2022
Functional status at 30 and 90 days after mild ischaemic stroke
Gardener H, Romano L, Smith E, Campo-Bustillo I, Khan Y, Tai S, Riley N, Sacco R, Khatri P, Alger H, Mac Grory B, Gulati D, Sangha N, Olds K, Benesch C, Kelly A, Brehaut S, Kansara A, Schwamm L, Romano J. Functional status at 30 and 90 days after mild ischaemic stroke. Stroke And Vascular Neurology 2022, 7: 375-380. PMID: 35474180, PMCID: PMC9614160, DOI: 10.1136/svn-2021-001333.Peer-Reviewed Original ResearchModified Rankin ScaleMild ischemic strokeIschemic strokeMRS 0Stroke severityStudy populationDisability statusGreater stroke severityIschemic stroke participantsAlteplase treatmentClinical characteristicsHealth StrokeHospital arrivalRankin ScaleStroke StudyMild strokeFunctional statusMedical recordsFunctional improvementStroke participantsMultivariable modelFunctional declineLong-term recoveryIdentifies predictorsStudy participants
2021
Exploring the Unmet Need in Acute Ischemic Stroke Patients Not Treated With Intravenous Alteplase: The Get With The Guidelines‐Stroke Registry
Mac Grory B, Xian Y, Solomon N, Matsouaka R, Decker‐Palmer M, Fonarow G, Smith E, Schwamm L. Exploring the Unmet Need in Acute Ischemic Stroke Patients Not Treated With Intravenous Alteplase: The Get With The Guidelines‐Stroke Registry. Stroke Vascular And Interventional Neurology 2021, 2 DOI: 10.1161/svin.121.000226.Peer-Reviewed Original ResearchGuidelines-Stroke registryAcute ischemic strokeIschemic strokePatient populationCommon reasonUnmet needAcute ischemic stroke patientsIntravenous tissue plasminogen activatorAcute ischemic stroke careGuidelines-Stroke hospitalsIschemic stroke patientsIschemic stroke careLong-term outcomesTissue plasminogen activatorAlteplase deliveryHospital mortalityIntravenous alteplaseClinical characteristicsConclusions PatientsReadmission ratesEarly administrationPostdischarge costsStroke careStroke patientsFunctional outcomeClinical Characteristics, Management, and In-Hospital Outcomes in Patients With Stroke or Transient Ischemic Attack in China
Gu H, Yang X, Wang C, Zhao X, Wang Y, Liu L, Meng X, Jiang Y, Li H, Liu C, Wangqin R, Fonarow G, Schwamm L, Xian Y, Li Z, Wang Y. Clinical Characteristics, Management, and In-Hospital Outcomes in Patients With Stroke or Transient Ischemic Attack in China. JAMA Network Open 2021, 4: e2120745. PMID: 34387677, PMCID: PMC8363916, DOI: 10.1001/jamanetworkopen.2021.20745.Peer-Reviewed Original ResearchConceptsTransient ischemic attackChinese Stroke Center AllianceMajor adverse cardiovascular eventsHospital clinical outcomesQuality improvement studyIschemic strokeIntracerebral hemorrhageIschemic attackClinical characteristicsClinical outcomesPoor outcomeIntravenous recombinant tissue plasminogen activatorTemporal improvementRecombinant tissue plasminogen activatorAdverse cardiovascular eventsIn-Hospital OutcomesUse of anticoagulantsComposite scoreImprovement studyTissue plasminogen activatorMean composite scoreHealth care systemHospital complicationsTIA admissionsTIA careReperfusion Treatment and Stroke Outcomes in Hospitals With Telestroke Capacity
Wilcock A, Schwamm L, Zubizarreta J, Zachrison K, Uscher-Pines L, Richard J, Mehrotra A. Reperfusion Treatment and Stroke Outcomes in Hospitals With Telestroke Capacity. JAMA Neurology 2021, 78: 527-535. PMID: 33646272, PMCID: PMC7922240, DOI: 10.1001/jamaneurol.2021.0023.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeReperfusion treatmentIschemic strokeShort-term acute carePatients 85 yearsLow-volume hospitalsYear of admissionHospital emergency departmentTraditional Medicare beneficiariesClinical characteristicsCritical access hospitalsStroke outcomeAcute careControl hospitalsEmergency departmentMean ageFunctional statusPrimary diagnosisStroke expertiseHospital characteristicsMAIN OUTCOMEMedicare beneficiariesPatientsHospitalCare patternsClinical Characteristics and Outcomes Associated With Oral Anticoagulant Use Among Patients Hospitalized With Intracerebral Hemorrhage
