2024
Factors Underlying Reduced Hospitalizations for Myocardial Infarction During the COVID-19 Pandemic
Wilcock A, Zubizarreta J, Wadhera R, Yeh R, Zachrison K, Schwamm L, Mehrotra A. Factors Underlying Reduced Hospitalizations for Myocardial Infarction During the COVID-19 Pandemic. JAMA Cardiology 2024, 9 PMID: 39083317, PMCID: PMC11292572, DOI: 10.1001/jamacardio.2024.2031.Peer-Reviewed Original ResearchHospital encountersAcute myocardial infarctionCare avoidanceShort-term acute careAcute myocardial infarction incidenceAcute myocardial infarction ratesTemporal trendsCOVID-19 pandemicPatient characteristicsTraditional Medicare claimsCross-sectional studyPandemic-related changesAMI incidenceCOVID-19 death ratesAcute careMyocardial infarctionMedicare claimsMain OutcomesExcess deathsExcess mortalityStudy samplePrepandemic levelsTraditional MedicareUnited StatesCOVID-19
2019
Recent Myocardial Infarction is Associated With Increased Risk in Older Adults With Acute Ischemic Stroke Receiving Thrombolytic Therapy
Inohara T, Liang L, Kosinski A, Smith E, Schwamm L, Hernandez A, Bhatt D, Fonarow G, Peterson E, Xian Y. Recent Myocardial Infarction is Associated With Increased Risk in Older Adults With Acute Ischemic Stroke Receiving Thrombolytic Therapy. Journal Of The American Heart Association 2019, 8: e012450. PMID: 31327296, PMCID: PMC6761665, DOI: 10.1161/jaha.119.012450.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorRecent myocardial infarctionAcute ischemic strokeHistory of MIRisk of mortalityMyocardial infarctionAIS patientsIschemic strokeIntravenous recombinant tissue-type plasminogen activatorST-segment elevation myocardial infarctionSegment elevation myocardial infarctionMultivariate logistic regression modelGuidelines-Stroke hospitalsOnly medical therapyElevation myocardial infarctionTissue-type plasminogen activatorLogistic regression modelsHospital mortalityHospital outcomesSevere strokeMedical therapyThrombolytic therapyHigh riskInfarctionPatients
2017
Timely Reperfusion in Stroke and Myocardial Infarction Is Not Correlated
Sauser Zachrison K, Levine D, Fonarow G, Bhatt D, Cox M, Schulte P, Smith E, Suter R, Xian Y, Schwamm L. Timely Reperfusion in Stroke and Myocardial Infarction Is Not Correlated. Circulation Cardiovascular Quality And Outcomes 2017, 10: e003148. PMID: 28283469, PMCID: PMC5369604, DOI: 10.1161/circoutcomes.116.003148.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, Balloon, CoronaryDelivery of Health Care, IntegratedFemaleFibrinolytic AgentsHumansMaleMiddle AgedMyocardial ReperfusionOrganizational ObjectivesPatient Care TeamProspective StudiesQuality ImprovementQuality Indicators, Health CareRegistriesST Elevation Myocardial InfarctionStrokeThrombolytic TherapyTime FactorsTime-to-TreatmentTissue Plasminogen ActivatorUnited StatesConceptsST-segment elevation myocardial infarctionAcute ischemic strokeDTN timeD2B timeTimely reperfusionMyocardial infarctionHospital CompareGuidelines-Coronary Artery DiseaseHospital performanceHierarchical linear regression modelingEligible patientsGuidelines-StrokeNeedle timeSTEMI patientsBalloon timeIschemic strokeArtery diseaseHospital proportionLinear regression modelingProspective studyHospital differencesAIS carePatientsCare processesSpearman's rank correlation coefficient
2016
Temporal Trends in Care and Outcomes of Patients Receiving Fibrinolytic Therapy Compared to Primary Percutaneous Coronary Intervention: Insights From the Get With The Guidelines Coronary Artery Disease (GWTG‐CAD) Registry
