2016
Stimulation of Slack K+ Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex
Fleming MR, Brown MR, Kronengold J, Zhang Y, Jenkins DP, Barcia G, Nabbout R, Bausch AE, Ruth P, Lukowski R, Navaratnam DS, Kaczmarek LK. Stimulation of Slack K+ Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex. Cell Reports 2016, 16: 2281-2288. PMID: 27545877, PMCID: PMC5123741, DOI: 10.1016/j.celrep.2016.07.024.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsBiosensing TechniquesBithionolBridged Bicyclo Compounds, HeterocyclicCell MembraneCerebral CortexFragile X Mental Retardation ProteinGene Expression RegulationHEK293 CellsHumansIon TransportMiceMice, KnockoutMicrofilament ProteinsMutationNerve Tissue ProteinsNeuronsPatch-Clamp TechniquesPhosphorylationPotassium ChannelsPotassium Channels, Sodium-ActivatedPrimary Cell CultureProtein BindingRNA, Small InterferingSignal TransductionThiazolidinesXenopus laevisConceptsProtein phosphatase 1Plasma membraneProtein kinase C.C-terminal residuesPhactr-1Potassium channelsPhosphatase 1Terminal domainSlack channelsHuman mutationsKinase C.Sodium-activated potassium channelsPharmacological activatorsOptical biosensor assayChannel stimulationSlack currentsBiosensor assaysMembraneMutantsPhosphorylationIntellectual disabilityProteinMutationsSevere intellectual disabilityActivator
1987
The role of protein kinase C in the regulation of ion channels and neurotransmitter release
Kaczmarek L. The role of protein kinase C in the regulation of ion channels and neurotransmitter release. Trends In Neurosciences 1987, 10: 30-34. DOI: 10.1016/0166-2236(87)90122-6.Peer-Reviewed Original ResearchProtein kinase CKinase CLipid environmentSecond messengerIntact cellsPhysiological activatorTypes of cellsAmount of neurotransmitterIon channelsChloride channelsPhorbol esterDiacylglycerolSynthetic diacylglycerolNeurotransmitter releaseEnzymeActivatorHormonal stimulationRegulationCellsImportant roleNervous systemNerve cellsMessengerActivityRole
1986
Phorbol Esters, Protein Phosphorylation and the Regulation of Neuronal Ion Channels
Kaczmarek L. Phorbol Esters, Protein Phosphorylation and the Regulation of Neuronal Ion Channels. Journal Of Experimental Biology 1986, 124: 375-392. PMID: 2428907, DOI: 10.1242/jeb.124.1.375.Peer-Reviewed Original ResearchConceptsProtein kinase CKinase CProtein kinase C resultsPhorbol esterNeuronal ion channelsProtein phosphorylationPlasma membraneLipid environmentIntact cellsIon channelsSuch activatorsEndogenous diacylglycerolVertebratesDiacylglycerolSynthetic diacylglycerolPhosphatidyl serineActivatorEndogenous electrical propertiesInactive speciesSynaptic transmissionInvertebratesCalcium channelsKinasePhosphorylationNervous system