Xian Y, Zhang S, Inohara T, Grau-Sepulveda M, Matsouaka RA, Peterson ED, Piccini JP, Smith EE, Sheth KN, Bhatt DL, Fonarow GC, Schwamm LH. Clinical Characteristics and Outcomes Associated With Oral Anticoagulant Use Among Patients Hospitalized With Intracerebral Hemorrhage. JAMA Network Open 2021, 4: e2037438. PMID: 33591368, PMCID: PMC7887660, DOI: 10.1001/jamanetworkopen.2020.37438.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnticoagulantsCase-Control StudiesCerebral HemorrhageCohort StudiesDependent AmbulationDrug Therapy, CombinationDual Anti-Platelet TherapyFactor Xa InhibitorsFemaleFunctional StatusHospicesHospital MortalityHumansMaleMiddle AgedOdds RatioPatient DischargePlatelet Aggregation InhibitorsRegistriesRisk FactorsWarfarinConceptsOral anticoagulant useOral anticoagulantsFXa inhibitorsHospital mortalityAnticoagulant useCohort studyIndependent ambulationMRS scoreIntracerebral hemorrhageGuidelines-Stroke registryCardiovascular risk factorsHospital mortality riskFactor Xa inhibitorsConcomitant warfarinOral anticoagulationAnticoagulation therapyAntiplatelet therapyHospital outcomesClinical characteristicsRankin ScaleSecondary outcomesPrimary outcomeRisk factorsWorse outcomesHigh prevalence
2020
Left Atrial Mechanics Assessed Early during Hospitalization for Cryptogenic Stroke Are Associated with Occult Atrial Fibrillation: A Speckle-Tracking Strain Echocardiography Study
Deferm S, Bertrand PB, Churchill TW, Sharma R, Vandervoort PM, Schwamm LH, Yoerger Sanborn DM. Left Atrial Mechanics Assessed Early during Hospitalization for Cryptogenic Stroke Are Associated with Occult Atrial Fibrillation: A Speckle-Tracking Strain Echocardiography Study. Journal Of The American Society Of Echocardiography 2020, 34: 156-165. PMID: 33132019, DOI: 10.1016/j.echo.2020.09.009.Peer-Reviewed Original ResearchConceptsMobile cardiac outpatient telemetryOccult atrial fibrillationBooster pump functionAtrial fibrillationCryptogenic strokeAtrial mechanicsStrain echocardiographyReservoir strainPump functionBaseline cardiovascular risk profileLA booster pump functionPresence of AFCardiovascular risk profileLA volume indexReceiver operator curve analysisOperator curve analysisSpontaneous cardioversionEmbolic strokeClinical characteristicsRetrospective cohortEchocardiography studyLA sizeMedian timeStroke hospitalizationsEchocardiography
2018
International Comparison of Patient Characteristics and Quality of Care for Ischemic Stroke: Analysis of the China National Stroke Registry and the American Heart Association Get With The Guidelines––Stroke Program
Wangqin R, Laskowitz D, Wang Y, Li Z, Wang Y, Liu L, Liang L, Matsouaka R, Saver J, Fonarow G, Bhatt D, Smith E, Schwamm L, Bettger J, Hernandez A, Peterson E, Xian Y. International Comparison of Patient Characteristics and Quality of Care for Ischemic Stroke: Analysis of the China National Stroke Registry and the American Heart Association Get With The Guidelines––Stroke Program. Journal Of The American Heart Association 2018, 7: e010623. PMID: 30371291, PMCID: PMC6474951, DOI: 10.1161/jaha.118.010623.Peer-Reviewed Original ResearchConceptsChina National Stroke RegistryNational Stroke RegistryAcute ischemic strokeStroke RegistryIschemic strokeChinese patientsDeep venous thrombosis prophylaxisHealth Stroke ScaleVenous thrombosis prophylaxisAcute stroke careAdministration of thrombolyticsEvidence-based guidelinesAmerican Heart AssociationQuality of careBackground AdherenceDischarge antithromboticsThrombosis prophylaxisCessation counselingStroke ProgramStroke ScaleClinical characteristicsHospital arrivalNeedle timePatient characteristicsSecondary prevention