Hira R, Bhatt D, Fonarow G, Heidenreich P, Ju C, Virani S, Bozkurt B, Petersen L, Hernandez A, Schwamm L, Eapen Z, Albert M, Liang L, Matsouaka R, Peterson E, Jneid H. Temporal Trends in Care and Outcomes of Patients Receiving Fibrinolytic Therapy Compared to Primary Percutaneous Coronary Intervention: Insights From the Get With The Guidelines Coronary Artery Disease (GWTG‐CAD) Registry. Journal Of The American Heart Association 2016, 5: e004113. PMID: 27792640, PMCID: PMC5121508, DOI: 10.1161/jaha.116.004113.Peer-Reviewed Original ResearchMeSH KeywordsAgedCohort StudiesDatabases, FactualFemaleFibrinolytic AgentsGuideline AdherenceHospital MortalityHumansMaleMiddle AgedOutcome and Process Assessment, Health CarePercutaneous Coronary InterventionPractice Guidelines as TopicRegistriesST Elevation Myocardial InfarctionThrombolytic TherapyTime-to-TreatmentConceptsPrimary percutaneous coronary interventionST-elevation myocardial infarctionDefect-free careUse of fibrinolysisPercutaneous coronary interventionPCI-capable hospitalsNeedle timeHospital mortalitySTEMI patientsBalloon timeCoronary interventionMedian doorUse of PCIGuidelines-Coronary Artery Disease databaseGuidelines-Coronary Artery Disease registryCoronary Artery Disease registryHospital mortality outcomesOutcomes of patientsMinutes of arrivalPPCI patientsTimely reperfusionReperfusion therapyFibrinolytic therapyMortality outcomesMyocardial infarction
2014
Use of Renin–Angiotensin System Blockers in Acute Coronary Syndromes
Bainey K, Armstrong P, Fonarow G, Cannon C, Hernandez A, Peterson E, Peacock W, Laskey W, Zhao X, Schwamm L, Bhatt D. Use of Renin–Angiotensin System Blockers in Acute Coronary Syndromes. Circulation Cardiovascular Quality And Outcomes 2014, 7: 227-235. PMID: 24569634, DOI: 10.1161/circoutcomes.113.000422.Peer-Reviewed Original ResearchConceptsAngiotensin receptor blockersAcute coronary syndromeACEI/angiotensin receptor blockerACEI/ARB therapyCoronary artery bypassCoronary syndromeAmerican CollegeARB therapyArtery bypassRenal insufficiencyMyocardial infarctionCardiology/American Heart Association class ICardiology/American Heart Association guidelinesGuidelines-Coronary Artery Disease programHospital coronary artery bypassRenin-angiotensin system blockersAmerican Heart Association guidelinesU.S. National RegistryHeart Association guidelinesRate of treatmentQuality improvement effortsEligible patientsSystem blockersReceptor blockersHospital discharge
2013
Relationship of Race/Ethnicity With Door‐to‐Balloon Time and Mortality in Patients Undergoing Primary Percutaneous Coronary Intervention for ST‐Elevation Myocardial Infarction: Findings From Get With the Guidelines–Coronary Artery Disease
Cavender M, Rassi A, Fonarow G, Cannon C, Peacock W, Laskey W, Hernandez A, Peterson E, Cox M, Grau‐Sepulveda M, Schwamm L, Bhatt D. Relationship of Race/Ethnicity With Door‐to‐Balloon Time and Mortality in Patients Undergoing Primary Percutaneous Coronary Intervention for ST‐Elevation Myocardial Infarction: Findings From Get With the Guidelines–Coronary Artery Disease. Clinical Cardiology 2013, 36: 749-756. PMID: 24085713, PMCID: PMC6649362, DOI: 10.1002/clc.22213.Peer-Reviewed Original ResearchMeSH KeywordsAgedBlack or African AmericanChi-Square DistributionFemaleGuideline AdherenceHealth Services AccessibilityHealthcare DisparitiesHispanic or LatinoHospital MortalityHumansLinear ModelsLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionOdds RatioPercutaneous Coronary InterventionPractice Guidelines as TopicProspective StudiesRegistriesRisk FactorsTime FactorsTime-to-TreatmentTreatment OutcomeUnited StatesWhite PeopleConceptsPrimary percutaneous coronary interventionPrimary PCIST-elevation myocardial infarctionDTB timeMedian DTB timeRace/ethnicityPercutaneous coronary interventionCoronary interventionArtery diseaseBalloon timeMyocardial infarctionGuidelines-Coronary Artery DiseaseProportion of patientsAfrican American raceAfrican AmericansAfrican American femalesDifferent races/ethnicitiesHospital mortalityD2B timeHispanic patientsHispanic ethnicityLower oddsAmerican racePatientsCrude differences
2012
Temporal Trends and Predictors in the Use of Aldosterone Antagonists Post-Acute Myocardial Infarction
