2005
The Evolving Role of Acute Stroke Imaging in Intravenous Thrombolytic Therapy: Patient Selection and Outcomes Assessment
Sims J, Schwamm L. The Evolving Role of Acute Stroke Imaging in Intravenous Thrombolytic Therapy: Patient Selection and Outcomes Assessment. Neuroimaging Clinics Of North America 2005, 15: 421-440. PMID: 16198950, DOI: 10.1016/j.nic.2005.06.001.Peer-Reviewed Original ResearchConceptsPatient selectionIntravenous thrombolytic therapyStroke pathophysiologyThrombolytic trialsPenumbral tissueAcute strokeLarge infarctionCerebral ischemiaRisk stratificationThrombolytic therapyCT perfusionStroke mechanismBrain hemorrhageTherapeutic successCT angiographyUnenhanced CTOutcome assessmentPotential future roleEarly signsEarly trialsMR imagingThrombolysisInfarctionTrialsEvolving role
2004
Characterization and evolution of diffusion MR imaging abnormalities in stroke patients undergoing intra-arterial thrombolysis.
Schaefer P, Hassankhani A, Putman C, Sorensen A, Schwamm L, Koroshetz W, Gonzalez R. Characterization and evolution of diffusion MR imaging abnormalities in stroke patients undergoing intra-arterial thrombolysis. American Journal Of Neuroradiology 2004, 25: 951-7. PMID: 15205129, PMCID: PMC7975652.Peer-Reviewed Original ResearchConceptsIntra-arterial thrombolysisDiffusion-weighted imagingDWI findingsDWI ratioADC ratioReperfusion therapyAcute strokeApparent diffusion coefficientInitial diffusion-weighted imagingPretreatment diffusion-weighted imagingADC valuesRespective mean changesEventual infarctionAcute occlusionAnterior circulationStroke patientsLesion volumeMean changePatientsThrombolysisLesion growthMR imagingTissue viabilityLesionsInfarction
1999
Hyperacute Stroke: Simultaneous Measurement of Relative Cerebral Blood Volume, Relative Cerebral Blood Flow, and Mean Tissue Transit Time
Sorensen A, Copen W, Ostergaard L, Buonanno F, Gonzalez R, Rordorf G, Rosen B, Schwamm L, Weisskoff R, Koroshetz W. Hyperacute Stroke: Simultaneous Measurement of Relative Cerebral Blood Volume, Relative Cerebral Blood Flow, and Mean Tissue Transit Time. Radiology 1999, 210: 519-27. PMID: 10207439, DOI: 10.1148/radiology.210.2.r99fe06519.Peer-Reviewed Original ResearchConceptsRelative cerebral blood flowCerebral blood flowRelative cerebral blood volumeCerebral blood volumeBlood flowBlood volumeTissue transit timeLesion volumeMR imagingDiffusion findingsAcute lesion volumesCompensatory hemodynamic responseHemodynamic MR imagingCerebral ischemic strokeOnset of symptomsInitial blood flowAltered blood flowBlood volume mapsFunctional magnetic resonance imagingMagnetic resonance imagingTransit time mapsBlood flow mapsInitial blood volumeInfarct volumeHemodynamic abnormalitiesDiffusion-weighted MR Imaging: Diagnostic Accuracy in Patients Imaged within 6 Hours of Stroke Symptom Onset
González R, Schaefer P, Buonanno F, Schwamm L, Budzik R, Rordorf G, Wang B, Sorensen A, Koroshetz W. Diffusion-weighted MR Imaging: Diagnostic Accuracy in Patients Imaged within 6 Hours of Stroke Symptom Onset. Radiology 1999, 210: 155-62. PMID: 9885601, DOI: 10.1148/radiology.210.1.r99ja02155.Peer-Reviewed Original ResearchConceptsFinal clinical diagnosisDiffusion-weighted imagesDiffusion-weighted MR imagingDiffusion-weighted imagingConventional MR imagingMR imagingSymptom onsetBlinded reviewClinical diagnosisDiagnostic accuracyStroke symptom onsetDiffusion-weighted magnetic resonance imagingMagnetic resonance imagingT2-weighted MR imagingAcute strokeStroke symptomsFinal diagnosisTomographic scanStrokelike symptomsPatientsPatient recordsResonance imagingStrokeDiagnosisCT
1996
Hyperacute stroke: evaluation with combined multisection diffusion-weighted and hemodynamically weighted echo-planar MR imaging.
Sorensen A, Buonanno F, Gonzalez R, Schwamm L, Lev M, Huang-Hellinger F, Reese T, Weisskoff R, Davis T, Suwanwela N, Can U, Moreira J, Copen W, Look R, Finklestein S, Rosen B, Koroshetz W. Hyperacute stroke: evaluation with combined multisection diffusion-weighted and hemodynamically weighted echo-planar MR imaging. Radiology 1996, 199: 391-401. PMID: 8668784, DOI: 10.1148/radiology.199.2.8668784.Peer-Reviewed Original ResearchConceptsInfarct volumeNormal findingsHyperacute cerebral ischemiaMagnetic resonance imagingEcho-planar MR imagingAcute hemiparesisAcute strokeCerebral ischemiaInitial CTMR imaging techniquesStroke diagnosisPatientsResonance imagingSubsequent imagingMR imagingAbnormalitiesConventional MRCTImaging techniquesImagingMRHoursFindingsHemiparesisInfarction