2017
Unexplained Variation for Hospitals’ Use of Inpatient Rehabilitation and Skilled Nursing Facilities After an Acute Ischemic Stroke
Xian Y, Thomas L, Liang L, Federspiel J, Webb L, Bushnell C, Duncan P, Schwamm L, Stein J, Fonarow G, Hoenig H, Montalvo C, George M, Lutz B, Peterson E, Bettger J. Unexplained Variation for Hospitals’ Use of Inpatient Rehabilitation and Skilled Nursing Facilities After an Acute Ischemic Stroke. Stroke 2017, 48: 2836-2842. PMID: 28830975, DOI: 10.1161/strokeaha.117.016904.Peer-Reviewed Original ResearchConceptsInpatient rehabilitation facilitySkilled nursing facilitiesAcute ischemic strokeHospital-level variationIschemic strokeNursing facilitiesGuidelines-Stroke hospitalsMultilevel logistic regression modelsMedian odds ratioGeographic availabilityLogistic regression modelsIRF patientsHospital complicationsSNF patientsClinical characteristicsComorbid conditionsInpatient rehabilitationHospital characteristicsClinical registryOdds ratioRehabilitation facilityHospital useMedicare beneficiariesPatientsHospital
2014
Hospitalized Hemorrhagic Stroke Patients with Renal Insufficiency: Clinical Characteristics, Care Patterns, and Outcomes
Ovbiagele B, Schwamm L, Smith E, Grau-Sepulveda M, Saver J, Bhatt D, Hernandez A, Peterson E, Fonarow G. Hospitalized Hemorrhagic Stroke Patients with Renal Insufficiency: Clinical Characteristics, Care Patterns, and Outcomes. Journal Of Stroke And Cerebrovascular Diseases 2014, 23: 2265-2273. PMID: 25158677, DOI: 10.1016/j.jstrokecerebrovasdis.2014.04.016.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseNormal renal functionICH patientsClinical characteristicsRenal functionKidney diseaseCare patternsDeep venous thrombosis prophylaxisGuidelines-Stroke programGWTG-Stroke programVenous thrombosis prophylaxisThird of patientsGlomerular filtration rateHemorrhagic stroke patientsNormal kidney functionIntracerebral hemorrhage patientsSmoking cessation interventionHospital mortalityThrombosis prophylaxisHospital outcomesRenal dysfunctionRenal insufficiencyInpatient mortalityClinical outcomesComorbid conditionsUse of a Standardized Assessment to Predict Rehabilitation Care After Acute Stroke
Stein J, Bettger J, Sicklick A, Hedeman R, Magdon-Ismail Z, Schwamm L. Use of a Standardized Assessment to Predict Rehabilitation Care After Acute Stroke. Archives Of Physical Medicine And Rehabilitation 2014, 96: 210-217. PMID: 25102387, DOI: 10.1016/j.apmr.2014.07.403.Peer-Reviewed Original ResearchConceptsInpatient rehabilitation facilitySkilled nursing facilitiesInstitution-based rehabilitationPredictors of referralDischarge homeBarthel IndexBI scoreRehabilitation needsSociodemographic characteristicsShort Portable Mental Status QuestionnaireDischarge disposition locationGuidelines-Stroke registryHealth Stroke ScalePatients' sociodemographic characteristicsDaily living impairmentStandardized assessmentHigher BI scoreMental Status QuestionnaireProspective pilot projectPrestroke disabilityStroke ScaleAcute strokeClinical characteristicsOlder patientsRankin Scale
2011
Regional differences in clinical profile, quality of care, and outcomes among Hispanic patients hospitalized with acute myocardial infarction in the Get with Guidelines–Coronary Artery Disease (GWTG-CAD) Registry