Rassi A, Cavender M, Fonarow G, Cannon C, Hernandez A, Peterson E, Peacock W, Laskey W, Rosas S, Zhao X, Schwamm L, Bhatt D. Temporal Trends and Predictors in the Use of Aldosterone Antagonists Post-Acute Myocardial Infarction. Journal Of The American College Of Cardiology 2012, 61: 35-40. PMID: 23137936, DOI: 10.1016/j.jacc.2012.08.1019.Peer-Reviewed Original ResearchMeSH KeywordsAgedDiabetes MellitusDrug PrescriptionsDrug UtilizationFemaleGuideline AdherenceHeart FailureHospital Bed CapacityHumansKidney DiseasesMaleMineralocorticoid Receptor AntagonistsMultivariate AnalysisMyocardial InfarctionMyocardial RevascularizationPatient DischargePractice Guidelines as TopicRegistriesSmokingStroke VolumeUnited StatesConceptsPost-acute myocardial infarctionAldosterone antagonist useAldosterone antagonist therapyAldosterone antagonistsEjection fractionAntagonist useEligible patientsAntagonist therapyHospital dischargeHeart failureMyocardial infarctionActual prescribing patternsGuideline-based therapyAbsence of contraindicationsHistory of diabetesPost-AMI patientsHigher ejection fractionAmerican Heart AssociationLarger hospital sizeCoronary revascularizationPrescribing patternsAMI patientsKidney dysfunctionPost-AMITobacco abuseGuideline Adherence After ST-Segment Elevation Versus Non-ST Segment Elevation Myocardial Infarction
Somma K, Bhatt D, Fonarow G, Cannon C, Cox M, Laskey W, Peacock W, Hernandez A, Peterson E, Schwamm L, Saxon L. Guideline Adherence After ST-Segment Elevation Versus Non-ST Segment Elevation Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2012, 5: 654-661. PMID: 22949493, DOI: 10.1161/circoutcomes.111.963959.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overCardiovascular AgentsChi-Square DistributionComorbidityCoronary Artery DiseaseDrug Administration ScheduleFemaleGuideline AdherenceHospitalsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionOdds RatioPractice Guidelines as TopicPractice Patterns, Physicians'Quality Indicators, Health CareRegistriesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionSTEMI patientsMedical therapyNSTEMI patientsMyocardial infarctionGuidelines-Coronary Artery Disease registryNon-ST segment elevation myocardial infarctionGuideline-based medical therapyPrior coronary artery diseaseSegment elevation myocardial infarctionLow-density lipoprotein levelsSegment elevation MISimilar medical therapyLipid-lowering medicationsCoronary artery diseaseST-segment elevationGWTG-CADMedical comorbiditiesDischarge medicationsGuideline adherenceArtery diseaseHeart failureAngiotensin receptorsElevation MIPredictors of Adherence to Performance Measures in Patients with Acute Myocardial Infarction
Kumbhani D, Fonarow G, Cannon C, Hernandez A, Peterson E, Peacock W, Laskey W, Pan W, Schwamm L, Bhatt D, Committee and Investigators G. Predictors of Adherence to Performance Measures in Patients with Acute Myocardial Infarction. The American Journal Of Medicine 2012, 126: 74.e1-74.e9. PMID: 22925314, DOI: 10.1016/j.amjmed.2012.02.025.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionGuidelines-Coronary Artery Disease registryAcute myocardial infarction treatmentAdherence modelCertain high-risk populationsGuideline-recommended therapiesLogistic multivariable regression modelsHigh-risk populationGuideline-based carePredictors of adherenceQuality improvement interventionsMultivariable regression modelsMyocardial infarction treatmentEligible patientsHospital characteristicsWorse adherenceSummary scoresDisease RegistryInfarction treatmentPatientsImprovement interventionsGreater adherenceInfarctionAdherenceQuality of Care and Outcomes Among Patients With Acute Myocardial Infarction by Level of Kidney Function at Admission: Report From the Get With The Guidelines Coronary Artery Disease Program
