1990
Cyclic AMP regulates processing of neuropeptide precursor in bag cell neurons ofAplysia
Azhderian E, Kaczmarek L. Cyclic AMP regulates processing of neuropeptide precursor in bag cell neurons ofAplysia. Journal Of Molecular Neuroscience 1990, 2: 61-70. PMID: 1964064, DOI: 10.1007/bf02876912.Peer-Reviewed Original ResearchConceptsBag cell neuronsEgg-laying hormoneCell neuronsCAMP levelsPresence of tetrodotoxinBag cell clustersAdenylate cyclase activator forskolinELH prohormoneCyclase activator forskolinElevation of cAMPMembrane-permeant cAMP analogAbdominal ganglionControl clustersPermeant cAMP analogueAction potentialsNeuroactive peptidesTreatment of cellsProtein synthesis inhibitor anisomycinActivator forskolinNeuronsProhormoneAfterdischargesCyclic AMPTetrodotoxinComparative peptide mapping
1989
Protein kinase inhibitors selectively block phorbol ester- or forskolin- induced changes in excitability of Aplysia neurons
Conn P, Strong J, Azhderian E, Nairn A, Greengard P, Kaczmarek L. Protein kinase inhibitors selectively block phorbol ester- or forskolin- induced changes in excitability of Aplysia neurons. Journal Of Neuroscience 1989, 9: 473-479. PMID: 2537389, PMCID: PMC6569795, DOI: 10.1523/jneurosci.09-02-00473.1989.Peer-Reviewed Original ResearchConceptsProtein kinase CBag cell neuronsVoltage-dependent calcium currentsCAMP-PKPhorbol esterKinase CCell neuronsAction potentialsCalcium currentInhibitor of PKCProtein kinase inhibitorsPhorbol ester-induced enhancementKinase inhibitor 1Protein kinase inhibitor 1Adenylate cyclase activator forskolinCyclase activator forskolinProtein inhibitorGranule movementVoltage-dependent currentsCell action potentialsCAMP analogEffect of forskolinActivator forskolinPhorbol ester-induced changesNeuronal excitability