Krim S, Vivo R, Krim N, Cox M, Hernandez A, Peterson E, Fonarow G, Piña I, Schwamm L, Bhatt D. Regional differences in clinical profile, quality of care, and outcomes among Hispanic patients hospitalized with acute myocardial infarction in the Get with Guidelines–Coronary Artery Disease (GWTG-CAD) Registry. American Heart Journal 2011, 162: 988-995.e4. PMID: 22137071, DOI: 10.1016/j.ahj.2011.09.006.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionHispanic patientsQuality of careHospital mortalityClinical profileEnzyme inhibitors/angiotensin receptor blockersGuidelines-Coronary Artery Disease registryGuideline-recommended therapiesAngiotensin receptor blockersLipid-lowering therapyLonger hospital stayHigh rateHospital outcomesHospital stayReceptor blockersClinical characteristicsMale predominanceThrombolysis timeΒ-blockersRegional differencesDisease RegistryPatientsInfarctionHispanics
2010
Age-Related Differences in Characteristics, Performance Measures, Treatment Trends, and Outcomes in Patients With Ischemic Stroke
Fonarow G, Reeves M, Zhao X, Olson D, Smith E, Saver J, Schwamm L. Age-Related Differences in Characteristics, Performance Measures, Treatment Trends, and Outcomes in Patients With Ischemic Stroke. Circulation 2010, 121: 879-891. PMID: 20142445, DOI: 10.1161/circulationaha.109.892497.Peer-Reviewed Original ResearchConceptsIschemic stroke patientsOlder patientsIschemic strokeAge-related differencesAge groupsClinical characteristicsStroke patientsTreatment gapGuideline-recommended therapiesGuidelines-Stroke programWorse poststroke outcomesEarly clinical outcomesAcute ischemic strokeLarge contemporary cohortIschemic stroke admissionsHospital mortalityHospital outcomesStroke admissionsYounger patientsClinical outcomesContemporary cohortRecent smokersAtrial fibrillationMean agePoststroke outcomes
2002
‘Footprints’ of Transient Ischemic Attacks: A Diffusion-Weighted MRI Study
Ay H, Oliveira-Filho J, Buonanno F, Schaefer P, Furie K, Chang Y, Rordorf G, Schwamm L, Gonzalez R, Koroshetz W. ‘Footprints’ of Transient Ischemic Attacks: A Diffusion-Weighted MRI Study. Cerebrovascular Diseases 2002, 14: 177-186. PMID: 12403950, DOI: 10.1159/000065682.Peer-Reviewed Original ResearchConceptsTransient ischemic attackFast fluid attenuated inversion recoveryDiffusion-weighted imagingIschemic attackDWI lesionsFocal neurologic symptomsHalf of patientsDiffusion-weighted MRI studiesFluid attenuated inversion recoveryAttenuated inversion recoveryBrain infarctionClinical characteristicsNeurologic symptomsConsecutive patientsIndependent predictorsIschemic injuryMotor symptomsRecent infarctionCerebrovascular abnormalitiesClinical syndromeVascular territoriesStroke mechanismMRI studiesPatientsInfarction
1999
Diffusion-Weighted Imaging Identifies a Subset of Lacunar Infarction Associated With Embolic Source
Ay H, Oliveira-Filho J, Buonanno F, Ezzeddine M, Schaefer P, Rordorf G, Schwamm L, Gonzalez R, Koroshetz W. Diffusion-Weighted Imaging Identifies a Subset of Lacunar Infarction Associated With Embolic Source. Stroke 1999, 30: 2644-2650. PMID: 10582991, DOI: 10.1161/01.str.30.12.2644.Peer-Reviewed Original ResearchConceptsLacunar syndromeSmall infarctsIdentifiable causeClinical syndromeCareful pathological studyClassic lacunar syndromeDWI hyperintense lesionsSingle lacunar infarctionBrain stem lesionsDay of admissionDistinct clinical syndromeDiffusion-weighted imagingMultiple infarctionsEmbolic mechanismEmbolic sourceArtery territoryClinical characteristicsLacunar infarctionSecondary preventionConsecutive patientsAcute lesionsIndex lesionSuch infarctsEmergency roomPathological studies