Vasaiwala S, Cannon C, Fonarow G, Peacock W, Laskey W, Schwamm L, Liang L, Hernandez A, Peterson E, Rosas S, Bhatt D, Committee and Investigators G. Quality of Care and Outcomes Among Patients With Acute Myocardial Infarction by Level of Kidney Function at Admission: Report From the Get With The Guidelines Coronary Artery Disease Program. Clinical Cardiology 2012, 35: 541-547. PMID: 22744797, PMCID: PMC6652568, DOI: 10.1002/clc.22021.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionGuidelines-Coronary Artery Disease programChronic renal insufficiencyRenal insufficiencyGlomerular filtration rateRenal functionInpatient careAMI patientsKidney failureMyocardial infarctionDisease programsAMI performance measuresGuideline-recommended therapiesMild renal insufficiencyModerate renal insufficiencySevere renal dysfunctionNormal renal functionSevere renal insufficiencyAmerican Heart AssociationMultivariable regression analysisQuality of careHospital mortalityRenal dysfunctionPatient characteristicsAdjusted mortalityAge and Gender Differences in Quality of Care and Outcomes for Patients with ST-segment Elevation Myocardial Infarction
Bangalore S, Fonarow G, Peterson E, Hellkamp A, Hernandez A, Laskey W, Peacock W, Cannon C, Schwamm L, Bhatt D, Committee and Investigators G. Age and Gender Differences in Quality of Care and Outcomes for Patients with ST-segment Elevation Myocardial Infarction. The American Journal Of Medicine 2012, 125: 1000-1009. PMID: 22748404, DOI: 10.1016/j.amjmed.2011.11.016.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overCohort StudiesFemaleGuideline AdherenceHealthcare DisparitiesHospital MortalityHumansMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionOutcome and Process Assessment, Health CarePractice Guidelines as TopicPrognosisQuality Indicators, Health CareRegistriesRisk FactorsSex FactorsUnited StatesConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionQuality of careYounger patientsMyocardial infarctionHospital outcomesOlder patientsST-segment elevation myocardial infarction casesGuidelines-Coronary Artery Disease registryTraditional cardiovascular risk factorsCoronary Artery Disease registryCardiovascular risk factorsAmerican Heart AssociationMyocardial infarction casesOlder counterpartsYounger cohortsTime trend analysisHospital mortalityHospital deathHeart AssociationRisk factorsWorse outcomesInfarction casesThrombolytic timeDisease RegistryCare and Outcomes of Asian-American Acute Myocardial Infarction Patients
Qian F, Ling F, Deedwania P, Hernandez A, Fonarow G, Cannon C, Peterson E, Peacock W, Kaltenbach L, Laskey W, Schwamm L, Bhatt D. Care and Outcomes of Asian-American Acute Myocardial Infarction Patients. Circulation Cardiovascular Quality And Outcomes 2012, 5: 126-133. PMID: 22235068, DOI: 10.1161/circoutcomes.111.961987.Peer-Reviewed Original ResearchConceptsGuidelines-Coronary Artery Disease programAcute myocardial infarctionAMI patientsDisease programsBalloon timeWhite patientsAcute myocardial infarction patientsAMI performance measuresDefect-free careHospital mortality rateEvidence-based careAmerican Heart AssociationMyocardial infarction patientsAsian American patientsUnited States CentersHospital mortalityCessation counselingUnadjusted mortalityHeart failureHeart AssociationInfarction patientsMyocardial infarctionHigh prevalenceClinical careMortality rate
2011
Regional differences in clinical profile, quality of care, and outcomes among Hispanic patients hospitalized with acute myocardial infarction in the Get with Guidelines–Coronary Artery Disease (GWTG-CAD) Registry
Krim S, Vivo R, Krim N, Cox M, Hernandez A, Peterson E, Fonarow G, Piña I, Schwamm L, Bhatt D. Regional differences in clinical profile, quality of care, and outcomes among Hispanic patients hospitalized with acute myocardial infarction in the Get with Guidelines–Coronary Artery Disease (GWTG-CAD) Registry. American Heart Journal 2011, 162: 988-995.e4. PMID: 22137071, DOI: 10.1016/j.ahj.2011.09.006.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionHispanic patientsQuality of careHospital mortalityClinical profileEnzyme inhibitors/angiotensin receptor blockersGuidelines-Coronary Artery Disease registryGuideline-recommended therapiesAngiotensin receptor blockersLipid-lowering therapyLonger hospital stayHigh rateHospital outcomesHospital stayReceptor blockersClinical characteristicsMale predominanceThrombolysis timeΒ-blockersRegional differencesDisease RegistryPatientsInfarctionHispanicsComparison of Composite Measure Methodologies for Rewarding Quality of Care
