Sex Differences in Tryptophan Metabolism via the Kynurenine Pathway in Acute Ischemic Stroke
Dylla L, Higgins H, Poisson S, Vu T, Reisz J, Herson P, Monte A. Sex Differences in Tryptophan Metabolism via the Kynurenine Pathway in Acute Ischemic Stroke. Clinical Therapeutics 2024 PMID: 39603869, DOI: 10.1016/j.clinthera.2024.10.015.Peer-Reviewed Original ResearchAcute ischemic strokeQuinolinic acid levelsLevels of tryptophanNIHSS scoreTryptophan metabolismMetabolite levelsKynurenine pathwayLinear regression modelsIncreased lifetime risk of strokeLifetime risk of strokeMass spectrometry-based metabolomicsPotential sex differencesDownstream kynurenine metabolitesAssociated with poor outcomesIschemic strokeKynurenine pathway metabolitesDecreased tryptophan concentrationsIncreased lifetime riskRegression modelsMultivariate linear regression modelSex differencesExperience worse outcomesRisk of strokeAcid levelsKynurenine metabolitesAbstract 106: Circulating Interleukin-6 Levels Early During Active Stroke Estimate Time of Stroke Onset: Potential New Clinical Biomarker Tool From a Mobile Stroke Unit
Kowalski R, Ledreux A, Violette J, Neumann R, Grotta J, Ornelas D, Thompson J, Monte A, Dylla L, Coughlan C, Yu X, Graner M, Jones W. Abstract 106: Circulating Interleukin-6 Levels Early During Active Stroke Estimate Time of Stroke Onset: Potential New Clinical Biomarker Tool From a Mobile Stroke Unit. Stroke 2024, 55: a106-a106. DOI: 10.1161/str.55.suppl_1.106.Peer-Reviewed Original ResearchInterleukin-6 levelsMobile stroke unitInterleukin-6Symptom onsetLesion volumeAcute strokeHealthy controlsMobile stroke unit patientsDevelopment of immunomodulatory therapiesMedian interleukin-6Circulating interleukin-6 levelsMeasurement of interleukin-6Associated with lesion volumeMedian initial NIHSS scoreDWI lesion volumeCirculating interleukin-6Plasma interleukin-6Stroke patientsOnset timeIL-6 responseTime of stroke onsetImmunomodulatory therapyMedian ageThrombolysis windowNIHSS score