: 8423-8431. PMID: 12968005, PMCID: PMC6740692, DOI: 10.1523/jneurosci.23-23-08423.2003.Peer-Reviewed Original ResearchConceptsBcl-2 family proteinsProtein Bcl-xLBcl-xLFamily proteinsMitochondrial membranePro-apoptotic cleavage productRecombinant Bcl-xLBcl-xL proteinMitochondrial calcium uptakePresynaptic terminalsInfluences synaptic transmissionCell deathGiant presynaptic terminalSynaptic transmissionChannel activityProteinSquid stellate ganglionMitochondriaCleavage productsSynaptic stabilityAdult brainPostsynaptic responsesCalcium uptakeMembranePatch pipette
2000
Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain
Monteggia L, Eisch A, Tang M, Kaczmarek L, Nestler E. Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain. Brain Research 2000, 81: 129-139. PMID: 11000485, DOI: 10.1016/s0169-328x(00)00155-8.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBrainCloning, MolecularCyclic Nucleotide-Gated Cation ChannelsHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsIn Situ HybridizationIon ChannelsMaleMembrane PotentialsModels, MolecularMolecular Sequence DataMultigene FamilyMuscle ProteinsNerve Tissue ProteinsOrgan SpecificityPotassium ChannelsProtein Structure, SecondaryRatsRats, Sprague-DawleyRNA, MessengerSequence AlignmentSequence Homology, Amino AcidTranscription, GeneticConceptsRat brainLower brain stem nucleiNeuronal pacemaker activityPrincipal relay nucleiBrain stem nucleiVentral cochlear nucleusAdult rat brainFacial motor nucleusCerebral cortexMotor nucleusStem nucleiTrapezoid bodyCochlear nucleusMamillary bodiesMedial habenulaRelay nucleiHCN1 expressionHCN1-4Olfactory bulbPontine nucleiAdult brainRhythmic firingPacemaker activitySupraoptic nucleusHCN4 expression