Eapen Z, Fonarow G, Dai D, O'Brien S, Schwamm L, Cannon C, Heidenreich P, Bhatt D, Peterson E, Hernandez A. Comparison of Composite Measure Methodologies for Rewarding Quality of Care. Circulation Cardiovascular Quality And Outcomes 2011, 4: 610-618. PMID: 22010200, DOI: 10.1161/circoutcomes.111.961391.Peer-Reviewed Original ResearchConceptsReadmission ratesHospital rankingsRisk-standardized readmission ratesRisk-standardized mortality ratesOpportunity-based scoreAcute myocardial infarctionBottom quintileComposite scoreModest correlationQuality Improvement ProgramComposite measureCause mortalityNumber of hospitalsHealth care performanceMyocardial infarctionMortality rateHospitalCare performanceScoresSimilar changesMortalityQuintileObservational analysisComposite performance measureQUALITY OF CARE AND OUTCOMES AMONG PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND CHRONIC RENAL INSUFFICIENCY: REPORT FROM THE GET WITH THE GUIDELINES PROGRAM
Vasaiwala S, Cannon C, Fonarow G, Peacock F, Laskey W, Schwamm L, Liang L, Hernandez A, Peterson E, Bhatt D. QUALITY OF CARE AND OUTCOMES AMONG PATIENTS WITH ACUTE MYOCARDIAL INFARCTION AND CHRONIC RENAL INSUFFICIENCY: REPORT FROM THE GET WITH THE GUIDELINES PROGRAM. Journal Of The American College Of Cardiology 2011, 57: e1029. DOI: 10.1016/s0735-1097(11)61029-2.Peer-Reviewed Original ResearchREGIONAL DIFFERENCES IN CLINICAL PROFILE, QUALITY OF CARE AND OUTCOMES AMONG HISPANIC PATIENTS HOSPITALIZED WITH ACUTE MYOCARDIAL INFARCTION IN THE GET WITH GUIDELINES-CORONARY ARTERY DISEASE REGISTRY
Krim S, Vivo R, Krim N, Cox M, Hernandez A, Peterson E, Fonarow G, Piña I, Schwamm L, Bhatt D. REGIONAL DIFFERENCES IN CLINICAL PROFILE, QUALITY OF CARE AND OUTCOMES AMONG HISPANIC PATIENTS HOSPITALIZED WITH ACUTE MYOCARDIAL INFARCTION IN THE GET WITH GUIDELINES-CORONARY ARTERY DISEASE REGISTRY. Journal Of The American College Of Cardiology 2011, 57: e1162. DOI: 10.1016/s0735-1097(11)61162-5.Peer-Reviewed Original ResearchQUALITY OF CARE AND OUTCOMES IN 5,339 PATIENTS AGED 80 OR ABOVE PRESENTING WITH ST-ELEVATION MYOCARDIAL INFARCTION: ANALYSIS FROM AMERICAN HEART ASSOCIATION GET WITH THE GUIDELINES: CORONARY ARTERY DISEASE
Medina H, Cannon C, Fonarow G, Peacock F, Laskey W, Grau-Sepulveda M, Fernandez A, Peterson E, Schwamm L, Bhatt D. QUALITY OF CARE AND OUTCOMES IN 5,339 PATIENTS AGED 80 OR ABOVE PRESENTING WITH ST-ELEVATION MYOCARDIAL INFARCTION: ANALYSIS FROM AMERICAN HEART ASSOCIATION GET WITH THE GUIDELINES: CORONARY ARTERY DISEASE. Journal Of The American College Of Cardiology 2011, 57: e1285. DOI: 10.1016/s0735-1097(11)61285-0.Peer-Reviewed Original Research
2009
Hospital performance recognition with the Get With The Guidelines Program and mortality for acute myocardial infarction and heart failure
Heidenreich P, Lewis W, LaBresh K, Schwamm L, Fonarow G. Hospital performance recognition with the Get With The Guidelines Program and mortality for acute myocardial infarction and heart failure. American Heart Journal 2009, 158: 546-553. PMID: 19781413, DOI: 10.1016/j.ahj.2009.07.031.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHeart failureMyocardial infarctionProcess of careAdditional adjustmentGuideline programHeart failure mortalityRisk-adjusted mortalityAmerican Heart AssociationAcute myocardial infractionMI mortalityHeart AssociationHospital characteristicsMyocardial infractionLower riskHospitalMortalityMedicaid ServicesCareHigh levelsInfarctionCardiac processesMedicareFailureGWTG